المؤلفون: James C Y Leong, Helen L. Long, Kelvin Ngan

المصدر: Indian Journal of Ophthalmology, Vol 68, Iss 9, Pp 2004-2006 (2020)
Indian Journal of Ophthalmology

مصطلحات موضوعية: medicine.medical_specialty, medicine.diagnostic_test, Retinal vasculitis, business.industry, Sweet Syndrome, Panuveitis, panuveitis, acute febrile neutrophilic dermatosis, Case Reports, medicine.disease, sweet syndrome, Rash, Dermatology, Intraocular inflammation, Ophthalmology, Intravenous cyclophosphamide, lcsh:Ophthalmology, lcsh:RE1-994, retinal vasculitis, Skin biopsy, medicine, uveitis, medicine.symptom, business, Uveitis

الوصف: Ocular manifestations of Sweet syndrome, or acute febrile neutrophilic dermatosis, are usually limited to the anterior segment. We report the case of a patient with bilateral panuveitis and retinal vasculitis associated with Sweet syndrome. A 45-year-old Asian female with an undiagnosed febrile illness with rash presented with bilateral panuveitis with haemorrhagic occlusive retinal vasculitis. Skin biopsy confirmed Sweet Syndrome. Intraocular inflammation resolved with a combination of topical and systemic corticosteroids as well as intravenous cyclophosphamide, with resulting permanent severe right visual impairment. Although an uncommon condition, Sweet syndrome should be considered in any febrile patient with skin lesions and uveitis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3eac4d3cfb14a06921736c3cd16018Test
http://www.ijo.in/article.asp?issn=0301-4738;year=2020;volume=68;issue=9;spage=2004;epage=2006;aulast=NganTest

المؤلفون: Yoshio Suzuki, Shin-Ichiro Kagami, Yohei Nomoto, Kensuke Suga, Akiko Sudo, Jun Isogai

المصدر: Modern rheumatology case reports. 4(1)

مصطلحات موضوعية: Male, medicine.medical_specialty, Optic Neuritis, business.industry, Osteomyelitis, Prednisolone, Granulomatosis with Polyangiitis, macromolecular substances, Middle Aged, medicine.disease, Dermatology, Magnetic Resonance Imaging, Intravenous cyclophosphamide, Treatment Outcome, stomatognathic system, Refractory, Maxilla, Medicine, Humans, Optic neuritis, business, Granulomatosis with polyangiitis, Cyclophosphamide

الوصف: We report a case of a 61-year-old man with granulomatosis with polyangiitis (GPA) complicated with refractory optic neuritis and maxillary osteomyelitis. He had been treated with prednisolone (PSL) as cryptogenic organizing pneumonia in the respiratory department for 2 years. Afterward, he complained tenderness of paranasal sinuses and rapidly progressive visual loss of the left eye. Although both MPO-ANCA and PR3-ANCA were negative, he was diagnosed as GPA based on the American College of Rheumatology 1990 criteria. Ophthalmologic and oral examination revealed left optic neuritis and destructive maxillary bone. Magnetic resonance imaging (MRI) showed the optic neuritis and inflammation around the optic nerve. This finding suggested that the direct spread of inflammation from paranasal sinuses caused the optic neuritis. In a short time, increasing a dose of PSL and administration of intravenous cyclophosphamide were initiated. Antibiotics were also administered to treat sinusitis. Although his visual acuity of the left eye deteriorated to no light perception temporarily, it finally improved after treatment and findings of MRI were also improved. In contrast, destruction of maxilla bone had been progressing. This is a rare case of GPA complicated with optic neuritis due to sinusitis and maxillary osteomyelitis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcdcd53cb64820d2687b56925f3e40bTest
https://pubmed.ncbi.nlm.nih.gov/33086959Test

المؤلفون: Sayan Basu, Pragnya R. Donthineni, Swapna S Shanbhag, Anahita Kate

المصدر: F1000Research

مصطلحات موضوعية: medicine.medical_specialty, genetic structures, medicine.medical_treatment, Cicatrizing conjunctivitis, conjunctival granuloma, Disease, General Biochemistry, Genetics and Molecular Biology, Intravenous cyclophosphamide, Punctate keratitis, Medicine, autoimmune blistering disorders, Lost to follow-up, Clinical Practice Article, General Pharmacology, Toxicology and Pharmaceutics, skin and connective tissue diseases, integumentary system, General Immunology and Microbiology, business.industry, Bullous pemphigoid, case series, Immunosuppression, Articles, General Medicine, medicine.disease, Dermatology, eye diseases, sense organs, CONJUNCTIVAL SCARRING, cicatrizing conjunctivitis, business

الوصف: Ocular involvement in cases of bullous pemphigoid is rare and when present, the signs are usually subtle and in the form of fine tarsal scarring and dry eye disease. The current report aims to describe the clinical features and management protocols in a series of cases with aggressive ocular manifestations at presentation. All cases of bullous pemphigoid seen between 2017 and 2020 were included in this retrospective case series. Data regarding the clinical features, treatment administered, and outcomes was collected. Five cases (n=10 eyes) of bullous pemphigoid disease with ocular involvement were included. All eyes had significant cicatricial conjunctival changes in the form of symblephara, inferior forniceal shortening, and tarsal conjunctival scarring. Conjunctival granulomas were present in 3/10 eyes. Corneal involvement in the form of punctate keratitis was present in all eyes while 4/10 eyes had an epithelial defect as well. The management of these cases involved topical therapy with corticosteroids and lubricants (n=10 eyes) while pulse doses of intravenous methyl prednisolone were administered in 5/5 cases. Pulse intravenous cyclophosphamide was supplemented in 2/5 cases. Adequate control of the disease was noted in 3/5 cases while one case had a recalcitrant form of the disease and developed a dermalised ocular surface in both eyes. The last patient was lost to follow up during the course of therapy. Bullous pemphigoid can present with an aggressive form of cicatrizing conjunctivitis similar to other variants of autoimmune blistering disorders and must be considered as a differential in cases presenting with ocular cicatricial disease. Long-term intensive immunosuppression is required for the management of these cases to preserve the visual function and the integrity of the globe.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2da465b019e6db485b7fbea82abb676Test
https://doi.org/10.12688/f1000research.75120.2Test

المؤلفون: Ioannis Antonopoulos, Stamatis-Nick C. Liossis

المصدر: Mediterranean Journal of Rheumatology
Mediterranean Journal of Rheumatology, Vol 29, Iss 4, Pp 221-223 (2018)

مصطلحات موضوعية: Vasculitis, medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, biology, business.industry, Case Report, Dermatomyositis, medicine.disease, Dermatology, Disease control, Intravenous cyclophosphamide, Rheumatology, Refractory, medicine, biology.protein, Intravenous Immunoglobulin, Rituximab, lcsh:RC925-935, Antibody, business, medicine.drug, Inflammatory disorder

الوصف: Dermatomyositis is an idiopathic inflammatory disorder of the muscles associated with characteristic cutaneous findings. Herein we report a 68-year old woman who presented with dermatomyositis associated with painful vasculitic lesions on both hands, refractory to conventional treatment. Steroids, topical tacrolimus, antimalarials and intravenous cyclophosphamide were tried with no beneficial effect. Rituximab was also administered with no initial effect; soon afterwards, intravenous immunoglobulin was administered with good results. Some cases of cutaneous dermatomyositis may require trials of different therapies to identify the treatment regimen that produces satisfactory disease control.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92324fe6e01abeff012b4cea965ffd3Test
https://doi.org/10.31138/mjr.29.4.221Test

المؤلفون: Takamitsu Makino, Hironobu Ihn, Masatoshi Jinnin, Katsunari Makino, Satoshi Fukushima, Kei Yamauchi

المصدر: Nishi Nihon Hifuka. 78:356-361

مصطلحات موضوعية: 030203 arthritis & rheumatology, medicine.medical_specialty, business.industry, Pulse therapy, Interstitial lung disease, Azathioprine, Dermatology, Pharmacology, medicine.disease, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Intravenous cyclophosphamide, Internal medicine, Medicine, 030212 general & internal medicine, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::70dfda895df0aed3cb8b109ec23109adTest
https://doi.org/10.2336/nishinihonhifu.78.356Test

المؤلفون: Tatsuro Okano, Tamihiro Kawakami, Sora Takeuchi, Satoko Kimura, Yoshinao Soma

المصدر: International Journal of Dermatology. 54:e323-e325

مصطلحات موضوعية: medicine.medical_specialty, Intravenous cyclophosphamide, Refractory, business.industry, Pulse therapy, medicine, Dermatology, Arteritis, Radiology, medicine.disease, business, Complete resolution

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::39287b564b74402c8b671a53f6019d4aTest
https://doi.org/10.1111/ijd.12863Test

المؤلفون: Pornsak Dissaneewate, Edward McNeil, Prayong Vachvanichsanong

المصدر: International Urology and Nephrology

مصطلحات موضوعية: Male, Nephrology, medicine.medical_specialty, Adolescent, Cyclophosphamide, Prednisolone, Urology, SLE, Anti-Inflammatory Agents, Lupus nephritis, Kaplan-Meier Estimate, Methylprednisolone, Severity of Illness Index, Systemic lupus erythematosus, Recurrence, Internal medicine, Severity of illness, medicine, Nephrology - Original Paper, IVCY, Humans, Child, Survival rate, Retrospective Studies, Proteinuria, business.industry, Intravenous cyclophosphamide, medicine.disease, Lupus Nephritis, Dermatology, Survival Rate, Treatment Outcome, Child, Preschool, Creatinine, Immunology, Administration, Intravenous, Drug Therapy, Combination, Female, medicine.symptom, business, Immunosuppressive Agents, medicine.drug

الوصف: Background Intravenous cyclophosphamide (IVCY) has been used to treat severe lupus nephritis (LN) for many years. Because of the wide variety of manifestations of the condition and the long-term nature of the disease, outcomes vary widely. Objective To evaluate and compare the immediate and long-term results of IVCY in pediatric onset severe LN and between patients with normal and abnormal initial renal function. Methods Patients aged

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1d469ae2abc0d2988d07d066d49d47Test
https://doi.org/10.1007/s11255-012-0331-9Test

المؤلفون: C. L. Teh, Ahmad Tirmizi Jobli, Sharifah Aishah Wan

المصدر: Lupus. 25(13)

مصطلحات موضوعية: Adult, Pathology, medicine.medical_specialty, Cyclophosphamide, Adolescent, 030204 cardiovascular system & hematology, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Intravenous cyclophosphamide, Fatal Outcome, Rheumatology, medicine, Humans, Lupus Erythematosus, Systemic, Young adult, Single institution, Retrospective Studies, 030203 arthritis & rheumatology, Lupus pneumonitis, business.industry, Immunoglobulins, Intravenous, Retrospective cohort study, Pneumonia, medicine.disease, Dermatology, Female, Radiography, Thoracic, Steroids, Presentation (obstetrics), business, medicine.drug

الوصف: Objective The aim of this study was to examine the clinical features, treatment and outcome of systemic lupus erythematosus (SLE) patients in our centre who presented with lupus pneumonitis as the initial manifestation. Methods We performed a retrospective review of all patients who presented with lupus pneumonitis during the initial SLE manifestation from March 2006 to March 2015. Results There were a total of five patients in our study who presented with fever and cough as the main clinical features. All patients had pulmonary infiltrates on chest radiographs. High-resolution computed tomography, which was performed in two patients, showed ground glass opacities with patchy consolidations bilaterally. All patients received high-dose steroids, 80% received intravenous cyclophosphamide and 60% received intravenous immunoglobulin. Two patients died from severe lupus pneumonitis within 2 weeks of admission despite treatment with ventilation, steroids, cyclophosphamide and intravenous immunoglobulin. Conclusions Acute lupus pneumonitis is an uncommon presentation of SLE. Mortality in this case series is 40%.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caf534a8048e9024b5d88142aaeddeeTest
https://pubmed.ncbi.nlm.nih.gov/27125293Test

المؤلفون: Pichaporn Artornsombudh, John H. Kempen

المصدر: Uveitis: An Update ISBN: 9788132222941

مصطلحات موضوعية: medicine.medical_specialty, genetic structures, business.industry, Legal blindness, Inflammation, medicine.disease, Dermatology, eye diseases, Intravenous cyclophosphamide, Chronic disease, medicine, medicine.symptom, business, Ocular inflammation, Uveitis

الوصف: Inadequately controlled uveitis is a leading cause of permanent visual loss, accounting for 5–20 % of cases of legal blindness [1–4]. Ocular inflammation is the principal cause of complications and morbidities. Delayed or inadequate control of inflammation can lead to serious sequelae resulting in visual impairment [5–8]. Therefore, the primary goal of management is to control the inflammation. There are two phases of treatment of ocular inflammation. First is induction of control of inflammation, the goal of which is to suppress the sight-threatening ocular inflammation as soon as possible with a rapidly effective medication, usually using topical, systemic, and/or injected corticosteroids. For remitting forms of uveitis, this may be the only treatment necessary. For chronic disease requiring suppressive therapy, the second aim is maintenance of control of inflammation after successful treatment in order to prevent recurrence or relapse of the ocular inflammation. Immunosuppressives have their primary role in maintenance of control of inflammation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2a39117bc1bc05689ac892416048c715Test
https://doi.org/10.1007/978-81-322-2295-8_9Test

المؤلفون: Takashi Taniguchi, Mizuho Yamamoto, Tomonori Takekoshi, Shinichi Sato, Ryo Sunaga, Yohei Ichimura, Hiroshi Mitsui, Takamoto Ohse, Makoto Sugaya, Zenshiro Tamaki, Yoshihide Asano, Takehiro Takahashi

المصدر: The Journal of Dermatology. 41:533-535

مصطلحات موضوعية: medicine.medical_specialty, Pathology, Cyclophosphamide, medicine.medical_treatment, Scleroderma Renal Crisis, Pulse therapy, Dermatology, Gastroenterology, Intravenous cyclophosphamide, Renal Dialysis, Internal medicine, medicine, Humans, In patient, Scleroderma, Systemic, Pulse (signal processing), business.industry, Interstitial lung disease, General Medicine, Middle Aged, medicine.disease, Antirheumatic Agents, Kidney Failure, Chronic, Female, Hemodialysis, Lung Diseases, Interstitial, business, medicine.drug

الوصف: Interstitial lung disease and scleroderma renal crisis are major complications of systemic sclerosis, which occasionally coexist in patients with the diffuse cutaneous subtype. We herein report a case of diffuse cutaneous systemic sclerosis under hemodialysis due to a previous history of scleroderma renal crisis, whose interstitial lung disease was effectively and safely treated with a half dose of i.v. cyclophosphamide pulse. The dose of cyclophosphamide and the timing of hemodialysis leading to efficacy and low toxicity are discussed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e60cb17feacaee90283d13c620f65aTest
https://doi.org/10.1111/1346-8138.12495Test