التفاصيل البيبلوغرافية
| العنوان: |
Utility of a brief computerized battery to assess HIV-associated neurocognitive impairment in a resource-limited setting. |
| المؤلفون: |
Yechoor, Nirupama, Towe, Sheri, Robertson, Kevin1, Westreich, Daniel, Nakasujja, Noeline2, Meade, Christina christina.meade@duke.edu |
| المصدر: |
Journal of NeuroVirology. Dec2016, Vol. 22 Issue 6, p808-815. 8p. |
| مصطلحات موضوعية: |
*HIV infections, *NEUROBEHAVIORAL disorders, *DISEASE prevalence, *NEUROPSYCHOLOGICAL tests, *AIDS, *DIAGNOSIS |
| مستخلص: |
Despite the persistently high prevalence of neurocognitive impairment in HIV-positive patients, routine HIV care in many resource-limited settings does not include neuropsychological assessment. The objective of this study was to examine the utility of a brief computerized battery for identifying neurocognitive impairment in a busy HIV clinic in Uganda. Specifically, we compared performance on a gold standard neuropsychological exam to that on the CogState Brief Battery. In this cross-sectional study, 181 HIV-positive patients completed both assessment batteries in a randomized order. The primary outcome measures were neurocognitive impairment on the standard exam defined by the global deficit score and cumulative performance on the CogState Brief Battery. Sixty-nine participants (38 %) were classified as impaired on the standard neuropsychological exam, and participants who were classified as impaired performed significantly worse on CogState compared to those who were unimpaired ( p < 0.001). CogState had adequate specificity but low sensitivity, suggesting that it may not be a clinically useful screening tool to identify patients who likely have neurocognitive impairment in Uganda. This study supports the feasibility of using a computerized battery for assessing neurocognitive impairment in HIV-positive patients in resource-limited settings, but additional research is needed to identify screening tools with higher sensitivity for use in HIV clinics. [ABSTRACT FROM AUTHOR] |
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