-
1
المؤلفون: Mirunalini Ravichandran, Subhiksha Subramanian
المصدر: Fundamental & Clinical Pharmacology. 36:72-80
مصطلحات موضوعية: Pharmacology, Nervous system, Orexins, Drug discovery, Neuropeptides, digestive, oral, and skin physiology, Optogenetics, Biology, Orexin receptor, Receptors, G-Protein-Coupled, medicine.anatomical_structure, nervous system, Orexin Receptors, Sleep Initiation and Maintenance Disorders, mental disorders, medicine, Drug approval, Humans, Pharmacology (medical), Receptor, Neuroscience, hormones, hormone substitutes, and hormone antagonists, G protein-coupled receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3940a00d6a047f0695b9a1c4ed9a95caTest
https://doi.org/10.1111/fcp.12723Test -
2
المؤلفون: Ann M. Decker, Catherine M. Kotz, Vijayakumar Mavanji, Tiffany L. Langston, Dehui Zhang, Yanan Zhang, Danni L. Harris, David A. Perrey
المصدر: J Med Chem
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, medicine.medical_treatment, Intraperitoneal injection, CHO Cells, Molecular Dynamics Simulation, Pharmacology, 01 natural sciences, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, Orexin Receptors, Drug Discovery, medicine, Animals, Structure–activity relationship, Wakefulness, 030304 developmental biology, Sulfonamides, 0303 health sciences, Molecular Structure, biology, Chemistry, biology.organism_classification, medicine.disease, Small molecule, 0104 chemical sciences, Orexin, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Female, Sleep, Narcolepsy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931ff980a0192e08e857b44e3b894b07Test
https://doi.org/10.1021/acs.jmedchem.1c00841Test -
3
المؤلفون: Marieke Vringer, Birgitte Rahbek Kornum
المصدر: Expert Opinion on Therapeutic Targets. :1-14
مصطلحات موضوعية: Pharmacology, Cataplexy, business.industry, Mechanism (biology), Clinical Biochemistry, Excessive daytime sleepiness, Disease, Bioinformatics, medicine.disease, Orexin, Quality of life (healthcare), Drug development, Drug Discovery, medicine, Molecular Medicine, medicine.symptom, business, Narcolepsy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0901dd04cc8a878002255d4ccfda52Test
https://doi.org/10.1080/14728222.2021.1969361Test -
4
المؤلفون: Duffet, Loic, Tatarskiy, Petr V, Harada, Masaya, Williams, Elyse T, Hartrampf, Nina, Patriarchi, Tommaso
المساهمون: University of Zurich
المصدر: Cell Chemical Biology, 29 (12)
مصطلحات موضوعية: Pharmacology, Orexin-B, Neuropeptides, Photocage, G protein-coupled receptor, Genetically encoded sensors, Biosensor, Clinical Biochemistry, 10050 Institute of Pharmacology and Toxicology, 610 Medicine & health, Biochemistry, Drug Discovery, 570 Life sciences, biology, Molecular Medicine, Molecular Biology
وصف الملف: application/application/pdf; ZORA_pdf.pdf - application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660fde800848fdd970de55ebf84199e8Test
https://pubmed.ncbi.nlm.nih.gov/36481097Test -
5
المؤلفون: Anne E. Fitzgerald, Tatiana Koudriakova, Kevin J. Coe, Anthony Ndifor, Cathy Preville, Christine Dugovic, Neelakandha S. Mani, Nicholas I. Carruthers, Michele C. Rizzolio, Timothy W. Lovenberg, Brock T. Shireman, Diane Nepomuceno, Coate Heather R, Daniel J. Pippel, Brian Lord, Allison Brett Douglas, Curt A. Dvorak, Pascal Bonaventure
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Sleep wake, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Neuropeptide, Pharmacology, 01 natural sciences, Biochemistry, Orexin receptor, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, nervous system, mental disorders, Drug Discovery, Receptor, Mode of action, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b157e2b40c4b8187c17e0918f6f2afcTest
https://doi.org/10.1021/acsmedchemlett.0c00085Test -
6
المؤلفون: Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Ryuichiro Ohshita, Akihisa Tokuda, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Emi Hasegawa, Takeshi Sakurai, Yasuo Uchida, Tetsu Sato, Hiroaki Gouda, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
مصطلحات موضوعية: Pharmacology, Mice, Orexins, Structure-Activity Relationship, Orexin Receptors, Organic Chemistry, Drug Discovery, Animals, Orexin Receptor Antagonists, General Medicine, Heterocyclic Compounds, 4 or More Rings
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0571529b5d14b8ad54e10a712a84a9Test
https://doi.org/10.26434/chemrxiv-2021-08md1Test -
7
المؤلفون: Katherine Hopkins, Daniel Hoyer, Soumya Mukherjee, Jonathan E. Mangum, Dalia Ponce, Laura H. Jacobson
المصدر: Medicine in Drug Discovery, Vol 11, Iss, Pp 100102-(2021)
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Mass spectrometry, Chemistry, Neuropeptide, Orexin, Triple quadrupole mass spectrometer, Animal models, RS1-441, Orexin-A, Sleep deprivation, Mice, Cerebrospinal fluid, Targeted mass spectrometry, Endocrinology, Pharmacy and materia medica, Internal medicine, Drug Discovery, medicine, Pharmacology (medical), Circadian rhythm, medicine.symptom, Arousal, Orexins/hypocretins, Sleep
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3fc5213706014db381fb39cdf5d7a7Test
http://www.sciencedirect.com/science/article/pii/S2590098621000233Test -
8
المؤلفون: John Gatfield, Catherine Roch, Thierry Sifferlen, Jodi T. Williams, Alexander Treiber, Christoph Boss, Martin Bolli, Christine Brotschi, Bibia Heidmann, Francois Jenck
المصدر: ChemMedChem. 14:1257-1270
مصطلحات موضوعية: Oxadiazole, Pharmacology, 01 natural sciences, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Orexin Receptors, Drug Discovery, Animals, Cytochrome P-450 CYP3A, Humans, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Oxadiazoles, CYP3A4, 010405 organic chemistry, Organic Chemistry, Suvorexant, Antagonist, Azepines, Triazoles, Orexin receptor, Rats, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Orexin Receptor Antagonists, Wakefulness, Sleep, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b115f7c0f955cf770604ab0fdaa3d44Test
https://doi.org/10.1002/cmdc.201900242Test -
9
المؤلفون: Henri Xhaard, Erik A.A. Wallén, Jari Yli-Kauhaluoma, Jyrki P. Kukkonen, Teppo O. Leino, Lasse Karhu, Ainoleena Turku
المصدر: ChemMedChem. 14:965-981
مصطلحات موضوعية: Pharmacology, Indole test, Agonist, Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Chemistry, medicine.drug_class, Organic Chemistry, Biological activity, Potentiator, 01 natural sciences, Biochemistry, Orexin receptor, 0104 chemical sciences, 3. Good health, Orexin, 010404 medicinal & biomolecular chemistry, mental disorders, Drug Discovery, medicine, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Binding site, psychological phenomena and processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::61323be3ae0c6af0b57567aabae3d334Test
https://doi.org/10.1002/cmdc.201900074Test -
10
المؤلفون: Ainoleena Turku, Henri Xhaard, Erik A.A. Wallén, Jyrki P. Kukkonen, Jari Yli-Kauhaluoma, Teppo O. Leino
المساهمون: Faculty of Pharmacy, Pharmaceutical Design and Discovery group, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Jari Yli-Kauhaluoma / Principal Investigator, Jyrki Kukkonen / Principal Investigator, Veterinary Biochemistry and Cell Biology, Veterinary Biosciences, Departments of Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Department of Physiology, Medicum, Henri Xhaard / Principal Investigator, Erik Wallen / Principal Investigator
المصدر: European Journal of Medicinal Chemistry. 157:88-100
مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Stereochemistry, 116 Chemical sciences, SIGNAL-TRANSDUCTION, 01 natural sciences, Azulenes, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, PROTEIN-COUPLED RECEPTORS, Orexin Receptors, Drug Discovery, KINASE, medicine, Humans, Azulene, OX1, Receptor, Pharmacology, Orexin receptor, CA2+ INFLUX, Dose-Response Relationship, Drug, Molecular Structure, DERIVATIVES, 010405 organic chemistry, Organic Chemistry, Antagonist, PEPTIDES, Long-term potentiation, HAMSTER OVARY CELLS, General Medicine, Potentiator, 3. Good health, 0104 chemical sciences, Orexin, Sleep-wake regulation, 030104 developmental biology, chemistry, 317 Pharmacy, LIGANDS, Signal transduction, INHIBITORS
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf1f88ce88287ada5393d1c3286c86fTest
https://doi.org/10.1016/j.ejmech.2018.07.040Test