التفاصيل البيبلوغرافية
| العنوان: |
Cross-Reactive Antibody Responses to Novel H5Nx Influenza Viruses Following Homologous and Heterologous Prime-Boost Vaccination with a Prepandemic Stockpiled A(H5N1) Vaccine in Humans. |
| المؤلفون: |
Levine, Min Z., Holiday, Crystal, Feng Liu, Jefferson, Stacie, Gillis, Eric, Bellamy, Abbie R., Tumpey, Terrence, Katz, Jacqueline M., Liu, Feng |
| المصدر: |
Journal of Infectious Diseases; 2017 Supplement, Vol. 216, pS555-S5559, 5p |
| مصطلحات موضوعية: |
INFLUENZA A virus, H5N1 subtype, INFLUENZA A virus, MICROBIAL virulence, BLOOD agglutination, IMMUNOGLOBULINS, IMMUNE response, VACCINATION, INFLUENZA prevention, ANTIGEN-antibody reactions, IMMUNOMODULATORS, CLINICAL trials, DOSE-effect relationship in pharmacology, HEMAGGLUTINATION tests, IMMUNIZATION, INFLUENZA vaccines, VIRAL antibodies, ANTIBODY formation, THERAPEUTICS |
| مستخلص: |
Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.3.4.4) caused outbreaks in US poultry. We evaluated the potential of a stockpiled A(H5N1) A/Anhui/1/2005 (clade 2.3.4) vaccine to elicit cross-reactive antibody responses to these emerging viruses. Sera from subjects who received 2 doses of MF59-adjuvanted A/Anhui/1/2005, or 1 dose of MF59-adjuvanted A/Anhui/1/2005 following priming with a clade 1 vaccine were characterized by microneutralization assays and modified hemagglutination inhibition (HI) assays. Only heterologous prime-boost vaccination induced modest cross-reactive HI antibody responses to H5Nx viruses. Heterologous prime-boost may provide a more effective vaccination strategy to broaden the antibody responses to emerging viruses. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
