دورية أكاديمية
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.
| العنوان: | Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal. |
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| المؤلفون: | Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, Lopez, Jose I, Nicol, David, O'Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin, Watkins, Thomas BK, Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F, Reznik, Ed, Hsieh, James J, Richmond, Todd A, Mayhew, George F, Hill, Samantha M, McNally, Catherine D, Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L, Alexander, Nelson R, Swanton, Charles, PEACE, TRACERx Renal Consortium |
| بيانات النشر: | Elsevier BV //dx.doi.org/10.1016/j.cell.2018.03.057 Cell |
| سنة النشر: | 2018 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | chromosome instability, cytoreductive nephrectomy, evolution of metastasis, loss of 9p, metastasectomy, metastasis, oligometastasis, renal cell cancer, solitary metastasis, Adult, Aged, 80 and over, Biomarkers, Biopsy, Carcinoma, Renal Cell, Chromosome Mapping, Chromosomes, Human, Pair 14, Pair 9, Disease Progression, Female, Humans, Kidney Neoplasms, Longitudinal Studies, Male, Middle Aged, Mutation, Neoplasm Metastasis |
| الوصف: | Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure. By contrast, we observed attenuated progression in cases characterized by high primary tumor heterogeneity, with metastatic competence acquired gradually and initial progression to solitary metastasis. Finally, we observed early divergence of primitive ancestral clones and protracted latency of up to two decades as a feature of pancreatic metastases. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/278622Test |
| DOI: | 10.17863/CAM.25963 |
| الإتاحة: | https://doi.org/10.17863/CAM.25963Test https://www.repository.cam.ac.uk/handle/1810/278622Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.BF44E12F |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.25963 |
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