دورية أكاديمية
Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma
| العنوان: | Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma |
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| المؤلفون: | Sarton, Benjamine, Tauber, Clovis, Fridman, Estéban, Péran, Patrice, Riu, Beatrice, Vinour, Hélène, David, Adrian, Geeraerts, Thomas, Bounes, Fanny, Minville, Vincent, Delmas, Clément, Salabert, Anne-Sophie, Albucher, Jean, François, Bataille, Benoit, Olivot, Jean, Marc, Cariou, Alain, Naccache, Lionel, Payoux, Pierre, Schiff, Nicholas, Silva, Stein |
| المساهمون: | Toulouse NeuroImaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Pôle Anesthésie Réanimation CHU de Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Imaging, Brain & Neuropsychiatry (iBraiN), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Weill Medical College of Cornell University New York, Pôle Neurosciences CHU Toulouse, Service Cardiologie CHU Toulouse, Pôle Cardiovasculaire et Métabolique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Département Neurologie CHU Toulouse, Centre Hospitalier de Narbonne (CH Narbonne), Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Equipe Neuropsychologie et neuroimagerie fonctionnelle ICM Paris (PICNIC), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0006-8950. |
| بيانات النشر: | HAL CCSD Oxford University Press |
| سنة النشر: | 2024 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | disorders of consciousness, neuroimmune activation, TSPO PET scan, prognosis, traumatic brain injury, brain anoxia, mesocircuit, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | International audience ; The pathophysiological underpinnings of critically disrupted brain connectomes resulting in coma are poorly understood, but inflammation is potentially an important but still undervalued factor. Here we present a first-in-human prospective study using translocator protein 18 kDa (TSPO) radioligand (F18-DPA714) for PET imaging, to allow in vivo neuroimmune activation quantification on patients with coma (n = 17) following either anoxia or traumatic brain injuries and compare with age and sex-matched controls. Our findings yield novel evidence that an early inflammatory component that is predominantly located within key cortical and subcortical brain structures which are putatively implicated in consciousness emergence and maintain after severe brain injury (i.e. mesocircuit and frontoparietal networks). We observed that traumatic and anoxic patients with coma have distinct neuroimmune activation profiles, both in terms of intensity and spatial distribution. Finally, we demonstrated that both the total amount and the specifically distributed PET-measurable neuroinflammation within the brain mesocircuit were associated with patient’s potential of recovery. We suggest that our results can be developed for use both as a new neuroprognostication tool and as promising biometric to guide future clinical trials targeting glial activity very early after severe brain injury. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38412555; hal-04508517; https://hal.science/hal-04508517Test; https://hal.science/hal-04508517/documentTest; https://hal.science/hal-04508517/file/Sarton_2024.pdfTest; PUBMED: 38412555 |
| DOI: | 10.1093/brain/awae045/7615245 |
| الإتاحة: | https://doi.org/10.1093/brain/awae045/7615245Test https://hal.science/hal-04508517Test https://hal.science/hal-04508517/documentTest https://hal.science/hal-04508517/file/Sarton_2024.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.7E4D6980 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/brain/awae045/7615245 |
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