دورية أكاديمية
Anti-alpha-actinin antibodies cross-react with Anti-ssDNA antibodies in active autoimmune hepatitis
| العنوان: | Anti-alpha-actinin antibodies cross-react with Anti-ssDNA antibodies in active autoimmune hepatitis |
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| المؤلفون: | Renaudineau, Y., Dalekos, G. N., Gueguen, P., Zachou, K., Youinou, P. |
| المصدر: | ://WOS:000256089200007 |
| سنة النشر: | 2008 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | autoimmune hepatitis type 1, anti-DNA, anti-alpha-actinin, LUPUS NEPHRITIS, DNA ANTIBODIES, LIVER-DISEASES, AUTOANTIBODIES, TARGET, Allergy, Immunology |
| الوصف: | Recently, we have observed that the association of anti-F-actin autoantibodies (Abs) with anti-alpha-actinin Abs (double reactivity) was correlated with liver disease activity in autoimmune hepatitis type 1 (AIH-1; Gueguen et al., J Clin Immunol 26:495-505, 2006). As anti-alpha-actinin Abs are also associated with anti-single-stranded (ss) DNA in 16 of 50 (32%) AIH-1 patients, compared with 16 of 401 (4.0%) liver disease control patients, we sought to characterize these Abs in AIH-1. When associated, anti-ssDNA Abs cross-react with anti-alpha-actinin Abs, but neither with anti-double-stranded DNA Abs nor with anti-F-actin Abs. Furthermore, anti-alpha-actinin Abs are associated with high-avidity anti-ssDNA Abs in AIH-1. In addition, double reactivity against alpha-actinin and ssDNA was correlated with clinical and histological activity of the disease and untreated AIH-1 patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1080-0549 |
| العلاقة: | http://hdl.handle.net/11615/32614Test |
| DOI: | 10.1007/s12016-007-8050-1 |
| الإتاحة: | https://doi.org/10.1007/s12016-007-8050-1Test http://hdl.handle.net/11615/32614Test |
| رقم الانضمام: | edsbas.764A45E6 |
| قاعدة البيانات: | BASE |
| تدمد: | 10800549 |
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| DOI: | 10.1007/s12016-007-8050-1 |