التفاصيل البيبلوغرافية
| العنوان: |
Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections. |
| المؤلفون: |
Bauer, Dirk1, Keller, Jessica2, Alt, Mira2, Schubert, Axel3, Aufderhorst, Ulrich Wilhelm2, Palapys, Vivien2, Kasper, Maren1, Heilingloh, Christiane Silke4, Dittmer, Ulf2, Laffer, Björn1, Eis-Hübinger, Anna Maria5, Verjans, Georges M.6, Heiligenhaus, Arnd1,7, Roggendorf, Michael2,8, Krawczyk, Adalbert2 adalbert.krawczyk@uni-due.de |
| المصدر: |
Virology. Dec2017, Vol. 512, p194-200. 7p. |
| مصطلحات موضوعية: |
*MONOCLONAL antibodies, *ACYCLOVIR, *HERPES simplex, *IMMUNOTHERAPY, *DISEASE incidence, *GLYCOPROTEINS, *THERAPEUTICS |
| مستخلص: |
The increasing incidence of aciclovir- (ACV) resistant strains in patients with ocular herpes simplex virus (HSV) infections is a major health problem in industrialized countries. In the present study, the humanized monoclonal antibody (mAb) hu2c targeting the HSV-1/2 glycoprotein B was examined for its efficacy towards ACV-resistant infections of the eye in the mouse model of acute retinal necrosis (ARN). BALB/c mice were infected by microinjection of an ACV-resistant clinical isolate into the anterior eye chamber to induce ARN and systemically treated with mAb hu2c at 24 h prior (pre-exposure prophylaxis) or at 24, 40, and 56 h after infection (post-exposure immunotherapy). Mock treated controls and ACV-treated mice showed pronounced retinal damage. Mice treated with mAb hu2c were almost completely protected from developing ARN. In conclusion, mAb hu2c may become a reliable therapeutic option for drug/ACV-resistant ocular HSV infections in humans in order to prevent blindness. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder