Concomitant Radiation Recall Dermatitis and Organizing Pneumonia following Breast Radiotherapy: A Case Report
| العنوان: | Concomitant Radiation Recall Dermatitis and Organizing Pneumonia following Breast Radiotherapy: A Case Report |
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| المؤلفون: | Julie A. Bradley, Fantine Giap, Lisa Spiguel, Karen Daily, Paul Okunieff, R.B. Mailhot-Vega, Nancy P. Mendenhall, Natalie A. Lockney, I-Chia Liu, Li Lu, Michael A. Jantz |
| المصدر: | Case Reports in Oncology Case Reports in Oncology, Vol 13, Iss 2, Pp 875-882 (2020) |
| بيانات النشر: | S. Karger AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Sentinel lymph node, Case Report, Dermatitis, lcsh:RC254-282, Radiation toxicity, 03 medical and health sciences, 0302 clinical medicine, Biopsy, medicine, medicine.diagnostic_test, business.industry, Radiation recall, Segmental Mastectomy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Dermatology, Radiation therapy, Radiation-induced organizing pneumonia, 030104 developmental biology, Radiation Recall Dermatitis, Oncology, 030220 oncology & carcinogenesis, Concomitant, Etiology, Complication, business |
| الوصف: | Purpose: Radiation recall dermatitis (RRD) is a rare complication that occurs after completion of radiation therapy (RT) and initiation of a precipitating agent, most commonly chemotherapeutic medications. Various theories attempt to explain the mechanism, including activation of the body’s inflammatory pathways through nonimmune activation. Likewise, radiation-induced organizing pneumonia (RIOP) is an infrequent but potentially life-threatening complication of RT that, while not fully understood, is suspected to be partly an autoimmune reaction. Patient: We present the case of a 71-year-old female with a history of type 2 diabetes mellitus, hypothyroidism, interstitial cystitis, and osteoarthritis who presented with clinical stage T1N0M0 ER+/PR–/HER2– invasive ductal carcinoma of the lower outer quadrant of the left breast, for which she underwent left segmental mastectomy and sentinel lymph node biopsy followed by completion axillary lymph node dissection. Her final pathologic stage was T1N1M0. Result: The patient developed RRD and later RIOP following receipt of radiation and chemotherapy, which resolved with steroid administration. Conclusions: The rarity of both RRD and RIOP occurring in a patient, as in our case, suggests a shared pathophysiology behind these two complications. As both reactions involve some degree of inflammation and respond to corticosteroids, it seems likely that the etiologies of RRD and RIOP lie within the inflammatory pathway. However, further investigation should evaluate the frequency, duration, and triggering of concomitant RRD and RIOP. |
| تدمد: | 1662-6575 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8bfeef27336197d27a18c4a1bc7d03Test https://doi.org/10.1159/000508493Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b8bfeef27336197d27a18c4a1bc7d03 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16626575 |
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