التفاصيل البيبلوغرافية
| العنوان: |
Association of intrauterine growth restriction and low birth weight with acute kidney injury in preterm neonates. |
| المؤلفون: |
Sinelli, Mariateresa, Zannin, Emanuela, Doni, Daniela, Ornaghi, Sara, Acampora, Eleonora, Roncaglia, Nadia, Vergani, Patrizia, Ventura, Maria Luisa |
| المصدر: |
Pediatric Nephrology; Sep2023, Vol. 38 Issue 9, p3139-3144, 6p, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
PATENT ductus arteriosus, MULTIPLE regression analysis, FETAL growth retardation, RETROSPECTIVE studies, ACQUISITION of data, GESTATIONAL age, LOW birth weight, RISK assessment, MEDICAL records, DESCRIPTIVE statistics, ACUTE kidney failure, CREATININE, DISEASE risk factors, DISEASE complications |
| مستخلص: |
Background: Preterm birth alters nephrogenesis and reduces the total nephron number. Intrauterine growth restriction (IUGR) seems to worsen nephron loss, but only a few studies have investigated its role in neonatal kidney impairment. We investigated whether IUGR, defined as reduced estimated fetal growth and/or placental flow alterations and low birth weight z-score, increases the risk of developing acute kidney injury (AKI) in very preterm infants. Methods: We performed a retrospective study including infants born with a birth weight (BW) ≤ 1500 g and/or gestational age (GA) ≤ 32 weeks admitted to our center between January 2016 and December 2021. Neonatal AKI was defined according to the neonatal KDIGO classification based on the decline of urine output and/or creatinine elevation. We used multivariable linear regressions to verify the association between AKI and GA, BW z-score, IUGR definition, and hemodynamically significant patent ductus arteriosus (PDA). Results: We included 282 infants in the analysis, with a median (IQR) GA = 29.4 (27.4, 31.3) weeks, BW = 1150 (870, 1360) g, and BW z-score = − 0.57 (− 1.64, 0.25). AKI was diagnosed in 36 (13%) patients, and 58 (21%) had PDA. AKI was significantly associated with BW z-score (beta (std. error) = − 0.08 (0.03), p = 0.008) and severe IUGR (beta (std. error) = 0.21 (0.08), p = 0.009), after adjusting for GA and PDA. Conclusions: Our data suggest that low BW z-score and IUGR could represent adjunctive risk factors for kidney impairment in preterm babies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
