دورية أكاديمية
Biological Therapy in Systemic Lupus Erythematosus
| العنوان: | Biological Therapy in Systemic Lupus Erythematosus |
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| المؤلفون: | Mariana Postal, Lilian TL Costallat, Simone Appenzeller |
| المصدر: | International Journal of Rheumatology, Vol 2012 (2012) |
| بيانات النشر: | Hindawi Limited, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Systemic lupus erythematosus (SLE) is a prototypic inflammatory autoimmune disorder characterized by multisystem involvement and fluctuating disease activity. Symptoms range from rather mild manifestations such as rash or arthritis to life-threatening end-organ manifestations. Despite new and improved therapy having positively impacted the prognosis of SLE, a subgroup of patients do not respond to conventional therapy. Moreover, the risk of fatal outcomes and the damaging side effects of immunosuppressive therapies in SLE call for an improvement in the current therapeutic management. New therapeutic approaches are focused on B-cell targets, T-cell downregulation and costimulatory blockade, cytokine inhibition, and the modulation of complement. Several biological agents have been developed, but this encouraging news is associated with several disappointments in trials and provide a timely moment to reflect on biologic therapy in SLE. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-9260 1687-9279 |
| العلاقة: | https://doaj.org/toc/1687-9260Test; https://doaj.org/toc/1687-9279Test |
| DOI: | 10.1155/2012/578641 |
| الوصول الحر: | https://doaj.org/article/0514330896d54b16810edbc6428986f4Test |
| رقم الانضمام: | edsdoj.0514330896d54b16810edbc6428986f4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16879260 16879279 |
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| DOI: | 10.1155/2012/578641 |