دورية أكاديمية
Depression reduces accuracy while Parkinsonism slows response time for processing positive feedback in patients with Parkinson’s disease with comorbid major depressive disorder tested on a probabilistic category-learning task
| العنوان: | Depression reduces accuracy while Parkinsonism slows response time for processing positive feedback in patients with Parkinson’s disease with comorbid major depressive disorder tested on a probabilistic category-learning task |
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| المؤلفون: | Herzallah, Mohammad M., Khdour, Hussain Y., Taha, Ahmad B., Elmashala, Amjad M., Mousa, Hamza N., Taha, Mohamad B., Ghanim, Zaid, Sehwail, Mahmud M., Misk, Adel J., Balsdon, Tarryn (R18259), Moustafa, Ahmed A. (R17078), Myers, Catherine E., Gluck, Mark A. |
| المساهمون: | The MARCS Institute (Host institution) |
| بيانات النشر: | Switzerland, Frontiers Research Foundation |
| سنة النشر: | 2017 |
| المجموعة: | University of Western Sydney (UWS): Research Direct |
| مصطلحات موضوعية: | XXXXXX - Unknown, Parkinson’s disease, depression, mental, patients, learning, feedback (psychology), dopamine |
| الوصف: | Major depressive disorder (MDD) is the most common non-motor manifestation of Parkinson’s disease (PD) affecting 50% of patients during their course of illness. However, little is known about the cognitive correlates of MDD in PD. Using a computer-based cognitive task that dissociates learning from positive and negative feedback, we tested four groups of subjects: (1) patients with PD who have MDD, (2) patients with PD without MDD, (3) matched patients with MDD alone (without PD), and (4) matched healthy control subjects. Further, we used a mathematical model of decision making to fit both choice and response time data, allowing us to detect and characterize differences between the groups that are not revealed by cognitive results. The groups did not differ in learning accuracy from negative feedback, but the MDD groups (PD patients with MDD, and patients with MDD alone) exhibited a selective impairment in learning accuracy from positive feedback when compared to the non-MDD groups (PD patients without MDD and healthy subjects). However, response time in positive feedback trials in the PD groups (both with and without MDD) was significantly slower than the non-PD groups (MDD and healthy groups). While faster response time usually correlates with poor learning accuracy, it was paradoxical in PD groups, with PD patients with MDD having impaired learning accuracy while PD patients without MDD having intact learning accuracy. Mathematical modeling showed that both MDD groups (PD with MDD and MDD alone) were significantly slower than non-MDD groups in the rate of accumulation of information for stimuli trained by positive feedback which can lead to lower response accuracy. Conversely, modeling revealed that both PD groups (PD with MDD and PD alone) require more evidence than other groups to make responses, thus leading to slower response times. These results suggest that PD patients with MDD exhibit cognitive profiles with mixed traits characteristic of both MDD and PD, furthering our understanding of both PD and MDD ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | Frontiers in Psychiatry--1664-0640 Vol. 8 No. 84 |
| DOI: | 10.3389/fpsyt.2017.00084 |
| الإتاحة: | https://doi.org/10.3389/fpsyt.2017.00084Test http://handle.westernsydney.edu.au:8081/1959.7/uws:40657Test |
| حقوق: | © 2017 the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0Test/). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| رقم الانضمام: | edsbas.7866E1FF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fpsyt.2017.00084 |
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