دورية أكاديمية
Community-acquired bacterial meningitis in adults: in-hospital prognosis, long-term disability and determinants of outcome in a multicentre prospective cohort
| العنوان: | Community-acquired bacterial meningitis in adults: in-hospital prognosis, long-term disability and determinants of outcome in a multicentre prospective cohort |
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| المؤلفون: | Tubiana, S., Varon, E., Biron, C., Ploy, M.-C., Mourvillier, B., Taha, Muhamed-Kheir, Revest, M., Poyart, C., Martin-Blondel, Guillaume, Lecuit, M., Cua, E., Pasquet, B., Préau, M., Hoen, B., Duval, X. |
| المساهمون: | Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence des Pneumocoques (CNRP), Assistance Publique - Hôpitaux de Paris, Département des Maladies Infectieuses CHU Nantes, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), CHU Limoges, Centre Collaborateur de l'OMS pour les méningites bactériennes - WHO Collaborating Center Bacterial Meningitis (CC-OMS - WHO-CC), Institut Pasteur Paris (IP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Service des maladies infectieuses et réanimation médicale Rennes = Infectious Disease and Intensive Care Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre national de Référence des Streptocoques (CNR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service Maladies infectieuses et tropicales CHU Toulouse, Pôle Inflammation, infection, immunologie et loco-moteur CHU Toulouse (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Centre National de Référence Listeria - National Reference Center Listeria (CNRL), Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria (CC-OMS / WHO-CC), Service des Maladies infectieuses et tropicales CHU Necker, Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'infectiologie CHU Nice, Centre Hospitalier Universitaire de Nice (CHU Nice), AP-HP - Hôpital Bichat - Claude Bernard Paris, Groupe de Recherche en Psychologie Sociale (GRePS), Université Lumière - Lyon 2 (UL2), Service des Maladies Infectieuses et Tropicales CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), This work was supported by the Assistance Publique Hopitaux de Paris, French Ministry of Health, Inserm, SPILF, and the Pfizer Pharmaceutical company, which also funded ORP. The study was endorsed by the following professional organizations: Association Pour l'enseignement de la Thérapeutique, Société de Pathologie Infectieuse de Langue Française, Société Française de Microbiologie, Société Nationale Française de Médecine Interne, Société de Réanimation de Langue Française, Société Française de Gérontologie, Société Française d'Anesthésie-Réanimation., COMBAT study group : Principal investigator: DUVAL Xavier. Steering Committee: HOEN Bruno, MOURVILLIER Bruno, PLOY Marie-Cécile, TUBIANA Sarah, VARON Emmanuelle. Scientific committee: steering committee and the following members CARON François, BOLLAERT Pierre-Edouard, GAILLOT Olivier, TAHA Muhamed-Kheir, POYART Claire, BONACORSI Stephane, VANDENESCH François, CAMBAU Emmanuelle, LECUIT Marc, GRAVET Alain, FRACHET Bruno, De BROUCKER Thomas, LEVY BRUHL Daniel, RAFFI François. COMBAT Clinical Centres: ANGUEL Nadia, ARGAUD Laurent, ARISTA Sophie, ARMAND-LEFEVRE Laurence, BALAVOINE Stéphanie, BARADUC Régine, BARNAUD Guilène, BERAUD Guillaume, BERNARD Louis, BERNARS Georges, BERTEI Dominique, BESSEDE Emilie, BILLARD POMARES Typhaine, BIRON Charlotte, BLAND Stéphane, BOILEAU Julien, BOUBEAU Patrice, BOURDON Sandra, BOUSQUET Aurore, BOYER Sophie, BOZORG-GRAYELI Alexis, BRET Laurent, BRETONNIERE Cédric, BRICAIRE François, BROCAS Elsa, BRUN Michel, BURET Jennifer, BURUCOA Christophe, CABALION Jean, CABON Mathieu, CAMBAU Emmanuelle, CAMUSET Guillaume, CANEVET Christophe, CARON François, CARRICAJO Anne, CASTAN Bernard, CAUMES Eric, CAZANAVE Charles, CHABROL Amélie, CHALLAN-BELVAL Thibaut, CHANTEPERDRIX-MARILLIER Vanessa, CHAPLAIN Chantal, CHARLIER-WOERTHER Caroline, CHAUSSADE Hélène CHIROUZE Catherine, CLAIR Bernard, COLOT Julien, CONIL Jean-Marie, CORDEL Hugues, CORMIER Philippe, COUSSON Joël, CRONIER Pierrick, CUA Eric, DAO-DUBREMETZ Anne, DARGERE Sylvie, DEGAND Nicolas, DEKEYSER Sophie, DELAUNE Deborah, DENES Eric, DEQUIN Pierre-Francois, DESCAMPS Diane, DESCLOUX Elodie, DESMARETZ Jean-Luc, DIEHL Jean-Luc, DIMET Jérôme, DINH Aurélien, DUVAL Xavier, ESCAUT Lelia, FABE Claude, FAIBIS Frédéric, FLATEAU Clara, FONSALE Nathalie, FORESTIER Emmanuel, FORTINEAU Nicolas, GAGNEUX-BRUNON Amandine, GARANDEAU, GARCIA Magali, GAROT Denis, GAUDRY Stéphane, GOEHRINGER François, GRAVET Alain, GREGOIRE-FAUCHER Valérie, GROSSET Marine, GUBAVU Camélia, GUEIT Isabelle, GUELON Dominique, GUIMARD Thomas, GUINARD Jérôme, HADOU Tahar, HELENE Jean-Pierre, HENARD Sandrine, HENRY Benoit, HOCHART Anne-Cécile, HOEN Bruno, ILLES Gabriela, JAFFUEL Sylvain, JARRIN Irène, JAUREGUY Françoise, JOSEPH Cédric, JUVIN Marie-Emmanuelle, KAYAL Samer, LACASSIN Flore, LAMAURY Isabelle, LANOTTE Philippe, LAURENS Etienne, LAURICHESSE Henri, LE BRUN Cécile, LE MOING Vincent, LE TURNIER Paul, LECUYER Hervé, LEDRU Sylvie, LEGRIX Céline, LEMAIGNEN Adrien, LEMBLE Chantal, LEMEE Ludovic, LESENS Olivier, LEVAST Marion, LHOMMET Claire, MALES Silvija, MALPOTE Edith, MARTIN-BLONDEL Guillaume, MARX Matthieu, MASSON Raphael, MATRAY Olivier, MBADI Aurore, MECHAI Frédéric, MELLON Guillaume, MERENS Audrey, MEYOHAS Marie Caroline, MICHON Adrien, MOOTIEN YOGANADEN Joy, MORQUIN David, MOULY Stéphane, MROZEK Natacha, NGUYEN Sophie, NGUYEN Yohan, OGIELSKA Maja, OZIOL Eric, PAGE Bernard, PATRAT-DELON Solène, PATRY Isabelle, PECHINOT André, PICOT Sandrine, PIERREJEAN, PIROTH Lionel, PLASSART Claire, PLESSIS Patrice, PLOY Marie-Cécile, PORTEL Laurent, POUBEAU Patrice, POUPARD Marie, POYART Claire, PRAZUCK Thierry, QUAESAET Luc, RAFFI François, RAMANANTSOA Adriatsiferana, RAPP Christophe, RASKINE Laurent, RAYMOND Josette, REVEST Matthieu, RICHE Agnès, ROBADAY-VOISIN Stéphanie, ROBIN Frédéric, ROMASZKO JP, ROUSSEAU Florence, ROUX Anne-Laure, ROYER Cecile, SAADA Matthieu, SALMON Dominique, SAROUFIM Carlo, SCHMIT Jean Luc, SEBIRE Manuela, SEGONDS Christine, SIVADON-TARDY Valérie, SOISMIER Nathalie, Solen KERNEIS, SON Olivia, SUNDER Simon, SUY Florence, TANDE Didier, TANKOVIC Jacques, VALIN Nadia, VAN GRUNDERBEECK Nicolas, VANDENESCH François, VARON Emmanuelle, VERDON Renaud, VERGNAUD Michel, VERNET-GARNIER Véronique, VIDAL Magali, VITRAT Virginie, VITTECOQ Daniel, VUOTTO Fanny. Coordination and statistical analyses (Clinical trial unit, Hôpitaux Universitaires Paris Nord Val de Seine, AP-HP, Paris): GORENNE Isabelle, LAOUENAN Cédric, MARCAULT Estelle, MENTRE France, PASQUET Blandine, ROY Carine, TUBIANA Sarah. Scientific partnership: SPLIF, CMIT, SRLF, SFM, REIVAC, SFORL, APNET, SPF. Partners: ORP (MC PLOY), GPIP/ACTIV (Corinne Levy). |
| المصدر: | ISSN: 1198-743X. |
| بيانات النشر: | HAL CCSD Elsevier for the European Society of Clinical Microbiology and Infectious Diseases |
| سنة النشر: | 2020 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | Bacterial, Community-acquired, Determinants, Long-term outcome, Prognosis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| الوصف: | International audience ; Objectives - To identify factors associated with unfavourable in-hospital outcome (death or disability) in adults with community-acquired bacterial meningitis (CABM). Methods - In a prospective multicentre cohort study (COMBAT; February 2013 to July 2015), all consecutive cases of CABM in the 69 participating centres in France were enrolled and followed up for 12 months. Factors associated with unfavourable outcome were identified by logistic regression and long-term disability was analysed. Results - Among the 533 individuals enrolled, (Streptococcus pneumoniae 53.8% (280/520 isolates identified), Neisseria meningitidis 21.3% (111/520), others 24.9% (129/520)), case fatality rate was 16.9% (90/533) and unfavourable outcome occurred in 45.0% (225/500). Factors independently associated with unfavourable outcome were: age >70 years (adjusted odds ratio (aOR) 4.64; 95% CI 1.93-11.15), male gender (aOR 2.11; 95% CI 1.25-3.57), chronic renal failure (aOR 6.65; 95% CI 1.57-28.12), purpura fulminans (aOR 4.37; 95% CI 1.38-13.81), localized neurological signs (aOR 3.72; 95% CI 2.29-6.05), disseminated intravascular coagulation (aOR 3.19; 95% CI 1.16-8.79), cerebrospinal fluid (CSF) white-cell count <1500 cells/μL (aOR 2.40; 95% CI 1.42-4.03), CSF glucose concentration (0.1-2.5 g/L: aOR 1.92; 95% CI 1.01-3.67; <0.1 g/L: aOR 2.24; 95% CI 1.01-4.97), elevated CSF protein concentration (aOR 1.09; 95% CI 1.03-1.17), time interval between hospitalization and lumbar puncture >1 day (aOR 2.94; 95% CI 1.32-6.54), and S. pneumoniae meningitis (aOR 4.99; 95% CI 1.98-12.56), or meningitis other than N. meningitidis (aOR 4.54; 95% CI 1.68-12.27). At 12 months, 26.7% (74/277) had hearing loss, 32.8% (87/265) depressive symptoms, 31.0% (86/277) persistent headache, and 53.4% had a physical health-related quality of life (142/266) <25th centile of the distribution of the score in the general French population (p < 0.0001). Conclusions - The burden of CABM (death, disability, depression, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31927117; pasteur-02618662; https://pasteur.hal.science/pasteur-02618662Test; https://pasteur.hal.science/pasteur-02618662/documentTest; https://pasteur.hal.science/pasteur-02618662/file/S1198743X19306792.pdfTest; PII: S1198-743X(19)30679-2; PUBMED: 31927117 |
| DOI: | 10.1016/j.cmi.2019.12.020 |
| الإتاحة: | https://doi.org/10.1016/j.cmi.2019.12.020Test https://pasteur.hal.science/pasteur-02618662Test https://pasteur.hal.science/pasteur-02618662/documentTest https://pasteur.hal.science/pasteur-02618662/file/S1198743X19306792.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.714A78A0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cmi.2019.12.020 |
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