المؤلفون: Natalia Ninkina, Owen M. Peters, Natalie Connor-Robson, Kirill D. Chaprov, Holger B. Kramer, Dominic J. Withers, Arthur T. Kopylov, Vladimir L. Buchman, Steven Millership, Alex Montoya

المساهمون: Wellcome Trust ISSF Funding, Medical Research Council

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: MPTP toxicity, MPP+, 1-methyl-4-phenylpyridinium, animal diseases, Parkinson's disease, Dopamine, Vesicular monoamine transporter 2, Biochemistry, chemistry.chemical_compound, Mice, neurodegenerative disease, synapse, DAT, dopamine transporter, Synuclein Family, 11 Medical and Health Sciences, Mice, Knockout, vesicles, biology, Cell Death, MPTP, CLIP, crosslink immunoprecipitation, Dopaminergic, LFQ, label-free quantitation, PSM, peptide-spectrum match, Cell biology, SNpc, substantia nigra pars compacta, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, iBAQ, intensity-based absolute quantification, Synaptic Vesicles, 03 Chemical Sciences, TKO, triple α/β/γ-synuclein null mutant mice, Research Article, Biochemistry & Molecular Biology, FDR, false discovery rate, TH, tyrosine hydroxylase, MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Substantia nigra, transgenic mice, Synaptic vesicle, synuclein, beta-Synuclein, mental disorders, GO, Gene Ontology, Animals, Molecular Biology, AADC, aromatic l-amino acid decarboxylase, neurotransmitter vesicular uptake, dopaminergic neurons, Pars compacta, Cell Biology, 06 Biological Sciences, nervous system diseases, Vesicular monoamine transporter, chemistry, nervous system, VMAT-2, vesicular monoamine transporter 2, biology.protein, Parkinson’s disease, DTSSP, 3,3′-dithiobis(sulfosuccinimidylpropionate)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c25bdcdb04d42ed3e6e25fe31cef99Test
http://europepmc.org/articles/PMC8633583Test

المؤلفون: Qi Yuan Fan, Xi Min Fan, Ting Wang Xiong, Sheng Song, Jie Liu, Ying Luo, Yu Ming Cao

المصدر: Neurochemical Research

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Time Factors, Gene Expression, Substantia nigra, Biochemistry, Substantia nigra pars compacta (SNpc), Rats, Sprague-Dawley, Liver inflammation, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Internal medicine, Dopaminergic neuron loss, medicine, Manganism, Animals, Hepatic transporters, Neuroinflammation, Liver injury, Inflammation, Manganese, Original Paper, Microglia, Behavior, Animal, Pars compacta, Chemistry, Dopaminergic Neurons, Dopaminergic, Neurotoxicity, Brain, General Medicine, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Liver, Rotarod Performance Test, Neurotoxicity Syndromes, Chronic manganism, Chemical and Drug Induced Liver Injury, 030217 neurology & neurosurgery, Injections, Intraperitoneal

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e67d9584dff2637e5cac00dbe4a29dTest
https://pubmed.ncbi.nlm.nih.gov/32488470Test

المؤلفون: Arambakkam Janardhanam Vanisree, Margabandhu Gopi

المصدر: IBRO Reports
IBRO Reports, Vol 3, Iss C, Pp 1-8 (2017)

مصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, PtdIns(3,4,5)P3, Phosphatidylinositol 3,4,5-trisphosphate, PC, Phosphatidyl choline, NM, Neuromelanin, Striatum, PE, Phosphatidyl ethanolamine, Pharmacology, PD, Parkinson's disease, chemistry.chemical_compound, 0302 clinical medicine, TB, Toluidine blue dye, TBAHS, tetrabutyl ammonium hydrogen sulphate, MRM, Multiple reaction monitor, ANSA, 1 Amino-2 naphthol-4 sulfonic acid, Phospholipids, PtdIns(4,5)P2, Phosphatidylinositol 4,5-bisphosphate, General Neuroscience, Parkinsonism, Dopaminergic, Biochemistry, AD, Alzheimer's disease, NaCl, Sodium chloride, TLC, Thin layer chromatography, Substantia nigra, SM, Spingomyelin, Article, lcsh:RC321-571, 03 medical and health sciences, PI(3,5)P2, Phosphatidylinositol 3,5-bisphosphate, Rotenone, medicine, Pi, SNpc, Substantia nigra pars compacta, PtdIns5P, Phosphatidylinositol 5-phosphate, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, AFTC, Ammonium ferrothiocyanate, MS, Mass spectrometry, ROT, Rotenone, DA, Dopaminergic neuron, TEM, Transmission electron microscopy, DMSO, Dimethyl sulfoxide, Metabolism, medicine.disease, VBB, Victoria blue-B dye, HCl, Hydrochloric acid, 030104 developmental biology, chemistry, ESI, Electrospray ionization, Na.EDTA, Sodium Ethylenediaminetetraacetic acid, HRLCMS, High resolution liquid chromatography–mass spectrometry, PI, Phosphoinositide, PLs, Phospholipids, 030217 neurology & neurosurgery, Dye-lipid complex

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bff7286cc0964453a641f79e008bc0eTest
https://doi.org/10.1016/j.ibror.2017.06.001Test

المؤلفون: Paul C. Keane, Christopher Morris, P.J. Kahle, Peter S. Hanson, Fiona E. N. LeBeau, Ahmad Khundakar, Peter G. Blain, Sarah J. Judge, Philippa D. Hepplewhite, Lina Patterson

المصدر: Neuroscience letters 711, 134437 (2019). doi:10.1016/j.neulet.2019.134437
Neuroscience Letters

مصطلحات موضوعية: 0301 basic medicine, Male, Parkinson's disease, pathology [Dopaminergic Neurons], drug effects [Dopaminergic Neurons], toxicity [Trichloroethylene], TaClo, pathology [Parkinsonian Disorders], toxicity [Neurotoxins], CE, coefficient of error, Mice, 0302 clinical medicine, TaClo, 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline, Neurotoxin, ANOVA, analysis of variance, α-Synuclein, Chemistry, General Neuroscience, Neurodegeneration, Dopaminergic, DA, dopaminergic, pathology [Nerve Degeneration], SNpc, substantia nigra pars compacta, Substantia Nigra, alpha-Synuclein, metabolism [Neurotoxins], genetics [alpha-Synuclein], MPTP, 1-methy,4-phenyl, 1,2,3,6 tetrahyrdopyridine, Female, Genetically modified mouse, medicine.medical_specialty, DMSO, dimethylsulfoxide, TH, tyrosine hydroxylase, Neurotoxins, Substantia nigra, Mice, Transgenic, Article, 03 medical and health sciences, Parkinsonian Disorders, Internal medicine, medicine, TCE, trichloroethylene, Animals, Humans, metabolism [Trichloroethylene], ddc:610, pathology [Substantia Nigra], PD, Parkinson’s disease, Pars compacta, Dopaminergic Neurons, Wild type, medicine.disease, nervous system diseases, Trichloroethylene, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, nervous system, Nerve Degeneration, Mutation, Parkinson’s disease, drug effects [Substantia Nigra], 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c72fc6dc3fd8505e5e8d6afd86da507Test

المؤلفون: Emanuele Claudio Latagliata, Robert Nisticò, Howard H. Gu, Ada Ledonne, Stefano Puglisi-Allegra, Mauro Federici, Nicola Biagio Mercuri, Francesca Romana Rizzo, Andrea Romigi

مصطلحات موضوعية: Patch-Clamp Techniques, Dopamine Plasma Membrane Transport Proteins, Animals, SNpc, dopamine overflow, Benzhydryl Compounds, aCSF, dopamine transporter, Wakefulness-Promoting Agents, Dopamine, locomotor activation, constant potential amperometry, Cocaine, amperometry, DAT, substantia nigra pars compacta, Brain, Mice, i.p, Dopaminergic Neurons, intraperitoneally, Mice, Mutant Strains, artificial cerebrospinal fluid, modafinil, Motor Activity, CPA, dat, Substantia nigra, Striatum, Pharmacology, mental disorders, medicine, Dopamine transporter, biology, Chemistry, Pars compacta, General Neuroscience, Dopaminergic, Modafinil, Settore BIO/14, Mutant Strains, nervous system, biology.protein, Neuroscience, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4299c379e36dbb20b5892cf7f878cc9Test
http://hdl.handle.net/11573/556084Test

المؤلفون: Peter Redgrave, Eleanor J. Dommett, Véronique Coizet, Esther Marije Klop, Paul G. Overton

المساهمون: Savasta, Marc, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Psychology [Sheffield], University of Sheffield [Sheffield], School of Life, Health and Chemical Sciences [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Department of Neuroscience, University of Groningen [Groningen]-University Medical Centre - Anatomy Section, Wellcome Trust GR068021 Biotechnology and Biological Sciences Research Council BB/D019648/1 University of Sheffield Netherlands Organisation for Scientific Research

المصدر: Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 2010, 168 (1), pp.263-72. ⟨10.1016/j.neuroscience.2010.03.049⟩
Coizet, V, Dommett, E J, Klop, E M, Redgrave, P & Overton, P G 2010, ' The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain dopaminergic neurons ', Neuroscience, vol. 168, no. 1, pp. 263-272 . https://doi.org/10.1016/j.neuroscience.2010.03.049Test
Neuroscience, 168(1), 263-272. PERGAMON-ELSEVIER SCIENCE LTD

مصطلحات موضوعية: Male, NHS, normal horse serum, Dopamine, TX, Triton X 100, PB, phosphate buffer, PPTg, pedunculoponting tegmental nucleus, MESH: Neurons, Reticular formation, 0302 clinical medicine, Mesencephalon, Pons, RETICULAR-FORMATION, rat, MESH: Animals, nociception, Anesthetics, Local, MESH: GABA-A Receptor Antagonists, ANOVA, analysis of variance, Neurons, GLUTAMATERGIC NEURONS, 0303 health sciences, SUBSTANTIA-NIGRA, MESH: Electrophysiology, Chemistry, Muscimol, General Neuroscience, Dopaminergic, PHA-L, Phaseolus vulgaris leukoagglutinin, DA, dopaminergic, DORSAL-HORN NEURONS, MESH: Electric Stimulation, FOS-LIKE PROTEIN, PBN, parabrachial nucleus, Ventral tegmental area, Electrophysiology, Substantia Nigra, medicine.anatomical_structure, extracellular recording, LATERAL HABENULA, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Pain, SUPERIOR COLLICULUS, Research Paper, medicine.drug, LAMINA-I NEURONS, MESH: Rats, Neuroscience(all), TH, tyrosine hydroxylase, MESH: Substantia Nigra, Pain, Substantia nigra, MESH: Dopamine, VTA, ventral tegmental area, MESH: Anesthetics, Local, DAB, diaminobenzidine, 03 medical and health sciences, FLI, fos-like immunoreactivity, PBS, phosphate buffered saline, PSTH, peri-stimulus time interval histogram, medicine, Animals, GABA-A Receptor Antagonists, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], tract tracing, 030304 developmental biology, Parabrachial Nucleus, Pars compacta, SNPr, substantia nigra pars reticulata, NIGRA PARS COMPACTA, Lidocaine, MESH: Pons, Pain Mechanisms and Sensory Neuroscience, MESH: Mesencephalon, BDA, biotinylated dextran amine, Electric Stimulation, MESH: Male, Rats, VENTRAL TEGMENTAL AREA, MESH: Lidocaine, nervous system, RMTg, rostromedial tegmental nucleus, SNPc, substantia nigra pars compacta, BSA, bovine serum albumin, SD, standard deviation, Neuroscience, MESH: Female, 030217 neurology & neurosurgery, MESH: Muscimol

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b120cb1749301d1a3be1ccd2253e2b8Test
https://doi.org/10.1016/j.neuroscience.2010.03.049Test

المؤلفون: Radha Goh Nair-Roberts, Helen White-Cooper, Elizabeth Benson, Mark A. Ungless, S. D. Chatelain-Badie, J. P. Bolam

المصدر: Neuroscience

مصطلحات موضوعية: Male, RT-PCR, reverse transcriptase–polymerase chain reaction, Dopamine, IP, interpeduncular nucleus, lSN, lateral substantia nigra, Cell Count, PBS-T, phosphate-buffered saline containing 0.1% Tween 20, Rats, Sprague-Dawley, Stereotaxic Techniques, RLi, rostral linear nucleus, Mesencephalon, Basal ganglia, Tegmentum, gamma-Aminobutyric Acid, reward, HB, hybridization buffer, Neurons, GAD, glutamic acid decarboxylase, Glutamate Decarboxylase, General Neuroscience, GAD, Dopaminergic, SNpc, substantia nigra pars compacta, Ventral tegmental area, Substantia Nigra, RRF, retrorubral field, medicine.anatomical_structure, basal ganglia, SN, substantia nigra, medicine.drug, PBP, parabrachial nucleus, Tyrosine 3-Monooxygenase, Neuroscience(all), TH, tyrosine hydroxylase, PBS, phosphate-buffered saline, Glutamic Acid, vSN, ventral substantia nigra, Substantia nigra, midbrain, VGluT, vesicular glutamate transporter, Biology, Medium spiny neuron, VTA, ventral tegmental area, PN, paranigral nucleus, VGluT2, medicine, Animals, RNA, Messenger, IFN, interfascicular subnucleus of the ventral tegmental area, Pars compacta, Ventral Tegmental Area, Rats, Neuroanatomy, nervous system, Vesicular Glutamate Transport Protein 2, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0557dc4d7d3bb241739c2af10a37e66Test
http://ora.ox.ac.uk/objects/uuid:fe5b4b78-c6a9-4f83-9d93-c2aba5adb40bTest