المؤلفون: Peng-Peng Huang, A-Ying Liu, Feng Wang, Qi-Yu Xu, Yun Zhou, Quan-Bing Zhang, Fan Yang

المصدر: American journal of physical medicinerehabilitation. 100(7)

مصطلحات موضوعية: Extracorporeal Shockwave Therapy, Male, 030506 rehabilitation, medicine.medical_specialty, Contracture, Knee Joint, Physical Therapy, Sports Therapy and Rehabilitation, Ultrashort wave diathermy, Quadriceps Muscle, Transforming Growth Factor beta1, 03 medical and health sciences, Immobilization, 0302 clinical medicine, Muscular Diseases, Fibrosis, Diathermy, Medicine, Animals, Joint Contracture, Range of Motion, Articular, Fixation (histology), business.industry, Rehabilitation, Extracorporeal shock wave, medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Combined Modality Therapy, Surgery, Disease Models, Animal, Rabbits, medicine.symptom, 0305 other medical science, business, Range of motion, 030217 neurology & neurosurgery

الوصف: OBJECTIVE The purpose of this study was to examine the intervention effect of radial extracorporeal shock wave combined with ultrashort wave diathermy on immobilization-induced fibrosis and contracture of muscle. DESIGN The groups included male rabbits for the group (control group). To cause joint contracture, rabbits underwent plaster fixation of a left knee joint at full extension. After immobilization for 4 wks, all rabbits were randomly divided into five groups: model group, natural recovery group, radial extracorporeal shock wave treatment group, ultrashort wave diathermy group, and radial extracorporeal shock wave combined with ultrashort wave diathermy group. All intervention effects were assessed by evaluating the cross-sectional area and the collagen deposition of muscle, the knee joint range of motion and the protein levels for transforming growth factor β1 and hypoxia-inducible factor 1α. RESULTS The combined treatment group got the best recovery of the knee joint function. The combined treatment was more effective than radial extracorporeal shock wave or ultrashort wave diathermy alone against the fibrosis and contracture of muscle, as well as the overexpression of transforming growth factor β1 and hypoxia-inducible factor 1α. CONCLUSIONS Radial extracorporeal shock wave combined with ultrashort wave diathermy was effective in alleviating immobilization-induced contracture and fibrosis of muscle, as well as reducing the molecular manifestations of muscle fibrosis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642252b615867b7050db2fca3cef7b59Test
https://pubmed.ncbi.nlm.nih.gov/32969968Test

المؤلفون: Hua Zhang Zhong, Yun Zhou, Quan Bing Zhang, Yi Liu

المصدر: American Journal of Physical Medicine & Rehabilitation. 97:357-363

مصطلحات موضوعية: musculoskeletal diseases, medicine.medical_specialty, Contracture, Knee Joint, Physical Therapy, Sports Therapy and Rehabilitation, Ultrashort wave diathermy, Transforming Growth Factor beta1, 03 medical and health sciences, 0302 clinical medicine, Diathermy, Muscle Stretching Exercises, Joint capsule, medicine, Animals, Joint Contracture, Range of Motion, Articular, Joint (geology), 030222 orthopedics, business.industry, Rehabilitation, Fibrosis, Surgery, Disease Models, Animal, Treatment Outcome, medicine.anatomical_structure, Natural recovery, Rabbits, medicine.symptom, Range of motion, business, Joint Capsule, 030217 neurology & neurosurgery, Biomedical engineering

الوصف: Objective The aim of this study was to investigate the therapeutic effect of stretching combined with ultrashort wave on joint contracture and explore its possible mechanism. Design Thirty-two rabbits underwent unilateral immobilization of a knee joint at full extension to cause joint contracture. At 6 wks after immobilization, the rabbits were randomly divided into the following four groups: natural recovery group, stretching treatment group, ultrashort wave treatment group, and combined treatment group. For comparison, eight control group animals of corresponding age were also examined. The effect of stretching and ultrashort wave treatment on joint contracture was assessed by measuring the joint range of motion, evaluating the collagen deposition of joint capsule and assessing the mRNA and protein levels for transforming growth factor β1 in the joint capsule. Results The combined treatment group led to the best recovery of joint function. The combined treatment with stretching and ultrashort wave was more effective than stretching or ultrashort wave treatment alone against the synovial thickening of suprapatellar joint capsule, the collagen deposition of anterior joint capsule, and the elevated expression of transforming growth factor β1 in the joint capsule. Conclusions Stretching combined with ultrashort wave treatment was effective in improving joint range of motion, reducing the biomechanical, histological, and molecular manifestations of joint capsule fibrosis in a rabbit model of extending joint contracture.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efddbb84b46f615531e8f7abd5cfe98dTest
https://doi.org/10.1097/phm.0000000000000873Test

المؤلفون: Feng Wang, Quan-Bing Zhang, Qi-Yu Xu, Yun Zhou, A-Ying Liu

المصدر: Science Progress. 104:003685042110549

مصطلحات موضوعية: Myogenic differentiation, Contracture, Multidisciplinary, Knee Joint, business.industry, Ultrashort wave diathermy, MyoD, Muscle atrophy, Muscular Atrophy, Diathermy, Anesthesia, Rabbit model, Animals, Medicine, Rabbits, Range of Motion, Articular, medicine.symptom, Muscle, Skeletal, business, Range of motion, Joint immobilization

الوصف: The purpose of this study was to determine the preventive effect of ultrashort wave diathermy on immobilization-induced myogenic contracture and to explore its underlying mechanisms. Forty-two rabbits were randomly assigned into control (Group C), immobilization (Group I, which was further divided into one week, Group I-1; two weeks, Group I-2; and four weeks, Group I-4, subgroups by the length of immobilization) and ultrashort wave prevention (Group U, which was further divided into one week, Group U-1; two weeks, Group U-2; and four weeks, Group U-4, by time of treatment) groups. Intervention effects were assessed by evaluating rectus femoris cross-sectional area (CSA), knee range of motion, and the protein levels for myogenic differentiation (MyoD) and muscle atrophy F-box (MAFbx-1) in the rectus femoris. Compared with those of Group C, in Groups I and U, total contracture, myogenic contracture, MyoD and MAFbx-1 levels were significantly elevated, and CSA was significantly smaller ( p < 0.05). Compared with those of Group I at each time point, MyoD levels were significantly elevated, MAFbx-1 levels were significantly lower, CSA was significantly larger, and myogenic contracture was significantly alleviated in Group U ( p < 0.05). In the early stages of contracture, ultrashort wave diathermy reduces muscle atrophy and delays the process of myogenic contracture during joint immobilization; the mechanism of this may be explained as increased expression of MyoD triggered by suppression of the MAFbx-1-mediated ubiquitin-proteasome pathway.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd5f05a7055cfa88c7b630984894d21Test
https://doi.org/10.1177/00368504211054992Test

المؤلفون: Peng-Peng Huang¹, Quan-Bing Zhang¹, Yun Zhou¹, A-Ying Liu¹, Feng Wang², Qi-Yu Xu¹, Fan Yang¹

المصدر: American Journal of Physical Medicine & Rehabilitation. Jul2021, Vol. 100 Issue 7, p643-650. 8p.

مصطلحات موضوعية: *DIATHERMY, *COLLAGEN, *TRANSFORMING growth factors-beta, *CONTRACTURE (Pathology), *SKELETAL muscle, *RANGE of motion of joints, *ANIMAL experimentation, *CONVALESCENCE, *FIBROSIS, *RABBITS, *ANKYLOSIS, *ULTRASONIC therapy, *COMBINED modality therapy, *HYPOXEMIA

مستخلص: Objective: The purpose of this study was to examine the intervention effect of radial extracorporeal shock wave combined with ultrashort wave diathermy on immobilization-induced fibrosis and contracture of muscle. Design: The groups included male rabbits for the group (control group). To cause joint contracture, rabbits underwent plaster fixation of a left knee joint at full extension. After immobilization for 4 wks, all rabbits were randomly divided into five groups: model group, natural recovery group, radial extracorporeal shock wave treatment group, ultrashort wave diathermy group, and radial extracorporeal shock wave combined with ultrashort wave diathermy group. All intervention effects were assessed by evaluating the cross-sectional area and the collagen deposition of muscle, the knee joint range of motion and the protein levels for transforming growth factor β1 and hypoxia-inducible factor 1α. Results: The combined treatment group got the best recovery of the knee joint function. The combined treatment was more effective than radial extracorporeal shock wave or ultrashort wave diathermy alone against the fibrosis and contracture of muscle, as well as the overexpression of transforming growth factor β1 and hypoxia-inducible factor 1α. Conclusions: Radial extracorporeal shock wave combined with ultrashort wave diathermy was effective in alleviating immobilization- induced contracture and fibrosis of muscle, as well as reducing the molecular manifestations of muscle fibrosis. [ABSTRACT FROM AUTHOR]

المؤلفون: Quan Bing Zhang¹, Yun Zhou^1,2, Hua Zhang Zhong², Yi Liu¹

المصدر: American Journal of Physical Medicine & Rehabilitation. May2018, Vol. 97 Issue 5, p357-363. 7p.

مصطلحات موضوعية: *CONTRACTURE (Pathology), *PROTEIN metabolism, *RNA metabolism, *ANALYSIS of variance, *ANIMAL experimentation, *COLLAGEN, *CONVALESCENCE, *DIATHERMY, *HISTOLOGICAL techniques, *JOINTS (Anatomy), *RANGE of motion of joints, *KNEE, *POLYMERASE chain reaction, *PROBABILITY theory, *RABBITS, *STAINS & staining (Microscopy), *STATISTICS, *STRETCH (Physiology), *TRANSFORMING growth factors-beta, *DATA analysis, *REVERSE transcriptase polymerase chain reaction, *DESCRIPTIVE statistics, *IN vivo studies, *METABOLISM, *PREVENTION

مستخلص: Objective: The aim of this study was to investigate the therapeutic effect of stretching combined with ultrashort wave on joint contracture and explore its possible mechanism. Design: Thirty-two rabbits underwent unilateral immobilization of a knee joint at full extension to cause joint contracture. At 6 wks after immobilization, the rabbits were randomly divided into the following four groups: natural recovery group, stretching treatment group, ultrashort wave treatment group, and combined treatment group. For comparison, eight control group animals of corresponding age were also examined. The effect of stretching and ultrashort wave treatment on joint contracture was assessed by measuring the joint range of motion, evaluating the collagen deposition of joint capsule and assessing the mRNA and protein levels for transforming growth factor β1 in the joint capsule. Results: The combined treatment group led to the best recovery of joint function. The combined treatment with stretching and ultrashort wave was more effective than stretching or ultrashort wave treatment alone against the synovial thickening of suprapatellar joint capsule, the collagen deposition of anterior joint capsule, and the elevated expression of transforming growth factor β1 in the joint capsule. Conclusions: Stretching combined with ultrashort wave treatment was effective in improving joint range of motion, reducing the biomechanical, histological, and molecular manifestations of joint capsule fibrosis in a rabbit model of extending joint contracture. [ABSTRACT FROM AUTHOR]