دورية أكاديمية
Endogenous opioid–dopamine neurotransmission underlie negative CBV fMRI signals
| العنوان: | Endogenous opioid–dopamine neurotransmission underlie negative CBV fMRI signals |
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| المؤلفون: | Shih, Yen-Yu I., Chiang, Yun-Chen, Shyu, Bai-Chuang, Jaw, Fu-Shan, Duong, Timothy Q., Chang, Chen |
| المصدر: | Experimental Neurology, 234(2) |
| سنة النشر: | 2012 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Neurotransmitter, Nervous system diseases, Neurotransmisión, Eticloprida, Eticlopride, Morphine, Naloxona, Morfina, Pathologie du système nerveux, Striatum, Imagerie RMN, Vasoconstricción, Neurotransmetteur, Vasoconstriction, fMRI, Dopamine, Neurotransmission, Imaginería RMN, Catecholamine, Nuclear magnetic resonance imaging, Catécholamine, Dopamina, CBV, Vasomotricité, Vasomotricity, Naloxone |
| الوصف: | Previous studies showed noxious unilateral forepaw electrical stimulation surprisingly evoked negative blood-oxygenation-level-dependent (BOLD), cerebral blood flow (CBF), and cerebral blood volume (CBV) fMRI responses in the bilateral striatum whereas the local neuronal spike and c-Fos activities increased. These negative responses are associated with vasoconstriction and appeared to override the increased hemodynamic responses that typically accompanied with increased neural activity. The current study aimed to investigate the role of μ-opioid system in modulating vasoconstriction in the striatum associated with noxious stimulation on a 4.7-Tesla MRI scanner. Specifically, we investigated: i) how morphine (a μ-opioid receptor agonist) affects the vasoconstriction in the bilateral striatum associated with noxious electrical forepaw stimulation in rats, and ii) how naloxone (an opioid receptor antagonist) and eticlopride (a dopamine D2/D3 receptor antagonist) modulates the morphine effects onwards. Injection of morphine enhanced the negative striatal CBV responses to noxious stimulation. Sequential injection of naloxone in the same animals abolished the stimulus-evoked vasoconstriction. In a separate group of animals, injection of eticlopride following morphine also reduced the vasoconstriction. Our findings suggested that noxious stimulation endogenously activated opioid and dopamine receptors in the striatum and thus leading to vasoconstriction. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/pegm-qk90Test; https://cdr.lib.unc.edu/downloads/794084420?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/794084420Test |
| DOI: | 10.17615/pegm-qk90 |
| الإتاحة: | https://doi.org/10.17615/pegm-qk90Test https://cdr.lib.unc.edu/downloads/794084420?file=thumbnailTest https://cdr.lib.unc.edu/downloads/794084420Test |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.90303804 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/pegm-qk90 |
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