التفاصيل البيبلوغرافية
| العنوان: |
Lifetime history of major depressive disorder is associated with decreased reward learning: Evidence from a novel online version of the probabilistic reward task. |
| المؤلفون: |
Esfand, Shiba M.1 (AUTHOR), Null, Kaylee E.1 (AUTHOR), Duda, Jessica M.1 (AUTHOR), de Leeuw, Josh2 (AUTHOR), Pizzagalli, Diego A.1,3,4 (AUTHOR) dap@mclean.harvard.edu |
| المصدر: |
Journal of Affective Disorders. Apr2024, Vol. 350, p1007-1015. 9p. |
| مصطلحات موضوعية: |
*REWARD (Psychology), *MENTAL depression, *DEPRESSION in women, *PSYCHOMETRICS, *SIGNAL detection |
| مستخلص: |
The Probabilistic Reward Task (PRT) is a signal detection task that assesses reward learning. In laboratory versions of the task, individuals with current or past major depressive disorder (MDD) were characterized by reduced response bias towards a more frequently rewarded stimuli, compared to controls. Our main goal was to develop and validate a novel online version of the PRT, and, in exploratory analyses, evaluate whether lifetime history of depression was associated with blunted reward learning. 429 participants recruited via CloudResearch completed questionnaires assessing psychiatric history and an online PRT featuring visually appealing stimuli. 108 participants reported either current or past diagnosis of MDD (lifetime MDD group), and were compared to 321 without lifetime MDD. Participants showed overall increase in response bias, validating the online PRT. Females with lifetime MDD (N = 43), compared to females without prior history of MDD (N = 173), exhibited blunted response bias towards the more frequently rewarded stimulus (i.e., reduced reward learning). Participants did not undergo a structured clinical interview, thus we cannot confirm whether they met full diagnostic criteria for depression. The online PRT yielded similar psychometric properties as laboratory versions of the task. In exploratory analyses, females with lifetime MDD showed a lower propensity to modulate behavior as a function of rewards, which might contribute to heightened vulnerability for developing MDD in females. Future studies should consider social, cultural, and neurobiological factors contributing to sex differences in reward responsiveness and how factors may relate to disease prognosis and treatment outcomes. • A novel probabilistic reward task was developed and validated in an online sample. • Females with lifetime depression exhibited blunted reward learning. • Blunted reward learning might contribute to higher vulnerability to MDD in women. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
