Survival in Patients with Neuroendocrine Tumours of the Small Intestine: Nomogram Validation and Predictors of Survival
| العنوان: | Survival in Patients with Neuroendocrine Tumours of the Small Intestine: Nomogram Validation and Predictors of Survival |
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| المؤلفون: | Sonja Levy, M. R. Vriens, Margot E T Tesselaar, Linde M. van Veenendaal, Gerlof D. Valk, Koert F. D. Kuhlmann, Wieke H M Verbeek, José G van den Berg, Catharina M. Korse, Emilie C H Breekveldt |
| المصدر: | Journal of Clinical Medicine Volume 9 Issue 8 Journal of Clinical Medicine, Vol 9, Iss 2502, p 2502 (2020) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, lcsh:Medicine, Liver tests, Article, Disease course, Unmet needs, nomogram, 03 medical and health sciences, 0302 clinical medicine, Neuroendocrine tumours, Internal medicine, medicine, In patient, 030304 developmental biology, 0303 health sciences, business.industry, lcsh:R, General Medicine, Nomogram, Small intestine, small-intestine, prediction model, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Treatment strategy, prognosis, business |
| الوصف: | Neuroendocrine tumours of the small intestine (SI-NETs) are rare and heterogeneous. There is an unmet need for prognostication of disease course and to aid treatment strategies. A previously developed nomogram based on clinical and tumour characteristics aims to predict disease-specific survival (DSS) in patients with a SI-NET. We aimed to validate the nomogram and identify predictors of survival. Four hundred patients with a grade 1 or 2 SI-NET were included, between January 2000 and June 2016. Predicted 5- and 10-year survival was compared to actual DSS. Multivariable analysis identified predictors for actual DSS. We found that in low-, medium- and high-risk groups 5-year nomogram DSS vs. actual DSS was 0.86 vs. 0.82 (p < 0.001), 0.52 vs. 0.71 (p < 0.001) and 0.26 vs. 0.53 (p < 0.001), respectively. Ten-year nomogram DSS vs. actual DSS was 0.68 vs. 0.69 (p < 0.001), 0.40 vs. 0.50 (p < 0.001) and 0.20 vs. 0.35 (p < 0.001), respectively. Age, WHO-performance score of 2, Ki-67 index &ge 10, unknown primary tumour, CgA > 6x ULN and elevated liver tests were identified as independent predictors for a worse DSS. This shows that the nomogram was able to differentiate, but underestimated DSS for patients with a SI-NET. Improvement of prognostication incorporating new emerging biomarkers is necessary to adequately estimate survival. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| DOI: | 10.3390/jcm9082502 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1eff302be0c3883fb14667d4699b536Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1eff302be0c3883fb14667d4699b536 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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| DOI: | 10.3390/jcm9082502 |