المؤلفون: Geoffrey D. Hannigan, Ondrej Klempir, David Prihoda, Daria J. Hazuda, Danny A. Bitton, Julia M. Maritz, Christopher H. Woelk, David Dzamba

المصدر: Natural Product Reports. 38:1100-1108

مصطلحات موضوعية: 0301 basic medicine, Genomics, Biology, Machine learning, computer.software_genre, Biochemistry, Field (computer science), Machine Learning, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Humans, Natural (music), Chemistry (relationship), Biological Products, business.industry, Chemistry, Drug discovery, Microbiota, Organic Chemistry, Biosynthetic Pathways, Variety (cybernetics), 030104 developmental biology, Pattern recognition (psychology), Identification (biology), Artificial intelligence, business, computer, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cf659e80580bf5bcf9853e37fa4e9cTest
https://doi.org/10.1039/d0np00055hTest

المؤلفون: Xue Liang, Begüm D. Topçuoğlu, Erin Spofford, Julia M. Maritz, Sushma Kommineni, Cory H. White, Olga Danilchanka, Daria J. Hazuda, Geoffrey D. Hannigan, Teresa M. Weber, Michael P. Citron, Jianying Xiao, Christopher H. Woelk, Daniel C. Freed, Erin Bryant-Hall, Keun-Joong Lee, Jane Fontenot, Gokul Swaminathan, Gino Salituro, Dario A. Gutierrez, Mahika Kadam, James E. Norton, Abigail L. Reens

المصدر: Vaccines
Volume 9
Issue 11
Vaccines, Vol 9, Iss 1340, p 1340 (2021)

مصطلحات موضوعية: medicine.drug_class, Immunology, Antibiotics, microbiome, Spleen, Biology, Article, Immune system, Immunity, Drug Discovery, medicine, Pharmacology (medical), Microbiome, Pharmacology, Lachnospiraceae, vaccines, Vaccine efficacy, immunity, Vaccination, Infectious Diseases, medicine.anatomical_structure, Medicine, Vancomycin, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0cf1d7a92a3cd65deaed86a86d25feTest

المؤلفون: Patricia Akrivoulis, Sushma Kommineni, Gokul Swaminathan, Dario A. Gutierrez, Daria J. Hazuda, James E. Norton

المصدر: Vaccines
Volume 9
Issue 3
Vaccines, Vol 9, Iss 225, p 225 (2021)

مصطلحات موضوعية: 0301 basic medicine, Chemokine, medicine.medical_treatment, Immunology, lcsh:Medicine, microbiome, Biology, Article, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cancer immunotherapy, Drug Discovery, medicine, Pharmacology (medical), Microbiome, dendritic cells, innate immunity, host–microbiome interactions, commensal bacteria, Pharmacology, Innate immune system, immune modulation, Host (biology), commensal bacteria, dendritic cells, innate immunity, lcsh:R, host–microbiome interactions, 030104 developmental biology, Infectious Diseases, 030220 oncology & carcinogenesis, biology.protein, Ex vivo, CD80

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe08d849722f056bf912b163df92d59Test

المؤلفون: Ming-Tain Lai, Carey Hwang, Daria J. Hazuda

المصدر: ACS infectious diseases. 6(1)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Nevirapine, Efavirenz, Anti-HIV Agents, Pyridones, 030106 microbiology, HIV Infections, Translational Research, Biomedical, 03 medical and health sciences, chemistry.chemical_compound, Doravirine, Drug Resistance, Viral, medicine, Humans, Drug Interactions, Intensive care medicine, Clinical Trials as Topic, Reverse-transcriptase inhibitor, Drug discovery, business.industry, virus diseases, Triazoles, Clinical trial, 030104 developmental biology, Infectious Diseases, chemistry, Tolerability, Rilpivirine, Drug Design, HIV-1, Reverse Transcriptase Inhibitors, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb59893542ce2923f2ce16474f5b61Test
https://pubmed.ncbi.nlm.nih.gov/31621289Test

المؤلفون: Linda A. Lieberman, Nicholas Murgolo, Alex G. Therien, Gokul Swaminathan, Philip M. McKenna, Daniel J. Klein, Daria J. Hazuda, Bonnie J. Howell, David B. Olsen, Kenneth A. Koeplinger, Gregory C. Adam, Jessica A. Flynn

المصدر: PLoS Pathogens, Vol 17, Iss 2, p e1009225 (2021)
PLoS Pathogens

مصطلحات موضوعية: RNA viruses, Viral Diseases, Lung Development, Pulmonology, Coronaviruses, Organogenesis, Review, Disease, Virus Replication, Bioinformatics, Biochemistry, Medical Conditions, 0302 clinical medicine, Drug Discovery, Medicine, Biology (General), Pathology and laboratory medicine, Furin, 0303 health sciences, Respiratory distress, Drug discovery, Serine Endopeptidases, Proteases, Medical microbiology, Endocytosis, Enzymes, Drug repositioning, Infectious Diseases, Drug development, Viruses, SARS CoV 2, Pathogens, Viral Entry, SARS coronavirus, QH301-705.5, Immunology, Microbiology, Cell Line, Respiratory Disorders, 03 medical and health sciences, Drug Development, Viral entry, Virology, Genetics, Humans, Molecular Biology, Tropism, 030304 developmental biology, Medicine and health sciences, Biology and life sciences, SARS-CoV-2, business.industry, Organisms, Viral pathogens, Proteins, COVID-19, Covid 19, Virus Internalization, RC581-607, Cathepsins, Microbial pathogens, COVID-19 Drug Treatment, Viral Tropism, Respiratory Infections, Enzymology, Tissue tropism, Parasitology, Immunologic diseases. Allergy, business, Organism Development, Viral Transmission and Infection, 030217 neurology & neurosurgery, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe9afa61e647c5d21342ce0e67973a4Test
https://doi.org/10.1371/journal.ppat.1009225Test

المؤلفون: Jay A. Grobler, Abbas Walji, Paul J. Coleman, Min Xu, Timothy J. Hartingh, Natasa Pajkovic, John T. Sisko, David A. Powell, John M. Sanders, Michael D. Miller, Mark Embrey, Rada Vanessa L, Keith P. Moore, Daniel J. Klein, Nguyen Natalie, Izzat T. Raheem, Dubost David C, Guillaume Barbe, Louis-Charles Campeau, Daria J. Hazuda, John S. Wai, Thomas G. Steele, John D. Schreier, Jamie M. McCabe Dunn

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2038-2046

مصطلحات موضوعية: 0301 basic medicine, Pyridones, Clinical Biochemistry, Human immunodeficiency virus (HIV), Pharmaceutical Science, Integrase inhibitor, HIV Infections, HIV Integrase, Pharmacology, medicine.disease_cause, 01 natural sciences, Biochemistry, Strand transfer, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, HIV Integrase Inhibitors, Molecular Biology, biology, Organic Chemistry, Raltegravir, 0104 chemical sciences, Integrase, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, HIV-1, Aminal, biology.protein, Molecular Medicine, Lead compound, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3afda9a20f9b604f336f17e0d16627bTest
https://doi.org/10.1016Test/j.bmcl.2017.02.039

المؤلفون: Kenneth E. Rittle, Dorothy Levorse, James C. Barrow, Eric A. Price, Katherine Tugusheva, Ming Tain Lai, Abigail Wolfe, Dennis Colussi, Paul Zuck, Shaun R. Stauffer, Adam J. Simon, Samuel L. Graham, M. Katharine Holloway, Zhi Qiang Yang, Georgia B. McGaughey, Amy S. Espeseth, Phung L. Ngo, Beth Pietrak, Min Xu, Qian Huang, Joseph P. Vacca, Sethu Sankaranarayanan, Daria J. Hazuda, Sanjeev Munshi, Harold G. Selnick

المصدر: Journal of Medicinal Chemistry. 51:6259-6262

مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Molecular Structure, biology, Molecular model, Bicyclic molecule, Chemistry, Stereochemistry, Drug Evaluation, Preclinical, Hydrogen Bonding, Crystal structure, Crystallography, X-Ray, Imidazolidines, Chemical synthesis, Cocrystal, Structure-Activity Relationship, Enzyme, Piperidines, Enzyme inhibitor, Drug Discovery, biology.protein, Amyloid precursor protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Enzyme Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b39bb3a2bd901885cd23cf513dd12eTest
https://doi.org/10.1021/jm800914nTest

المؤلفون: Joseph P. Vacca, Linghang Zhuang, Lori J. Gabryelski, Terry A. Lyle, William A. Schleif, Peter J. Felock, Boyoung Kim, Lixia Jin, I.-W. Chen, Donnette D. Staas, Chris Culberson, Steven D. Young, Daria J. Hazuda, Thorsten E. Fisher, John S. Wai, Peter D. Williams, Mark Embrey, Rama Mallai, Joan D. Ellis

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5595-5599

مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Integrase inhibitor, Virus Replication, Biochemistry, Cell Line, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, HIV Integrase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, HIV, Benzene, biology.organism_classification, In vitro, Rats, Integrase, Enzyme, chemistry, Viral replication, Enzyme inhibitor, Pyrazines, Lentivirus, Microsomes, Liver, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7dd8e0e282073e0fa1b3f0f4f284aeTest
https://doi.org/10.1016Test/j.bmcl.2007.07.092

المؤلفون: Gregory Moyer, Linghang Zhuang, Lori J. Gabryelski, Marc V. Witmer, Lixia Jin, Jiunn H. Lin, William A. Schleif, Yvonne M. Leonard, Peter J. Felock, Mark Embrey, Nancy N. Tsou, Kara A. Stillmock, Joseph P. Vacca, Debbie S. Perlow, Steven D. Young, Bradley K. Wong, Carl F. Homnick, Timothy W. Funk, John S. Wai, Joan D. Ellis, Daria J. Hazuda, I.-W. Chen

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:4550-4554

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Integrase inhibitor, Crystallography, X-Ray, Virus Replication, Biochemistry, chemistry.chemical_compound, Benzyl Compounds, Drug Discovery, Animals, HIV Integrase Inhibitors, Naphthyridines, Uracil, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Dihydrouracil, Nucleotidyltransferase, In vitro, Rats, Integrase, Enzyme, Viral replication, Enzyme inhibitor, HIV-1, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee10371fe67e0664a66800a9d205a2a7Test
https://doi.org/10.1016Test/j.bmcl.2005.06.105

المؤلفون: Janet Lineberger, Emilio A. Emini, Julie A. DeMartino, Dooseop Kim, Michael W. Miller, Richard J. Budhu, Karen Henry, Renee Hrin, Gwen Carver, Lorraine Malkowitz, Anthony Carella, William A. Schleif, Malcolm MacCoss, Sandra L. Gould, Joseph Kessler, Daria J. Hazuda, Sander G. Mills, Christopher L. Lynch, Liping Wang, Jeffrey J. Hale, Martin S. Springer

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:2129-2134

مصطلحات موضوعية: Imidazopyridine, Pyrrolidines, Receptors, CCR5, Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, CCR5 receptor antagonist, Biochemistry, Pyrrolidine, chemistry.chemical_compound, Heterocyclic Compounds, Drug Discovery, Side chain, Animals, Humans, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, virus diseases, Biological activity, Rats, CCR5 Receptor Antagonists, Molecular Medicine, Piperidine, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7d85c01fc28b7691f984018117a231Test
https://doi.org/10.1016Test/j.bmcl.2005.02.030