Looking at Marine-Derived Bioactive Molecules as Upcoming Anti-Diabetic Agents: A Special Emphasis on PTP1B Inhibitors
| العنوان: | Looking at Marine-Derived Bioactive Molecules as Upcoming Anti-Diabetic Agents: A Special Emphasis on PTP1B Inhibitors |
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| المؤلفون: | Mehdi Sharifi-Rad, Natália Martins, Solomon Habtemariam, Javad Sharifi-Rad, Bahare Salehi, Shahira M. Ezzat, Mahitab H. El Bishbishy |
| المساهمون: | Instituto de Investigação e Inovação em Saúde |
| المصدر: | Molecules, Vol 23, Iss 12, p 3334 (2018) Molecules Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Drug, Enzyme Inhibitors / isolation & purification, type 2 diabetes mellitus, media_common.quotation_subject, Phosphatase, Pharmaceutical Science, Enzyme Inhibitors / chemistry, Review, Biology, Pharmacology, 01 natural sciences, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Insulin resistance, lcsh:Organic chemistry, Diabetes mellitus, Drug Discovery, medicine, Hypoglycemic Agents, Animals, Humans, Physical and Theoretical Chemistry, Enzyme Inhibitors, protein-tyrosine phosphatase 1B, Ecosystem, Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism, media_common, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors, 010405 organic chemistry, Organic Chemistry, marine metabolites, Type 2 Diabetes Mellitus, Enzyme Inhibitors / pharmacology, Marine invertebrates, medicine.disease, Obesity, 0104 chemical sciences, Hypoglycemic Agents / pharmacology, Insulin receptor, insulin signaling pathways, 030104 developmental biology, Chemistry (miscellaneous), biology.protein, Molecular Medicine |
| الوصف: | Diabetes mellitus (DM) is a chronic metabolic disease with high morbimortality rates. DM has two types: type 1, which is often associated with a total destruction of pancreatic beta cells, and non-insulin-dependent or type 2 diabetes mellitus (T2DM), more closely associated with obesity and old age. The main causes of T2DM are insulin resistance and/or inadequate insulin secretion. Protein-tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling pathways and plays an important role in T2DM, as its overexpression may induce insulin resistance. Thus, since PTP1B may be a therapeutic target for both T2DM and obesity, the search for novel and promising natural inhibitors has gained much attention. Hence, several marine organisms, including macro and microalgae, sponges, marine invertebrates, sea urchins, seaweeds, soft corals, lichens, and sea grasses, have been recently evaluated as potential drug sources. This review provides an overview of the role of PTP1B in T2DM insulin signaling and treatment, and highlights the recent findings of several compounds and extracts derived from marine organisms and their relevance as upcoming PTP1B inhibitors. In this systematic literature review, more than 60 marine-derived metabolites exhibiting PTP1B inhibitory activity are listed. Their chemical classes, structural features, relative PTP1B inhibitory potency (assessed by IC 50 values), and structure–activity relationships (SARs) that could be drawn from the available data are discussed. The upcoming challenge in the field of marine research—metabolomics—is also addressed. N. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT–Portugal) for the Strategic project, reference numbers UID/BIM/04293/2013 and “NORTE2020-Programa Operacional Regional do Norte” (NORTE-01-0145-FEDER-000012). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b7f845bb381f60feaef9ae0d537188Test https://www.mdpi.com/1420-3049/23/12/3334Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....78b7f845bb381f60feaef9ae0d537188 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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