يعرض 1 - 10 نتائج من 163 نتيجة بحث عن '"Tropane"', وقت الاستعلام: 0.98s تنقيح النتائج
  1. 1
    Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs

    المؤلفون: Danielle Krout, Akula Bala Pramod, Michael J. Tomlinson, James D. Foster, Rejwi Acharya Dahal, Mu Fa Zou, John R. Lever, L. Keith Henry, Comfort Boatang, Roxanne A. Vaughan, Amy Hauck Newman, Babita Sharma

    المصدر: Biochem Pharmacol

    مصطلحات موضوعية: 0301 basic medicine, Azides, Substance-Related Disorders, Swine, Stereochemistry, Photoaffinity Labels, Molecular Dynamics Simulation, Ligands, Peptide Mapping, Biochemistry, Article, Reuptake, Iodine Radioisotopes, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cocaine, Animals, Binding site, Cocaine binding, Dopamine transporter, Pharmacology, Dopamine Plasma Membrane Transport Proteins, Binding Sites, Molecular Structure, Photoaffinity labeling, biology, Tropane, Molecular Docking Simulation, Cross-Linking Reagents, 030104 developmental biology, chemistry, Docking (molecular), biology.protein, LLC-PK1 Cells, Mutant Proteins, Pharmacophore, Protein Binding, Tropanes

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cf1746a57566cffa45a5dd17210d46Test
    https://doi.org/10.1016/j.bcp.2017.07.015Test


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  2. 2
    The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation

    المؤلفون: Ara M. Abramyan, Sebastian Stolzenberg, Frank Noé, Claus J. Loland, Zheng Li, Lei Shi

    المصدر: ACS Chemical Neuroscience. 8:1735-1746

    مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Physiology, Stereochemistry, Cognitive Neuroscience, Dopamine Agents, Molecular Dynamics Simulation, medicine.disease_cause, Biochemistry, 03 medical and health sciences, Molecular dynamics, chemistry.chemical_compound, Abuse liability, medicine, Humans, Dopamine transporter, Benztropine, Dopamine Plasma Membrane Transport Proteins, Mutation, biology, Chemistry, Stereoisomerism, Transporter, Tropane, Cell Biology, General Medicine, Ligand (biochemistry), Markov Chains, 030104 developmental biology, Models, Chemical, biology.protein, Quantum Theory, Protein Binding

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a393adf652b251b3e4ac1ecb336fc8Test
    https://doi.org/10.1021/acschemneuro.7b00094Test


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  3. 3
    Perturbed Development of Striatal Dopamine Transporters in Fatty Versus Lean Zucker Rats: a Follow-up Small Animal PET Study

    المؤلفون: Eva Grill, Monika Pischetsrieder, Patrick J. Riss, Torsten Kuwert, Olaf Prante, Simone Maschauer, Paul Cumming

    المصدر: Molecular Imaging and Biology. 17:521-528

    مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Striatum, chemistry.chemical_compound, Dopamine, Internal medicine, Dopamine receptor D2, medicine, Animals, Radiology, Nuclear Medicine and imaging, Obesity, Receptor, Dopamine transporter, Dopamine Plasma Membrane Transport Proteins, biology, business.industry, Transporter, Tropane, Ligand (biochemistry), Corpus Striatum, Rats, Rats, Zucker, Endocrinology, Oncology, chemistry, Positron-Emission Tomography, biology.protein, Female, business, Follow-Up Studies, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82699ad8a8e4dee042e81f5586c46700Test
    https://doi.org/10.1007/s11307-014-0811-7Test


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  4. 4
    2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter

    المؤلفون: Weimin Conrad Hong, Amy Hauck Newman, Jonathan L. Katz, Paul L. Soto, Mu-Fa Zou, Theresa A. Kopajtic, Derek S. Wilkinson, Takato Hiranita, Carl R. Lupica

    المصدر: Journal of Pharmacology and Experimental Therapeutics. 349:297-309

    مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, medicine.medical_treatment, Self Administration, Stimulation, Motor Activity, Pharmacology, Rats, Sprague-Dawley, Drug Discovery and Translational Medicine, Mice, Radioligand Assay, chemistry.chemical_compound, Discrimination, Psychological, Cocaine, Receptor, Cannabinoid, CB1, Muscarinic acetylcholine receptor, medicine, Animals, Humans, Receptor, Dopamine transporter, Dopamine Plasma Membrane Transport Proteins, biology, Chemistry, Tropane, Isoxazoles, Corpus Striatum, Mice, Mutant Strains, Phenyltropane, HEK293 Cells, biology.protein, Molecular Medicine, Serotonin, Cannabinoid, human activities, Tropanes, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bf5354bca36eb8d5d5f4b6142b4d5cTest
    https://doi.org/10.1124/jpet.113.212738Test


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  5. 5
    Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal [123I]FP-CIT SPECT and histochemistry

    المؤلفون: Guido Hermanns, Lukas Maurer, Wolfgang H. Oertel, Günter U. Höglinger, Andrea Windolph, Martin Béhé, Andreas Matusch, Candan Depboylu

    المصدر: NeuroImage 79, 191-200 (2013). doi:10.1016/j.neuroimage.2013.04.076

    مصطلحات موضوعية: Male, Antiparkinson Agents, Levodopa, Mice, Pramipexole, administration & dosage [Dopamine Agonists], drug effects [Neuronal Plasticity], administration & dosage [Levodopa], Longitudinal Studies, Neuronal Plasticity, biology, Dopaminergic, Parkinson Disease, drug effects [Presynaptic Terminals], pharmacokinetics [Radiopharmaceuticals], Treatment Outcome, Neurology, Anesthesia, metabolism [Presynaptic Terminals], Dopamine Agonists, medicine.drug, medicine.medical_specialty, administration & dosage [Antiparkinson Agents], Cognitive Neuroscience, Presynaptic Terminals, metabolism [Parkinson Disease], Substantia nigra, Dopamine agonist, administration & dosage [Benzothiazoles], Dopamine, Internal medicine, medicine, Animals, ddc:610, Benzothiazoles, Dopamine transporter, Tomography, Emission-Computed, Single-Photon, Dopamine Plasma Membrane Transport Proteins, Tyrosine hydroxylase, business.industry, pharmacokinetics [Tropanes], drug therapy [Parkinson Disease], Mice, Inbred C57BL, Endocrinology, biology.protein, metabolism [Dopamine Plasma Membrane Transport Proteins], methods [Tomography, Emission-Computed, Single-Photon], Radiopharmaceuticals, business, Tropanes, 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb58d08aa14be81776806af21da0cb7fTest
    https://doi.org/10.1016/j.neuroimage.2013.04.076Test


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  6. 6
    Further structure–activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters

    المؤلفون: Dean Wade, Stacey A. Lomenzo, Abha Verma, Sari Izenwasser, Mark L. Trudell, Amy Housman, Shaine Cararas

    المصدر: Bioorganic & Medicinal Chemistry. 19:7551-7558

    مصطلحات موضوعية: Male, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Article, Rats, Sprague-Dawley, Bridged Bicyclo Compounds, Cocaine-Related Disorders, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Molecular Biology, Serotonin transporter, Dopamine transporter, Octane, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Norepinephrine Plasma Membrane Transport Proteins, biology, Organic Chemistry, Tropane, Transporter, Octanes, Ligand (biochemistry), Rats, Monoamine neurotransmitter, chemistry, Norepinephrine transporter, biology.protein, Molecular Medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8350c3e7330e1ef03d19c66f9e9dd384Test
    https://doi.org/10.1016/j.bmc.2011.10.028Test


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  7. 7
    Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors

    المؤلفون: Theresa A. Kopajtic, Paul L. Soto, Stephen J Kohut, Gianluigi Tanda, Jianjin Cao, Takato Hiranita, Amy Hauck Newman, Jonathan L. Katz

    المصدر: Journal of Pharmacology and Experimental Therapeutics. 339:662-677

    مصطلحات موضوعية: Male, Rimcazole, Hydrochloride, Sigma receptor, Carbazoles, Self Administration, Anisoles, Pharmacology, Rats, Sprague-Dawley, Cocaine-Related Disorders, Radioligand Assay, chemistry.chemical_compound, Cocaine, Dopamine Uptake Inhibitors, Piperidines, medicine, Animals, Receptors, sigma, Molecular Targeted Therapy, BD-1047, Dopamine transporter, Dopamine Plasma Membrane Transport Proteins, Oxalates, Propylamines, biology, Chemistry, Antagonist, Tropane, Rats, Nomifensine, Behavioral Pharmacology, biology.protein, Conditioning, Operant, Molecular Medicine, Reinforcement, Psychology, Antipsychotic Agents, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf78944c6bd3571fceec4f9096682871Test
    https://doi.org/10.1124/jpet.111.185025Test


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  8. 8
    Low or High Cocaine Responding Rats Differ in Striatal Extracellular Dopamine Levels and Dopamine Transporter Number

    المؤلفون: Gaynor A. Larson, Anna M. Nelson, Nancy R. Zahniser

    المصدر: Journal of Pharmacology and Experimental Therapeutics. 331:985-997

    مصطلحات موضوعية: Male, Microdialysis, Dopamine, Dopamine Plasma Membrane Transport Proteins, Striatum, Motor Activity, Pharmacology, Nucleus accumbens, Rats, Sprague-Dawley, Cocaine-Related Disorders, Radioligand Assay, chemistry.chemical_compound, Neuropharmacology, Cocaine, Reward, Extracellular, medicine, Animals, Dopamine transporter, Behavior, Animal, Dose-Response Relationship, Drug, biology, Tropane, Corpus Striatum, Rats, Disease Models, Animal, chemistry, biology.protein, Molecular Medicine, Extracellular Space, Psychology, Protein Binding, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6eb2eb9df5a0f46f4a9bc0a00e4383Test
    https://doi.org/10.1124/jpet.109.159897Test


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  9. 9
    Synthesis and structure–activity relationship of 3β-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters

    المؤلفون: Chunyang Jin, Hernán A. Navarro, F. Ivy Carroll

    المصدر: Bioorganic & Medicinal Chemistry. 17:5126-5132

    مصطلحات موضوعية: Nortropanes, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Article, Sulfone, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Norepinephrine Plasma Membrane Transport Proteins, Molecular Structure, Monoamine transporter, biology, Alkaloid, Organic Chemistry, Sulfoxide, Tropane, Monoamine neurotransmitter, chemistry, biology.protein, Molecular Medicine, Protein Binding, Tropanes

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09359274e1ea82e71550b37c5ac3689Test
    https://doi.org/10.1016/j.bmc.2009.05.052Test


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  10. 10
    An extended study of dimeric phenyl tropanes

    المؤلفون: Mikkel Due Petersen, Steffen Sinning, Signe Grann Hansen, Susan Nielsen, Christian Pedersen, Mikael Bols, Ove Wiborg, Henrik H. Jensen

    المصدر: Nielsen, S, Pedersen, C M, Hansen, S G, Petersen, M D, Sinning, S, Wiborg, O, Jensen, H H & Bols, M 2009, ' An extended study of dimeric phenyl tropanes ', Bioorganic & Medicinal Chemistry, vol. 17, no. 14, pp. 4900-9 . https://doi.org/10.1016/j.bmc.2009.06.007Test
    University of Copenhagen

    مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Diol, Triazole, Pharmaceutical Science, Diamines, Binding, Competitive, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Diamine, Amide, Drug Discovery, Humans, Moiety, Molecular Biology, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Norepinephrine Plasma Membrane Transport Proteins, Molecular Structure, Organic Chemistry, Tropane, chemistry, Molecular Medicine, Dimerization, Linker, Protein Binding, Tropanes

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ce41c5397e9a23acd73a92dc4b4a39Test
    https://doi.org/10.1016/j.bmc.2009.06.007Test


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