التفاصيل البيبلوغرافية
| العنوان: |
RASSF8-mediated transport of Echinoid via the exocyst promotes Drosophila wing elongation and epithelial ordering. |
| المؤلفون: |
Eunice HY Chan (11641351), Yanxiang Zhou (8114279), Birgit L Aerne (9092831), Maxine V Holder (8319039), Anne Weston (2382226), David J Barry (8320179), Lucy Collinson (3507032), Nicolas Tapon (270959) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Model organisms, Imaging, Tumour Biology, Signalling & Oncogenes, Gene Expression, Genetics & Genomics, Developmental Biology, Cell Cycle & Chromosomes, Chemical Biology & High Throughput, Cell junctions, Development, Drosophila, Epithelium, Exocyst, Wing, Tapon FC001175, EM, LM, Gilbank, Terence, FLY-ack, Jordan, Peter, Maloney, Shaun, Earl, 06 Biological Sciences, 11 Medical and Health Sciences |
| الوصف: |
Cell-cell junctions are dynamic structures that maintain cell cohesion and shape in epithelial tissues. During development, junctions undergo extensive rearrangements to drive the epithelial remodelling required for morphogenesis. This is particularly evident during axis elongation, where neighbour exchanges, cell-cell rearrangements and oriented cell divisions lead to large-scale alterations in tissue shape. Polarised vesicle trafficking of junctional components by the exocyst complex has been proposed to promote junctional rearrangements during epithelial remodelling, but the receptors that allow exocyst docking to the target membranes remain poorly understood. Here, we show that the adherens junction component Ras Association domain family 8 (RASSF8) is required for the epithelial re-ordering that occurs during Drosophila pupal wing proximo-distal elongation. We identify the exocyst component Sec15 as a RASSF8 interactor. RASSF8 loss elicits cytoplasmic accumulation of Sec15 and Rab11-containing vesicles. These vesicles also contain the nectin-like homophilic adhesion molecule Echinoid, whose depletion phenocopies the wing elongation and epithelial packing defects observed in RASSF8 mutants. Thus, our results suggest that RASSF8 promotes exocyst-dependent docking of Echinoid-containing vesicles during morphogenesis. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/RASSF8-mediated_transport_of_Echinoid_via_the_exocyst_promotes_Drosophila_wing_elongation_and_epithelial_ordering_/16923250Test |
| DOI: |
10.25418/crick.16923250.v1 |
| الإتاحة: |
https://doi.org/10.25418/crick.16923250.v1Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.FE493A11 |
| قاعدة البيانات: |
BASE |
