التفاصيل البيبلوغرافية
| العنوان: |
Therapeutic exposures and pubertal testicular dysfunction are associated with adulthood milestones and paternity after childhood cancer |
| المؤلفون: |
Korhonen, Melanie, Tainio, Juuso, Koskela, Mikael, Madanat-Harjuoja, Laura Maria, Jahnukainen, Kirsi |
| المساهمون: |
Children's Hospital, HUS Children and Adolescents |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
3122 Cancers, Childhood cancer survivors, Divorce, Follow-up, Male fertility, Marriage, Paternity, Therapeutic exposure |
| الوصف: |
Background: Childhood cancer therapy may cause long-term effects. This cross-sectional study evaluated adulthood milestones in male childhood cancer survivors (CCS). Methods: The study population comprised 252 male CCS with 6 to 42 years of survival diagnosed at the Children’s Hospital in Helsinki (1964–2000) at the age of 0 to 17 years. Sex-, age-, and area of residence–matched population controls were randomly selected from the Finnish national registries. Data on moving away from the parental home, marital status, offspring, and adoption in CCS were compared with the population controls. We analyzed the influence of chemotherapy and radiation exposures and testicular dysfunction (ever nontestosterone-substituted serum follicle stimulating hormone >15 IU/L, luteinizing hormone >15 IU/L, testosterone <2 ng/mL (5 nmol/L), need of testosterone replacement therapy, or testicular volume <12 mL at the end of puberty) during pubertal maturation on long-term social outcomes. Results: CCS moved away from their parental home as frequently as population controls (97.8% vs. 98.5%, p =.45). CCS were less likely to marry or live in a registered relationship (46.4% vs. 57.5%, p <.001), especially when diagnosed at a young age (<4 years). Among those married, the probability of divorce was similar between CCS and population controls (27.4% vs. 23.8%, p =.41). Survivors were less likely to sire a child (38.5% vs. 59.1%, p <.001) and more likely to adopt (2% vs. 0.4%, p =.015). Lower probability of paternity was associated with hematopoietic stem cell therapy, testicular radiation dose >6 Gy, pubertal signs of testicular dysfunction (nontestosterone-substituted serum follicle stimulating hormone >15 IU/L, luteinizing hormone >15 IU/L, testosterone <2 ng/mL (5 nmol/L), or need of testosterone replacement therapy during puberty, or testicular volume <12 mL at the end of puberty) or azoospermia after puberty. Conclusions: This study emphasizes the value of pubertal monitoring of testicular ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Swedish Childhood Cancer Foundation; ALF Stockholm County and the Karolinska Institute; state research funding of the Helsinki University Hospital; Finnish Cancer Society; Lasten Syoepaesaeaetioe Vaereen; Swedish Research Council; Finnish Pediatric Research Foundation; Korhonen , M , Tainio , J , Koskela , M , Madanat-Harjuoja , L M & Jahnukainen , K 2023 , ' Therapeutic exposures and pubertal testicular dysfunction are associated with adulthood milestones and paternity after childhood cancer ' , Cancer , vol. 129 , no. 22 , pp. 3633-3644 . https://doi.org/10.1002/cncr.34971Test; 85166944493; 79dc14cd-7904-44d7-83ea-151936871a27; http://hdl.handle.net/10138/567813Test; 001043931100001 |
| الإتاحة: |
http://hdl.handle.net/10138/567813Test |
| حقوق: |
cc_by_nc_nd ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.A6B3C044 |
| قاعدة البيانات: |
BASE |
