Comparison of Insulin Pump Therapy and Multiple Daily Injections Insulin Regimen in Patients with Type 1 Diabetes During Ramadan Fasting
| العنوان: | Comparison of Insulin Pump Therapy and Multiple Daily Injections Insulin Regimen in Patients with Type 1 Diabetes During Ramadan Fasting |
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| المؤلفون: | Saleh Aljaser, Yousef Al Saleh, Maram Alsubaiee, Reem Alamoudi, Ali Alqarni, Mohsen Eledrisi, Abdul Salam |
| المصدر: | Diabetes Technology & Therapeutics. 19:349-354 |
| بيانات النشر: | Mary Ann Liebert Inc, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Insulin pump, medicine.medical_specialty, endocrine system diseases, Injections, Subcutaneous, Endocrinology, Diabetes and Metabolism, Saudi Arabia, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Hypoglycemia, Hospitals, Military, Islam, Drug Administration Schedule, Cohort Studies, Young Adult, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, In patient, Prospective Studies, Holidays, Glycemic, Type 1 diabetes, business.industry, Continuous glucose monitoring, nutritional and metabolic diseases, Fasting, medicine.disease, Medical Laboratory Technology, Regimen, Diabetes Mellitus, Type 1, Hyperglycemia, Female, business, Follow-Up Studies |
| الوصف: | Fasting Ramadan carries a high risk for patients with type 1 diabetes (T1DM). Data on the optimum insulin regimen in these patients are limited.To compare glucose profiles in patients with T1DM who use continuous subcutaneous insulin infusion (CSII) compared with those who use multiple daily injections (MDI) insulin regimen during Ramadan fast. The primary outcome was rates of hypoglycemia. Other outcomes included glycemic control, number of days needed to break fasting, and acute glycemic complications.Patients with T1DM who were on CSII or MDI and decided to fast Ramadan were recruited. Glucose data collected using self-monitoring of blood glucose (SMBG) and continuous glucose monitoring (CGM) were compared in the two groups, CSII and MDI, and glucose control was assessed by measuring serum fructosamine levels.A total of 156 patients were recruited, 61 on CSII and 95 on MDI. There was no difference in the rate of mild hypoglycemia4.4 mmol/L (80 mg/dL) (8.6% ± 6.1% in the CSII group and 9.85% ± 9.34% in the MDI group, P = 0.96). The mean rate of severe hypoglycemia2.7 mmol/L (50 mg/dL) was also not different in both groups (0.99% ± 1.7% in the CSII group compared to 1.7% ± 4.7% in the MDI group, P = 0.23). There was no difference in glycemic control as measured by fructosamine levels or the number of days that patients have to stop fasting. Glucose variability was significantly better in CSII group (SMBG; standard deviation [SD] 66.9 ± 15.3 vs. 76.9 ± 29.9, P = 0.02) (CGM; SD 68.1 ± 19.6 vs. 78.7 ± 24.9, P = 0.04). No diabetic ketoacidosis was reported in either group.In patients with T1DM who fast Ramadan, there was no difference in rates of hypoglycemia or hyperglycemia between CSII and MDI. However, CSII was associated with less glucose variability. |
| تدمد: | 1557-8593 1520-9156 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b31dfaba45b56da349b895409640c7Test https://doi.org/10.1089/dia.2016.0418Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....99b31dfaba45b56da349b895409640c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578593 15209156 |
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