التفاصيل البيبلوغرافية
| العنوان: |
Detection of interleukin-2 in addition to interferon-γ discriminates active tuberculosis patients, latently infected individuals, and controls. |
| المؤلفون: |
Biselli, R.1, Mariotti, S.2, Sargentini, V.2, Sauzullo, I.3, Lastilla, M.1, Mengoni, F.3, Vanini, V.4, Girardi, E.4, Goletti, D.4, D'Amelio, R.3,5, Nisini, R.2 roberto.nisini@iss.it |
| المصدر: |
Clinical Microbiology & Infection. Aug2010, Vol. 16 Issue 8, p1282-1284. 3p. |
| مصطلحات موضوعية: |
*TUBERCULOSIS, *INTERLEUKIN-2, *INTERFERONS, *MYCOBACTERIUM tuberculosis, *CYTOKINES |
| مستخلص: |
Clin Microbiol Infect 2010; 16: 1282–1284 Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-γ and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-γ distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB. [ABSTRACT FROM AUTHOR] |
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