Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma
| العنوان: | Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma |
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| المؤلفون: | Ian Barak, Gavin Loitsch, Sascha A. Tuchman, Megan Dupuis, Zhiguo Li, Parker Mathews, Barry Paul, Yubin Kang, Daniel Feinberg |
| المصدر: | JCO Oncol Pract |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Treatment response, Pediatrics, medicine.medical_specialty, Oncology (nursing), business.industry, Health Policy, Point-of-care testing, MEDLINE, Retrospective cohort study, medicine.disease, ORIGINAL CONTRIBUTIONS, Cost of Illness, Oncology, Point-of-Care Testing, Chart review, Cost of illness, Humans, Medicine, Multiple Myeloma, business, Disease burden, Multiple myeloma, Retrospective Studies |
| الوصف: | PURPOSE: We performed a retrospective chart review on 393 patients with multiple myeloma (MM) to determine the utility of the gamma gap (GG). METHODS: We calculated the difference between a patient’s total serum protein and albumin as a point-of-care test for assessing disease status in MM. RESULTS: GG is highly correlated with the level of M-spike, and the change in GG correlates with myeloma treatment response. In addition, fitted linear models were established that allow for the calculation of M-protein level from the GG within hours from blood draw. CONCLUSION: Our study has important implications in the care of MM, particularly in countries/areas with limited resources. |
| تدمد: | 2688-1535 2688-1527 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d7965cef7769ad6891dba9aeeb687dTest https://doi.org/10.1200/jop.19.00517Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f8d7965cef7769ad6891dba9aeeb687d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26881535 26881527 |
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