يعرض 1 - 10 نتائج من 17 نتيجة بحث عن '"Sug Hyung Lee"', وقت الاستعلام: 2.00s تنقيح النتائج
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    المصدر: Acta oncologica (Stockholm, Sweden). 48(7)

    الوصف: pathologic stage of IA. Her neuropsychiatric symptoms failed to abate despite surgery and a course of intravenous immunoglobulins. Fourteen days postoperatively, she was started on adjuvant chemotherapy with a standard chemotherapeutic regime of BEP, receiving a total of three cycles. Her dystonia became less prominent rapidly after initiation of her first cycle, but it was only after 20 days after commencement of chemotherapy that she regained orientation and was able to answer questions in a relevant and appropriate manner. She returned to work four months after completion of chemotherapy. These two cases highlight the role of chemotherapy as an adjunct to surgery in a multimodality approach to paraneoplastic encephalitis associated with teratoma. In the first patient, the temporal association is definitive where neuropsychiatric symptoms only developed after the teratomas were resected. These symptoms resolved completely following chemotherapy. Given that tumour foci were identified on the omentum and in the peritoneal fluid, it is conceivable there may have been residual disease after surgery resulting in a delayed onset of encephalitis. This would further support the role of chemotherapy as an adjunct to surgery. In the second patient, since both surgery and intravenous immunoglobulin was administered prior to chemotherapy, one cannot exclude the possibility that her improvement may have represented a delayed effect of treatment. However, a strong temporal association between initiation of chemotherapy and symptom improvement was noted. In a review of patients reported to have paraneoplastic encephalitis associated with immature ovarian teratomas in the English literature (Table I), only three of the ten patients received chemotherapy, with a fourth receiving cyclophosphamide only [1� 6]. The grade and stage of the disease as well as the details of treatment

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