دورية أكاديمية
Optimal Bronchodilation for COPD Patients: Are All Long-Acting β2-Agonist/Long-Acting Muscarinic Antagonists the Same?
| العنوان: | Optimal Bronchodilation for COPD Patients: Are All Long-Acting β2-Agonist/Long-Acting Muscarinic Antagonists the Same? |
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| المؤلفون: | Marc Miravitlles, M.D., Seungjae Baek, M.D., Vatsal Vithlani, M.Pharm., Rahul Lad, Ph.D. |
| المصدر: | Tuberculosis and Respiratory Diseases, Vol 81, Iss 3, Pp 198-215 (2018) |
| بيانات النشر: | The Korean Academy of Tuberculosis and Respiratory Diseases, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | asian, pulmonary disease, chronic obstructive, disease management, korea, Diseases of the respiratory system, RC705-779 |
| الوصف: | Bronchodilators provide improvements in lung function and reductions in symptoms and exacerbations, and are the mainstay of pharmacological management of chronic obstructive pulmonary disease (COPD). The Global Initiative for Chronic Obstructive Lung Disease strategy recommends the use of a combination of long-acting β2-agonist/long-acting muscarinic antagonists (LABA/LAMA) as the first-line treatment option in the majority of symptomatic patients with COPD. This review provides an indirect comparison of available LABA/LAMA fixed-dose combinations (FDCs) through discussion of important efficacy and safety data from the key literature, with the objective of providing physicians with a framework for informed decision-making. LABA/LAMA FDCs provided greater benefits compared with placebo and similar or greater benefits compared with tiotropium and salmeterol/fluticasone in improving lung function, dyspnea, health-related quality of life, reducing rescue medication use and preventing exacerbations, although with some variability in efficacy between individual FDCs; further, tolerability profiles were comparable among LABA/LAMA FDCs. However, there is a disparity in the amount of evidence generated for different LABA/LAMA FDCs. Thus, this review shows that all LABA/LAMA FDCs may not be the same and that care should be taken when extrapolating individual treatment outcomes to the entire drug class. It is important that physicians consider the efficacy gradient that exists among LABA/LAMA FDCs, and factors such as inhaler devices and potential biomarkers, when choosing the optimal bronchodilator treatment for long-term management of patients with COPD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1738-3536 2005-6184 |
| العلاقة: | https://e-trd.org/search.php?where=aview&id=10.4046/trd.2018.0040&code=0003TRD&vmode=FULLTest; https://doaj.org/toc/1738-3536Test; https://doaj.org/toc/2005-6184Test |
| DOI: | 10.4046/trd.2018.0040&code=0003TRD&vmode=FULL |
| الوصول الحر: | https://doaj.org/article/4c1449b2541d495c93b9d2015677de6fTest |
| رقم الانضمام: | edsdoj.4c1449b2541d495c93b9d2015677de6f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17383536 20056184 |
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| DOI: | 10.4046/trd.2018.0040&code=0003TRD&vmode=FULL |