دورية أكاديمية
The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project).
| العنوان: | The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project). |
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| المؤلفون: | Helliwell PS, Fitzgerald O, Fransen J, Gladman DD, Kreuger GG, Callis Duffin K, McHugh N, Mease PJ, Strand V, Waxman R, Azevedo VF, Beltran Ostos A, Carneiro S, Cauli A, Espinoza LR, Flynn JA, Hassan N, Healy P, Kerzberg EM, Lee YJ, Marchesoni A, Marzo Ortega H, Porru G, Moreta EG, Nash P, Raffayova H, Ranza R, Raychaudhuri SP, Roussou E, Scarpa R, Song YW, Soriano ER, Tak PP, Ujfalussy I, de Vlam K, Walsh JA, LUBRANO DI SCORPANIELLO, Ennio |
| المساهمون: | Helliwell, P, Fitzgerald, O, Fransen, J, Gladman, Dd, Kreuger, Gg, Callis Duffin, K, Mchugh, N, Mease, Pj, Strand, V, Waxman, R, Azevedo, Vf, Beltran Ostos, A, Carneiro, S, Cauli, A, Espinoza, Lr, Flynn, Ja, Hassan, N, Healy, P, Kerzberg, Em, Lee, Yj, LUBRANO DI SCORPANIELLO, Ennio, Marchesoni, A, Marzo Ortega, H, Porru, G, Moreta, Eg, Nash, P, Raffayova, H, Ranza, R, Raychaudhuri, Sp, Roussou, E, Scarpa, R, Song, Yw, Soriano, Er, Tak, Pp, Ujfalussy, I, de Vlam, K, Walsh, Ja |
| سنة النشر: | 2013 |
| المجموعة: | Università degli Studi del Molise: IRIS |
| مصطلحات موضوعية: | EMTREE medical terms: adult, arthriti, article, clinical assessment tool, Composite Psoriatic Arthritis Disease Activity Index, controlled study, DAS28, disease activity, Disease Activity for Psoriatic Arthriti, disease activity score, disease severity, female, human, intermethod comparison, major clinical study, male, priority journal, psoriasi, psoriatic arthriti, psoriatic arthritis disease activity score, scoring system |
| الوصف: | To develop new composite disease activity indices for psoriatic arthritis (PsA). METHODS: Data from routine clinic visits at multiple centres were collected in a systematic manner. Data included all domains identified as important in randomised controlled trials in PsA. Decisions to change treatment were used as surrogates for high disease activity. New indices were developed by multiple linear regression (psoriatic arthritis disease activity score: PASDAS) and empirically, utilising physician-defined cut-offs for disease activity (arithmetic mean of desirability functions: AMDF). These were compared with existing composite measures: Composite Psoriatic arthritis Disease Activity Index (CPDAI), Disease Activity for PSoriatic Arthritis (DAPSA), and Disease Activity Score for rheumatoid arthritis (DAS28). RESULTS: 161/503 (32%) subjects had treatment changes. Although all measures performed well, compared with existing indices, PASDAS was better able to discriminate between high and low disease activity (area under receiver operating curves (ROC)) curve with 95% CI: PASDAS 0.773 (0.723, 0.822); AMDF 0.730 (0.680, 0.780); CPDAI 0.719 (0.668, 0.770); DAPSA 0.710 (0.654, 0.766); DAS28 0.736 (0.680, 0.792). All measures were able to discriminate between disease activity states in patients with oligoarthritis, although area under the receiver operating curves (AUC) were generally smaller. In patients with severe skin disease (psoriasis area and severity index>10) both nonparametric and AUC curve statistics were nonsignificant for all measures. CONCLUSIONS: Two new composite measures to assess disease activity in PsA have been developed. Further testing in other datasets, including comparison with existing measures, is required to validate these instruments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/22798567; info:eu-repo/semantics/altIdentifier/wos/WOS:000318907100038; volume:72; issue:6; firstpage:986; lastpage:991; numberofpages:6; journal:ANNALS OF THE RHEUMATIC DISEASES; http://hdl.handle.net/11695/2775Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84877636515; http://www.ncbi.nlm.nih.gov/pubmed/22798567Test |
| DOI: | 10.1136/annrheumdis-2012-201341 |
| الإتاحة: | https://doi.org/10.1136/annrheumdis-2012-201341Test http://hdl.handle.net/11695/2775Test http://www.ncbi.nlm.nih.gov/pubmed/22798567Test |
| رقم الانضمام: | edsbas.5425D789 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/annrheumdis-2012-201341 |
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