دورية أكاديمية
Understanding Neurodegeneration from a Clinical and Therapeutic Perspective in Early Diabetic Retinopathy
| العنوان: | Understanding Neurodegeneration from a Clinical and Therapeutic Perspective in Early Diabetic Retinopathy |
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| المؤلفون: | Fragiotta S., Pinazo-Duran M. D., Scuderi G. |
| المساهمون: | Fragiotta, S., Pinazo-Duran, M. D., Scuderi, G. |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | aging, diabetic retinopathy, diet, neuroprotection, nutraceutic, supplementation, human, diabetes mellitu, neuroprotective agents |
| الوصف: | Recent evidence indicates that neurodegeneration is a critical element of diabetic retinopathy (DR) pathogenesis. The neuronal cells’ apoptosis contributes to microvascular impairment and blood–retinal barrier breakdown. Therefore, neurodegeneration represents an early intervention target to slow and prevent the development of microvascular alterations visible on clinical examination. Multimodal imaging features and functional assessment can permit the identification of neuronal damage in a subclinical stage before the recognition of DR signs. Clinical features of neurodegeneration are crucial in identifying patients at high risk of developing a vascular impairment and, thus, serve as outcome measures to understand the efficacy of supplementation. The optimal approach for targeting neurodegeneration contemplates the use of topical compounds that possibly act on different elements of the pathogenic cascade. To date, clinical trials available on humans tested three different topical agents, including brimonidine, somatostatin, and citicoline, with promising results. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35215442; info:eu-repo/semantics/altIdentifier/wos/WOS:000763052000001; volume:14; issue:4; firstpage:1; lastpage:14; numberofpages:14; journal:NUTRIENTS; http://hdl.handle.net/11573/1617285Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85124431610 |
| DOI: | 10.3390/nu14040792 |
| الإتاحة: | https://doi.org/10.3390/nu14040792Test http://hdl.handle.net/11573/1617285Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F559BDD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu14040792 |
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