التفاصيل البيبلوغرافية
| العنوان: |
Nocturnal hemodialysis does not improve overall measures of quality of life compared to conventional hemodialysis. |
| المؤلفون: |
Manns, Braden J.1 braden.manns@calgaryhealthregion.ca, Walsh, Michael W.1,2, Culleton, Bruce F.1,2, Hemmelgarn, Brenda1,2, Tonelli, Marcello1, Schorr, Melissa1, Klarenbach, Scott1 |
| المصدر: |
Kidney International. Mar2009, Vol. 75 Issue 5, p542-549. 8p. 1 Diagram, 3 Charts, 3 Graphs. |
| مصطلحات موضوعية: |
*HEMODIALYSIS, *QUALITY of life, *KIDNEY diseases, *THERAPEUTICS, *DIALYSIS (Chemistry) |
| مستخلص: |
We conducted a randomized controlled trial to compare the quality of life of 52 patients undergoing nocturnal hemodialysis and conventional hemodialysis. Quality of life was measured using a number of established methods including the Kidney Disease Quality of Life Short Form and the preference-based Euroqol EQ-5D questionnaire (whose scores varied from 0 to 1). The primary outcome was a change in the Euroqol EQ-5D index scores between baseline and 6 months. We performed additional analyses comparing change in quality of life from pre-randomization (when patients were unaware of treatment allocation) to 6 months. Other analyses considered the impact of nocturnal hemodialysis on four pre-selected Kidney Disease Quality of Life Short Form domains, and the longer term impact of nocturnal hemodialysis on quality of life. Compared with conventional hemodialysis, nocturnal hemodialysis increased Euroqol-EQ-5D index scores by 0.05, which was not significantly different from baseline. When six-month values were compared with pre-randomization values rather than baseline values, the between group difference was larger (0.12) though it was still not statistically significant (P=.06). Nocturnal hemodialysis was associated with clinically and statistically significant improvements in selected kidney-specific quality of life domains (P=.01 for effects of kidney disease; P=.02 for burden of kidney disease). Our primary quality of life analysis did not demonstrate a statistically significant change between nocturnal hemodialysis and conventional hemodialysis, though statistically significant and clinically important changes in some secondary kidney-disease- specific measures were observed.Kidney International (2009) 75, 542–549; doi:10.1038/ki.2008.639; published online 24 December 2008 [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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