يعرض 1 - 5 نتائج من 5 نتيجة بحث عن '"Katsumi Higaki"', وقت الاستعلام: 0.75s تنقيح النتائج
  1. 1
    (5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B

    المؤلفون: Katsumi Higaki, Estelle Gallienne, Anna Biela-Banaś, Sophie Front, Olivier R. Martin, Amelia Morrone, Diana Ballhausen, Anna Caciotti, Julie Charollais-Thoenig, Stéphane Demotz, Patricie Burda

    المساهمون: University of Zurich, Martin, Olivier R

    المصدر: European Journal of Medicinal Chemistry. 126:160-170

    مصطلحات موضوعية: 0301 basic medicine, Protein Denaturation, Hot Temperature, Mutant, 610 Medicine & health, 03 medical and health sciences, Drug Discovery, Humans, Glycoside hydrolase, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Gangliosidosis, GM1, biology, Drug discovery, 3002 Drug Discovery, Organic Chemistry, Mucopolysaccharidosis IV, General Medicine, Fibroblasts, Hydrogen-Ion Concentration, beta-Galactosidase, 3004 Pharmacology, 030104 developmental biology, Enzyme, chemistry, Biochemistry, 10036 Medical Clinic, Cell culture, Drug Design, Chaperone (protein), Mutation, biology.protein, Epimer, Lysosomes, Selectivity, Imino Pyranoses, 1605 Organic Chemistry

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9533b0f69d6f920eceaafce0d89380bTest
    https://doi.org/10.1016/j.ejmech.2016.09.095Test


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  2. 2
    Potent chemical chaperone compounds for GM1-gangliosidosis: N-substituted (+)-conduramine F-4 derivatives

    المؤلفون: Eiji Nanba, Shinichi Kuno, Atsushi Takahashi, Seiichiro Ogawa, Katsumi Higaki

    المصدر: MedChemComm. 6:306-310

    مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, biology, Stereochemistry, GM1 Gangliosidosis, Organic Chemistry, Pharmaceutical Science, Biochemistry, Enzyme, chemistry, Chaperone (protein), Drug Discovery, biology.protein, Molecular Medicine, Chemical chaperone

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::10bd0e8a002ab519f7fcf4949af0cb82Test
    https://doi.org/10.1039/c4md00270aTest


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  3. 3
    Efficient stereoselective synthesis of 2-acetamido-1,2- dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme

    المؤلفون: Xavier Verdaguer, José M. García Fernández, Katsumi Higaki, Eiji Nanba, Alex de la Fuente, Antoni Riera, Carmen Ortiz Mellet, Rocío Rísquez-Cuadro

    المساهمون: Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Economía y Competitividad (MINECO). España, Junta de Andalucía, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), European Commission. Fondo Social Europeo (FSO), Universidad de Sevilla

    المصدر: Digital.CSIC. Repositorio Institucional del CSIC
    instname
    idUS. Depósito de Investigación de la Universidad de Sevilla

    مصطلحات موضوعية: Models, Molecular, 1-Deoxynojirimycin, Stereochemistry, Hexosaminidase inhibitors, Mutant, Molecular Conformation, Iminosugar, Chemistry Techniques, Synthetic, Tay-Sachs disease, 010402 general chemistry, 01 natural sciences, Drug Discovery, Humans, Hexosaminidase, Glycoside hydrolase, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, Stereoselective synthesis, Stereoisomerism, General Medicine, Pharmacological chaperones, Imino Sugars, 0104 chemical sciences, Hexosaminidases, Kinetics, Enzyme, chemistry, Biochemistry, sp2-iminosugars, Stereoselectivity

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5cdb2c357f4536852ffe09288c201aTest
    http://hdl.handle.net/10261/137497Test


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  4. 4
    Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts

    المؤلفون: José M. García Fernández, Katsumi Higaki, Alda Lisa Concia, Pere Clapés, M. Isabel García-Moreno, Teresa Mena-Barragán, Carmen Ortiz Mellet, Eiji Nanba

    المصدر: European journal of medicinal chemistry. 121

    مصطلحات موضوعية: Glycoside Hydrolases, Stereochemistry, Iminosugar, 010402 general chemistry, 01 natural sciences, Pyrrolidine, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Moiety, Humans, Enzyme Inhibitors, Pharmacology, Gaucher Disease, biology, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, General Medicine, Fibroblasts, 0104 chemical sciences, Imino Sugars, Pharmacological chaperone, chemistry, Biochemistry, Chaperone (protein), biology.protein, Triol, medicine.drug, Imino Pyranoses

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ff26fc321962d3a0dce4a4e17f3d25Test
    https://pubmed.ncbi.nlm.nih.gov/26361824Test


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  5. 5
    Conformationally-locked N -glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease

    المؤلفون: Javier Castilla, Yolanda Díaz, Sergio Castillón, Carmen Ortiz Mellet, Yoshiyuki Suzuki, Eiji Nanba, Rocío Rísquez, Kousaku Ohno, José M. García Fernández, Katsumi Higaki

    المساهمون: Universidad de Sevilla. Departamento de Química Orgánica, Enginyeria Química, Universitat Rovira i Virgili.

    المصدر: idUS. Depósito de Investigación de la Universidad de Sevilla
    instname
    Digital.CSIC. Repositorio Institucional del CSIC
    European Journal of Medicinal Chemistry
    Repositori Institucional de la Universitat Rovira i Virgili
    Universitat Rovira i virgili (URV)

    مصطلحات موضوعية: Glucocerebrosidase, Stereochemistry, Mutant, Gaucher disease, 0223-5234, Lysosomal storage disorders, Glucosides, Glycomimetic, Drug Discovery, Pharmacological chaperone, medicine, Carbohydrate Conformation, Humans, Glycoside hydrolase, Oxazoles, Pharmacology, chemistry.chemical_classification, Gaucher Disease, biology, Hydrogen bond, Organic Chemistry, Glycoside, General Medicine, chemistry, Chaperone (protein), Drug Design, Glycosidase inhibitor, biology.protein, Glucosylceramidase, medicine.drug, Molecular Chaperones

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ed469719b742072f818d2a8ae3c735Test


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