دورية أكاديمية
Clinical profile and management of patients with acute pulmonary thromboembolism – a single centre, large observational study from India
| العنوان: | Clinical profile and management of patients with acute pulmonary thromboembolism – a single centre, large observational study from India |
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| المؤلفون: | Thoddi Ramamurthy Muralidharan, Sankaran Ramesh, Balakrishnan Vinod Kumar, Aditya V. Ruia, Mohan Kumar, Akshaya Gopalakrishnan, Gurpreet S. Johal, Amit Hooda, Rohit Malhotra, Reza Masoomi, Mahalakshmi Ramadoss, Vinodhini Subramanian, Maria J. Kalsingh, Panchanatham Manokar, Jebaraj Rathinasamy, Shanmugasundram Sadhanandham, Jayanthy V. Balasubramaniyan, Preetam Krishnamurthy, Jayanthy S. Murthy, Sadagopan Thanikachalam, Nagendra Boopathy Senguttuvan |
| المصدر: | Pulmonary Circulation, Vol 11 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779 |
| الوصف: | Acute pulmonary thromboembolism is associated with high mortality, similar to that of myocardial infarction and stroke. We studied the clinical presentation and management of pulmonary thromboembolism in the Indian population. An analysis of 140 patients who presented with acute pulmonary thromboembolism at a large volume center in India from June 2015 through December 2018 was performed. The mean age of our study population was 50 years with 59% being male. Comorbidities including deep vein thrombosis, diabetes mellitus, hypertension, and chronic obstructive pulmonary disease were present in 52.9%, 40%, 35.7% and 7.14% of patients, respectively. Out of 140 patients, 40 (28.6%) patients had massive pulmonary thromboembolism, 36 (25.7%) sub-massive pulmonary thromboembolism, and 64 (45.7%) had low-risk pulmonary thromboembolism. Overall, in-hospital mortality was 25.7%. Multivariate regression analysis found chronic kidney disease and pulmonary thromboembolism severity to be the only independent risk factors. Thrombolysis was performed in 62.5% of patients with a massive pulmonary thromboembolism and 63.9% of patients with a sub-massive pulmonary thromboembolism. In the massive pulmonary thromboembolism group, patients receiving thrombolytic therapy had lower mortality compared with patients who did not receive therapy ( p =0.022), whereas this difference was not observed in patients in the sub-massive pulmonary thromboembolism group. We conclude that patients with acute pulmonary thromboembolism in India presented more than a decade earlier than our western counterparts, and it was associated with poor clinical outcomes. Thrombolysis was associated with significantly reduced in-hospital mortality in patients with massive pulmonary thromboembolism. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-8940 20458940 |
| العلاقة: | https://doaj.org/toc/2045-8940Test |
| DOI: | 10.1177/2045894021992678 |
| الوصول الحر: | https://doaj.org/article/c223dba93bc341389d4429408d3aa8c7Test |
| رقم الانضمام: | edsdoj.223dba93bc341389d4429408d3aa8c7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20458940 |
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| DOI: | 10.1177/2045894021992678 |