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المؤلفون: Jane E. Ishmael, Juho Kellosalo, Anja O. Paatero, Shinya Oishi, Soheila Kazemi, Jeffrey D. Serrill, Uwe Richter, Shinsaku Kawaguchi, Ville O. Paavilainen, Daphne R. Mattos, Christopher C. Thornburg, Walter K. Vogel, Xuemei Wan, Dale Tranter, Kerry L. McPhail
المساهمون: Institute of Biotechnology, Molecular and Integrative Biosciences Research Programme
المصدر: ACS Chemical Biology
مصطلحات موضوعية: 0301 basic medicine, Sec61, Mutant, CYCLODEPSIPEPTIDE, Photoaffinity Labels, 01 natural sciences, Biochemistry, 03 medical and health sciences, Depsipeptides, MYCOLACTONE, MARINE CYANOBACTERIA, Humans, Binding site, BIOLOGICAL EVALUATION, Cytotoxicity, Cells, Cultured, Binding Sites, PROPOSED STRUCTURE, 010405 organic chemistry, Chemistry, POTENT, Membrane Proteins, INHIBITOR, General Medicine, Articles, DEPSIPEPTIDE, Translocon, 3. Good health, 0104 chemical sciences, Cell biology, TRANSLOCATION, 030104 developmental biology, Membrane protein, Molecular Medicine, 1182 Biochemistry, cell and molecular biology, Pharmacophore, APRATOXIN, Biogenesis, SEC Translocation Channels
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fca17dd4f6b29f56e39ec7d5d1c5124Test
http://hdl.handle.net/10138/319505Test -
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المؤلفون: Xuemei Wan, Lamiaa A. Shaala, Josep Saurí, Jane E. Ishmael, R. Thomas Williamson, Ryan D. Cohen, Kerry L. McPhail, Gary E. Martin, David A. Gallegos, Diaa T. A. Youssef, Benjamin Philmus, Alec O. Vallota-Eastman, Aleksandra E. Sikora, Patrick Videau
المصدر: J Nat Prod
مصطلحات موضوعية: Glyceric acid, Magnetic Resonance Spectroscopy, Stereochemistry, medicine.medical_treatment, Pharmaceutical Science, Cyanobacteria, 01 natural sciences, Article, Analytical Chemistry, HeLa, chemistry.chemical_compound, Cell Line, Tumor, Depsipeptides, Drug Discovery, medicine, Chymotrypsin, Humans, Protease Inhibitors, Indian Ocean, Chromatography, High Pressure Liquid, Piperidones, Pharmacology, Serine protease, Depsipeptide, Protease, biology, 010405 organic chemistry, Organic Chemistry, Nuclear magnetic resonance spectroscopy, Trypsin, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, biology.protein, Molecular Medicine, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ef0073a37367b83f2c08411bb7c88bTest
https://doi.org/10.1021/acs.jnatprod.8b00117Test -
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المؤلفون: Jeffrey D. Serrill, Dong Li, Rebecca A. Medina, Patrick Videau, William H. Gerwick, Edward A. Mitchell, Oliver B. Vining, Philip Proteau, Jane X. Kelly, Jane E. Ishmael, Kerry L. McPhail
المصدر: Journal of Natural Products
مصطلحات موضوعية: Stereochemistry, Panama, Pharmaceutical Science, Antineoplastic Agents, Biology, 010402 general chemistry, Mass spectrometry, medicine.disease_cause, Cyanobacteria, 01 natural sciences, Article, Analytical Chemistry, Depsipeptides, Drug Discovery, medicine, Humans, Nuclear Magnetic Resonance, Biomolecular, Chromatography, High Pressure Liquid, Pharmacology, Depsipeptide, Hplc analysis, Molecular Structure, 010405 organic chemistry, Toxin, Organic Chemistry, Absolute configuration, Nuclear magnetic resonance spectroscopy, In vitro, 0104 chemical sciences, 3. Good health, Complementary and alternative medicine, Molecular Medicine, Drug Screening Assays, Antitumor, Human cancer
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922003c90493acf618ecde024c409992Test
http://europepmc.org/articles/PMC4380200Test -
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المؤلفون: Kerry L. McPhail, Elise S. Cowley, Jane E. Ishmael, Lamiaa A. Shaala, Christopher C. Thornburg, Diaa T. A. Youssef, Justyna Sikorska
المصدر: Journal of Natural Products. 76:1781-1788
مصطلحات موضوعية: Cyanobacteria, Stereochemistry, Pharmaceutical Science, Marine Biology, Article, Analytical Chemistry, Inhibitory Concentration 50, Lactones, chemistry.chemical_compound, Depsipeptides, Safrole, Drug Discovery, Humans, Proline, Indian Ocean, Lyngbya Toxins, Pipecolic acid, Moorea producens, Pharmacology, chemistry.chemical_classification, Depsipeptide, Molecular Structure, biology, Cytotoxins, Organic Chemistry, Absolute configuration, Sulfoxide, biology.organism_classification, Amino acid, Thiazoles, Complementary and alternative medicine, chemistry, Pipecolic Acids, Molecular Medicine, Drug Screening Assays, Antitumor, Oxidation-Reduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f911fe69f9ee2b10fd62ccfd957b8079Test
https://doi.org/10.1021/np4004992Test -
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المؤلفون: Andrew M. Hau, Kerry L. McPhail, Jeffrey D. Serrill, Arup K. Indra, Hyo Sang Jang, Xuemei Wan, Daniel J. Coleman, Jane E. Ishmael, Adam W.G. Alani
المصدر: Investigational new drugs. 34(1)
مصطلحات موضوعية: 0301 basic medicine, Vascular Endothelial Growth Factor A, Cell, Mice, Nude, Antineoplastic Agents, Breast Neoplasms, Bioinformatics, 03 medical and health sciences, Mice, Nude mouse, Cell Movement, Cell Line, Tumor, Depsipeptides, medicine, Human Umbilical Vein Endothelial Cells, Animals, Humans, Pharmacology (medical), Cell Proliferation, Pharmacology, Depsipeptide, biology, Cell growth, Kinase insert domain receptor, biology.organism_classification, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Vascular endothelial growth factor A, 030104 developmental biology, medicine.anatomical_structure, Oncology, Mechanism of action, Cancer research, Female, medicine.symptom, Glioblastoma, G1 phase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f64ccf8184994a578dddf0d04af353cTest
https://pubmed.ncbi.nlm.nih.gov/26563191Test -
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المؤلفون: Nobutaka Fujii, Hiroaki Ohno, Ryota Nabika, Shinya Oishi, Jane E. Ishmael, Takashi L. Suyama, Kerry L. McPhail, Andrew M. Hau, Ryosuke Misu
المصدر: Bioorganicmedicinal chemistry letters. 25(2)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, N-Methylamino acid, Pharmaceutical Science, Peptide, Antineoplastic Agents, Cleavage (embryo), Biochemistry, Article, Coibamide A, chemistry.chemical_compound, Structure-Activity Relationship, Depsipeptides, Neoplasms, Drug Discovery, Peptide synthesis, Tumor Cells, Cultured, HATU, Humans, Molecular Biology, Peptide sequence, Depsipeptide, Solid-Phase Synthesis Techniques, Biological evaluation, Cell Proliferation, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Stereoisomerism, Antiproliferative peptide, chemistry, Molecular Medicine, Epimer
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcf98fefd0bd29056ba6c9dd236f20fTest
https://pubmed.ncbi.nlm.nih.gov/25488840Test