التفاصيل البيبلوغرافية
| العنوان: |
Laminarin From Salicornia herbacea Stimulates Glucose Uptake Through AMPK-p38 MAPK Pathways in L6 Muscle Cells |
| المؤلفون: |
Kim, Ji H., Lee, Jung O., Moon, Ji W., Kang, Min J., Byun, Won S., Han, Jeong A., Kim, Su J., Park, Sun H., Kim, Hyeon S. |
| المصدر: |
Natural Product Communications ; volume 15, issue 3, page 1934578X2090140 ; ISSN 1934-578X 1555-9475 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| الوصف: |
Laminarin is a component of brown seaweed, especially isolated from Salicornia herbacea. Laminarin was known to have various physiological functions, however, the molecular mechanism is still unclear. In this study, we report that laminarin stimulates an activation of AMP-activated protein kinase (AMPK) and increases glucose uptake in rat L6 myotubes. Laminarin also increases an intracellular calcium release. Inhibition of Ca 2+ release, using with CaMKK inhibitor, STO-609, blocked laminarin-induced AMPK activity, indicating that laminarin stimulated AMPK activity via calcium. In addition, laminarin activates p38 mitogen-activated protein kinase (MAPK) signaling pathways depending on AMPK activity. Moreover, the inhibition of either AMPK or p38 MAPK blocked laminarin-induced glucose uptake in rat L6 myotubes. Taken together, these results demonstrate that the hypoglycemic effect of laminarin is caused by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/1934578x20901409 |
| DOI: |
10.1177/1934578X20901409 |
| الإتاحة: |
https://doi.org/10.1177/1934578x20901409Test |
| حقوق: |
https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.CC14EB31 |
| قاعدة البيانات: |
BASE |
