دورية أكاديمية
Dysglycemias in patients admitted to ICUs with severe acute respiratory syndrome due to COVID-19 versus other causes - a cohort study
| العنوان: | Dysglycemias in patients admitted to ICUs with severe acute respiratory syndrome due to COVID-19 versus other causes - a cohort study |
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| المؤلفون: | Rosângela Roginski Réa, Rafaella Stradiotto Bernardelli, Amanda Christina Kozesinski-Nakatani, Marcia Olandoski, Marcelo José Martins-Junior, Mirella Cristine Oliveira, Álvaro Réa-Neto |
| المصدر: | BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-14 (2023) |
| بيانات النشر: | BMC |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | COVID-19, Critical illness, Intensive care units, Hyperglycemia, Glycemic control, Diseases of the respiratory system, RC705-779 |
| الوصف: | Background Dysglycemias have been associated with worse prognosis in critically ill patients with COVID-19, but data on the association of dysglycemia with COVID-19 in comparison with other forms of severe acute respiratory syndrome are lacking. This study aimed to compare the occurrence of different glycemic abnormalities in patients with severe acute respiratory syndrome and COVID-19 admitted to intensive care units versus glycemic abnormalities in patients with severe acute respiratory syndrome from other causes, to evaluate the adjusted attributable risk associated with COVID-19 and dysglycemia and to assess the influence of these dysglycemias on mortality. Methods We conducted a retrospective cohort of consecutive patients with severe acute respiratory syndrome and suspected COVID-19 hospitalized in intensive care units between March 11 and September 13, 2020, across eight hospitals in Curitiba-Brazil. The primary outcome was the influence of COVID-19 on the variation of the following parameters of dysglycemia: highest glucose level at admission, mean and highest glucose levels during ICU stay, mean glucose variability, percentage of days with hyperglycemia, and hypoglycemia during ICU stay. The secondary outcome was the influence of COVID-19 and each of the six parameters of dysglycemia on hospital mortality within 30 days from ICU admission. Results The sample consisted of 841 patients, of whom 703 with and 138 without COVID-19. Comparing patients with and without COVID-19, those with COVID-19 had significantly higher glucose peaks at admission (165 mg/dL vs. 146 mg/dL; p = 0.002) and during ICU stay (242 mg/dL vs. 187md/dL; p < 0.001); higher mean daily glucose (149.7 mg/dL vs. 132.6 mg/dL; p < 0.001); higher percentage of days with hyperglycemia during ICU stay (42.9% vs. 11.1%; p < 0.001); and greater mean glucose variability (28.1 mg/dL vs. 25.0 mg/dL; p = 0.013). However, these associations were no longer statistically significant after adjustment for Acute Physiology and Chronic ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2466 |
| العلاقة: | https://doi.org/10.1186/s12890-023-02439-yTest; https://doaj.org/toc/1471-2466Test; https://doaj.org/article/45eb643500264d61bd353d1c400044b3Test |
| DOI: | 10.1186/s12890-023-02439-y |
| الإتاحة: | https://doi.org/10.1186/s12890-023-02439-yTest https://doaj.org/article/45eb643500264d61bd353d1c400044b3Test |
| رقم الانضمام: | edsbas.BD8C507F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712466 |
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| DOI: | 10.1186/s12890-023-02439-y |