التفاصيل البيبلوغرافية
| العنوان: |
Systematic review and meta-analysis of liver transplantation using grafts from deceased donors aged over 70 years. |
| المؤلفون: |
Dasari, Bobby V., Mergental, Hynek, Isaac, John R., Muiesan, Paolo, Mirza, Darius F., Perera, Thamara |
| المصدر: |
Clinical Transplantation; Dec2017, Vol. 31 Issue 12, pn/a-N.PAG, 9p |
| مصطلحات موضوعية: |
LIVER transplantation, SURGICAL complications, ORGAN donors, DISEASE incidence, SURVIVAL analysis (Biometry), SYSTEMATIC reviews, META-analysis |
| مستخلص: |
Introduction Due to the current organ shortage, nearly 20% of patients die waiting for a liver transplant ( LT). The average donor age is on the rise, and grafts from elderly donors are offered as extended criteria grafts. Methods This is a meta-analysis comparing the outcome differences of adult patients undergoing LT using grafts from <70-year-old donors vs >70-year-old donors. The primary end-points were graft and patient survival. Secondary outcomes were biliary and vascular complications as well as graft function. The odds ratio ( OR) is a summary statistic with the corresponding 95% confidence interval; P < .05 was considered to be statistically significant. Results Eight nonrandomized comparative studies with 4376 LT recipients were included. About 79.9% and 20.1% of the grafts were from <70-year-old and >70-year-old donors, respectively. Graft survival at 1 year was similar between the two groups ( P = .11), but there was better 3-year and 5-year graft survival in the >70-year-old group ( P = .006 and P < .0001, respectively). Patient survival was also similar between the groups at 1 year ( P = .54), but with better survival at 3-year and 5-year follow-ups ( P = .007 and P < .0001, respectively) in the >70-year-old group. There were no statistically significant differences in the incidence of biliary, vascular, and graft functional-related complications. Conclusion Liver grafts from selected >70-year-old donors do not pose added organ-specific risks and thus have comparable transplantation outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
