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المؤلفون: Frederick W. Goldberg, Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan, M. Raymond V. Finlay, Beth Williamson, Marianne Schimpl, Alexander R. Harmer, Oladipupo B. Adeyemi, Pär Nordell, Anna S. Cronin, Mercedes Vazquez-Chantada, Derek Barratt, Antonio Ramos-Montoya, Elaine B. Cadogan, Barry R. Davies
المصدر: ACS Medicinal Chemistry Letters. 13:1295-1301
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cf9dfca39604357a47354a464d4b09f5Test
https://doi.org/10.1021/acsmedchemlett.2c00172Test -
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المؤلفون: Olga Obrezanova, Anton Martinsson, Tom Whitehead, Samar Mahmoud, Andreas Bender, Filip Miljković, Piotr Grabowski, Ben Irwin, Ioana Oprisiu, Gareth Conduit, Matthew Segall, Graham F. Smith, Beth Williamson, Susanne Winiwarter, Nigel Greene
المساهمون: Obrezanova, Olga [0000-0002-2144-4634], Bender, Andreas [0000-0002-6683-7546], Miljković, Filip [0000-0001-5365-505X], Segall, Matthew [0000-0002-2105-6535], Smith, Graham F [0000-0003-0393-3650], Winiwarter, Susanne [0000-0002-9808-1683], Apollo - University of Cambridge Repository
المصدر: Molecular Pharmaceutics. 19:1488-1504
مصطلحات موضوعية: Metabolic Clearance Rate, data imputation, Biological Availability, Pharmaceutical Science, rat pharmacokinetics, clearance, neural networks, Models, Biological, Rats, Machine Learning, concentration−time pharmacokinetic profiles, graph convolutions, Pharmaceutical Preparations, QSPR, compound design, Drug Discovery, Animals, Molecular Medicine, Pharmacokinetics, bioavailability
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9bd2b4cfbc81205355cb3ed27f5a7eTest
https://doi.org/10.1021/acs.molpharmaceut.2c00027Test -
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المؤلفون: David Longmire, Haley Woods, Phillip B Rawlins, Jessie Hao-Ru Hsu, Daniel H O' Donovan, Alexandra Borodovsky, Peng Wang, Sharan K Bagal, Shaun M Fillery, Peter Barton, Clare Gregson, Beth Williamson, Samuel C Nash, Andrew Pike, Jon A Read, Kurt Gordon Pike, Andrew Bloecher, Erin Code, Minhui Shen, Sameer Kawatkar, Youfeng Nai, Jia Tang, Chengzhi Li, James C. Robinson
المصدر: Journal of Medicinal Chemistry. 64:17146-17183
مصطلحات موضوعية: Methyltransferase, Protein subunit, Allosteric regulation, macromolecular substances, Ligands, Cell Line, Structure-Activity Relationship, Allosteric Regulation, Heterocyclic Compounds, Catalytic Domain, Drug Discovery, Animals, Humans, Enhancer of Zeste Homolog 2 Protein, Enzyme Inhibitors, Enhancer, Cell Proliferation, biology, Chemistry, EZH2, Polycomb Repressive Complex 2, Small molecule, Rats, Histone methyltransferase, biology.protein, Cancer research, Molecular Medicine, PRC2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbef686d9310c0393124b8f8df7ca38Test
https://doi.org/10.1021/acs.jmedchem.1c01161Test -
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المؤلفون: Filip Miljković, Andreas Bender, Beth Williamson, Andy Sykes, Martin Johnson, Anton Martinsson, Nigel Greene, Olga Obrezanova
المصدر: Molecular Pharmaceutics. 18:4520-4530
مصطلحات موضوعية: Drug, Protocol (science), Data curation, Drug discovery, business.industry, Computer science, media_common.quotation_subject, Cmax, Pharmaceutical Science, Machine learning, computer.software_genre, Pharmacokinetics, In vivo, Test set, Drug Discovery, Molecular Medicine, Artificial intelligence, business, computer, media_common
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::54447022988786738bcf709d604f55daTest
https://doi.org/10.1021/acs.molpharmaceut.1c00718Test -
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المؤلفون: Edward J. Hennessy, Marianne Schimpl, Emma Rivers, Paul D. Smith, Elizabeth Hardaker, Ann T. Doherty, Nichola L. Davies, Jon Travers, Qianxiu Zhu, Beth Williamson, Graham Smith, Lorraine Mooney, Helen Musgrove, Kristin Goldberg, Muireann Coen, Anne-Laure Lainé, Xiefeng Jiang, Philip Hopcroft, Yuting Zheng, Robert I Troup, George Hodgson, Nicola Lindsay, Lindsay McMurray, Olga Collingwood, Stephen D. Wilkinson, Sharon Tentarelli, Guang He, Philip B. Rawlins, Roshini Markandu, Jon Winter-Holt, Josephine Walton, Ankur Karmokar, J. Willem M. Nissink, Yumeng Mao, Dejian Yang, Alexander Pflug, Gary Fairley, Scott Boyd, Cheng Wang, Anne Jackson, Martin R. Brown, William McCoull, Neville McLean, Venkatesh Pilla Reddy
المصدر: Journal of Medicinal Chemistry. 64:13524-13539
مصطلحات موضوعية: chemistry.chemical_compound, Tumor microenvironment, Innate immune system, Chemistry, Kinase, In vivo, Drug Discovery, Pyridine, Lipophilicity, Cancer research, Molecular Medicine, Potency, Compound 32
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ae4c719e098004f12a5992670f8e8abcTest
https://doi.org/10.1021/acs.jmedchem.1c00920Test -
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المؤلفون: Jaidip Gill, Marie Moullet, Anton Martinsson, Filip Miljković, Beth Williamson, Rosalinda H. Arends, Venkatesh Pilla Reddy
المصدر: CPT: pharmacometricssystems pharmacologyREFERENCES. 11(12)
مصطلحات موضوعية: Machine Learning, Modeling and Simulation, Drug Discovery, Humans, Pharmacology (medical), Drug Interactions, Pharmacokinetics, Models, Biological
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d63e43d911449921ca94b4635e06d0dTest
https://pubmed.ncbi.nlm.nih.gov/36176050Test -
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المؤلفون: Beth Williamson, Lindsay McMurray, Scott Boyd, Olga Collingwood, Neville McLean, Jon Winter-Holt, Christina Chan, Aixiang Xue, William McCoull
المصدر: Molecular pharmaceutics. 19(7)
مصطلحات موضوعية: Benzylamines, c-Mer Tyrosine Kinase, Metabolic Clearance Rate, Drug Discovery, Biphenyl Compounds, Hepatocytes, Pharmaceutical Science, Molecular Medicine, Animals, Models, Biological, Rats
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c12cd8fce8e80988e1879d0c5fec0b7Test
https://pubmed.ncbi.nlm.nih.gov/35533086Test -
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المصدر: Drug Discovery Today. 25:1793-1800
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Mechanism (biology), business.industry, Administration, Oral, Proteins, Computational biology, 03 medical and health sciences, Drug Delivery Systems, 030104 developmental biology, 0302 clinical medicine, Pharmaceutical Preparations, Pharmacokinetics, 030220 oncology & carcinogenesis, Proteolysis, Drug Discovery, Humans, Medicine, business, Oral retinoid, Drug metabolism
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386b90be2147c5934da0dd545cc49b03Test
https://doi.org/10.1016/j.drudis.2020.07.013Test -
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المؤلفون: Frederick W. Goldberg, M. Raymond V. Finlay, Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan, Gail L. Wrigley, Marianne Schimpl, Martin R. Howard, Beth Williamson, Mercedes Vazquez-Chantada, Derek G. Barratt, Barry R. Davies, Elaine B. Cadogan, Antonio Ramos-Montoya, Emma Dean
المصدر: Journal of Medicinal Chemistry. 63:3461-3471
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6b43386329529371549eb2977979ceb2Test
https://doi.org/10.1021/acs.jmedchem.9b01684Test -
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المؤلفون: Barry Jones, Beth Williamson, Nicola Colclough, Rhys Dafydd Owen Jones, Adrian J. Fretland, Dermot F. McGinnity
المصدر: Current drug metabolism. 21(2)
مصطلحات موضوعية: Pharmacology, Drug, business.industry, Drug discovery, media_common.quotation_subject, In silico, Clinical Biochemistry, Drug Evaluation, Preclinical, Phases of clinical research, Administration, Oral, Antineoplastic Agents, Computational biology, Metabolic stability, Intestinal Absorption, Drug Discovery, Dose escalation, Medicine, Oncology drug, Animals, Humans, Drug Interactions, business, ADME, media_common
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe55ab60d2a092e7883c11f311be6a4cTest
https://pubmed.ncbi.nlm.nih.gov/32164508Test