المؤلفون: Seo-Hyun Cho, Ju-Yeon Lee, Honey Kim, Sung-Wan Kim, Jae-Min Kim, Il-Seon Shin

المصدر: Frontiers in Psychiatry, Vol 15 (2024)

مصطلحات موضوعية: periventricular heterotopia, bipolar disorder, attention deficit-hyperactivity disorder, adolescent, depression, Psychiatry, RC435-571

الوصف: Periventricular heterotopia (PH) is a developmental malformation in the brain. Because the clinical symptoms are heterogeneous, few studies have investigated the psychiatric symptoms associated with PH. We describe the case of a 17-year-old male with bipolar disorder (BD), who had been treated for attention deficit-hyperactivity disorder (ADHD) and developmental delay in childhood. He had experienced depression for 1 year and was admitted to the emergency room following a suicide attempt. He was admitted to the psychiatric ward for further evaluation and treatment for elated mood, decreased need for sleep, increased sexuality, and delusion. The patient was diagnosed with BP-I disorder and PH via brain magnetic resonance imaging. After combined treatment with valproic acid and aripiprazole, his manic symptoms stabilized. To our knowledge, this is the first report of an adolescent PH case with a history of early onset BD and ADHD in childhood.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1289850/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/d896eeed3bf9403288bffcd8400619b3Test

المؤلفون: Ji-Su Kim, Seon-Hwa Baek, Honey Kim, Ju-Wan Kim, Hee-Ju Kang, Seunghyong Ryu, Ju-Yeon Lee, Jae-Min Kim, Sung-Wan Kim

المصدر: Frontiers in Psychiatry, Vol 14 (2023)

مصطلحات موضوعية: suicide, cognitive function, schizophrenia, early psychosis, depression, Psychiatry, RC435-571

الوصف: IntroductionSuicide is a major concern for patients with recent-onset schizophrenia. We hypothesized that preserved cognitive function might be associated with a higher level of suicidality in patients with schizophrenia. We investigated the associations between cognitive function and suicidal ideation (SI) in young patients recently diagnosed with a psychotic disorder.MethodsThis study analyzed data from a naturalistic clinical cohort study that comprised 402 patients with schizophrenia spectrum disorder. Patients with a treatment duration of ≤5 years and an age range of 15–39 years were enrolled. Participants were categorized into two groups based on SI as assessed by the Columbia Suicidal Severity Rating Scale. We collected demographic and clinical data and administered psychiatric, neurocognitive, and social cognitive measures.ResultsAmong participants, 52% reported experiencing SI. Patients with SI were significantly younger and had a longer duration of untreated psychosis (DUP) than those without it. The Positive and Negative Syndrome Scale-general psychopathology score was significantly higher in the SI group. Scores on the Calgary Depression Scale for Schizophrenia, Perceived Stress Scale, Beck Depression Inventory (BDI), and Beck Hopelessness Scale were significantly higher among patients with SI, while scores on the Subjective Well-being Under Neuroleptics-Short Form and Brief Resilience Scale were significantly lower compared to those without it. Patients with SI demonstrated significantly higher scores on the verbal and visual learning test, false belief task, picture stories task, and Controlled Oral Word Association Test. They also completed the Trail Making Test (TMT) parts A and B in significantly less time than those without it. After adjusting for age, DUP, and scores on the BDI, group differences in scores on the verbal and visual learning tests, TMT (parts A and B), and the false belief task, and the picture story task remained significant.DiscussionOur results suggest that along with traditional risk factors, better cognitive function may also be a major risk factor for suicidality in patients with schizophrenia. Providing psychological support and cognitive interventions is essential for young patients with recent-onset schizophrenia spectrum disorders, particularly those with high levels of depression, hopelessness, perceived stress, low resilience, and good cognitive function.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1276511/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/cfb625a586fe40ffb2ccd74f7d0a6188Test

المؤلفون: Wonsuk Choi, Hee-Ju Kang, Ju-Wan Kim, Hee Kyung Kim, Ho-Cheol Kang, Ju-Yeon Lee, Sung-Wan Kim, Robert Stewart, Jae-Min Kim

المصدر: Frontiers in Psychiatry, Vol 14 (2023)

مصطلحات موضوعية: age, suicide, prediction, depression, cholesterol, Psychiatry, RC435-571

الوصف: IntroductionThis study investigated the effects of total cholesterol levels on prevalent, and incident suicidal behaviors according to age group (

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1095579/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/08da573cfa1c47f7a7e9758f08eb8040Test

المؤلفون: Sung-Wan Kim, In-Hoo Park, Mina Kim, A-La Park, Min Jhon, Ju-Wan Kim, Hee-Ju Kang, Seunghyong Ryu, Ju-Yeon Lee, Jae-Min Kim

المصدر: BMC Psychiatry, Vol 21, Iss 1, Pp 1-8 (2021)

مصطلحات موضوعية: Depression, COVID-19, gratitude, loneliness, stress, exercise, Psychiatry, RC435-571

الوصف: Abstract Background The risk of depression has risen in the general population during the COVID-19 epidemic. This study was conducted to explore risk and protective factors associated with depression among the general population uninfected by COVID-19. Methods A cross-sectional study was conducted with 1,500 representative South Korean citizens aged 19–65 years through an anonymous online survey. Depression was defined as a Patient Health Questionnaire-9 score of 10 or higher. Other questionnaires included one measuring psycho-behavioural and social changes, and stress, due to COVID-19, a six-item version of the Gratitude Questionnaire (GQ-6), and a three-item version of the UCLA loneliness scale. Results Of the 1492 participants not infected by COVID-19, 312 (20.9%) exhibited depression. Multiple logistic regression analysis revealed that depression was positively associated with COVID-19-related stress and psycho-behavioural variables such as disturbances in eating and sleeping, younger age, smoking, underlying mental illness, and loneliness scale scores. In contrast, exercise three or more times per week and GQ-6 scale scores were inversely associated with depression. Conclusion During the COVID-19 pandemic, maintaining daily routines including eating, sleeping, and regular exercise and focusing on gratitude may be important for the prevention of depression. In addition, more attention should be paid to vulnerable populations, including young people, those with mental illnesses, and smokers, who might be more susceptible to depression.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-244XTest

الوصول الحر: https://doaj.org/article/05a780beb78c45ecaf2d832733b26c6aTest

المؤلفون: Ju-Yeon Lee, Robert Stewart, Hee-Ju Kang, Ju-Wan Kim, Min Jhon, Sung-Wan Kim, Il-Seon Shin, Jae-Min Kim

المصدر: Frontiers in Psychiatry, Vol 13 (2022)

مصطلحات موضوعية: depression, childhood abuse, social support, pharmacotherapy, treatment outcome, Psychiatry, RC435-571

الوصف: ObjectivesThis study was performed to investigate the roles of childhood abuse and social support in predicting short- and long-term pharmacological treatment outcomes in outpatients with depressive disorders in a naturalistic 1-year prospective design.MethodsPatients were recruited at a university hospital in South Korea between March 2012 and April 2017. Subjects with stepwise pharmacotherapy (switching, augmentation, combination, and mixture of these approaches) included 1246 patients at 12-week points in the acute treatment response and 1,015 patients at 12-months in the long-term treatment response. Remission was defined as Hamilton Depression Rating Scale score ≤ 7. Exposure to three types of childhood abuse (physical, emotional, and sexual) before the age of 16 and perceived social support were assessed at baseline.ResultsIndividual associations of childhood abuse were associated with poorer treatment outcomes in the 12-month long-term phase, and no significant individual associations were found for social support level with any period outcome. In combination, any child abuse, emotional abuse, and physical abuse were significantly associated with long-term 12-month remission rate in the presence of higher level of social support after adjustment with significant interaction terms. However, no significant interactions were found with sexual abuse.ConclusionSynergistic interactive effects of child abuse and social support levels on treatment outcomes in depressive patients were found during long-term pharmacotherapy. Thus, depressed patients with a history of childhood abuse may require specialized clinical approaches, including social support, to enhance the long-term treatment outcomes.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.803639/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/57a34c7937e649d38e7924ee2511cb85Test

المؤلفون: Jae-Min Kim, Ha-Yeon Kim, Hee-Joon Lee, Ju-Wan Kim, Hee-Ju Kang, Sung-Wan Kim, Il-Seon Shin, Byeong Jo Chun, Robert Stewart

المصدر: Frontiers in Psychiatry, Vol 12 (2021)

مصطلحات موضوعية: folate, suicidality, prediction, depression, pharmacotherapy, Psychiatry, RC435-571

الوصف: Background: The effects of serum folate levels on suicidal behavior, strongly associated with depression, have not been investigated. Therefore, this study investigated the associations between serum folate levels and suicidal behavior in patients with depressive disorders.Methods: Serum folate levels were measured at baseline in 1,094 patients with depressive disorder, 884 of whom were followed during a 12-month period of stepwise pharmacotherapy. Suicidal behaviors evaluated at baseline were (i) previous suicide attempt and (ii) baseline suicidal severity; behaviors evaluated at follow-up were (iii) increased suicidal severity and iv) fatal/non-fatal suicide attempt. Associations of serum folate levels with four types of suicidal behaviors were analyzed using logistic regression models after adjustment for relevant covariates; they were also examined using area under receiver operating characteristic (AUROC) curve analyses.Results: Reduced serum folate levels (

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2021.747228/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/96ae659e08304fd2bc5c19c0a7760b03Test

المؤلفون: Hee-Ju Kang, Ju-Wan Kim, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin, Young Joon Hong, Youngkeun Ahn, Myung-Ho Jeong, Jae-Min Kim

المصدر: Frontiers in Psychiatry, Vol 12 (2021)

مصطلحات موضوعية: acute coronary syndrome, depression, tumor necrosis factor-α, gene association study, interaction, Psychiatry, RC435-571

الوصف: Background: Considering the association of inflammation with suicide and acute coronary syndrome (ACS), we investigated the individual and interactive effects of serum tumor necrosis factor-alpha (sTNFα) levels and two polymorphisms (−850 C/T and −308 G/A) on suicidal ideation (SI) after ACS.Methods: The SI status using items on the Montgomery–Åsberg Depression Rating Scale (MADRS), related covariates including sociodemographic and clinical characteristics, sTNFα levels, and tumor necrosis factor-alpha (TNF-α) polymorphisms were evaluated in 969 patients within 2 weeks after ACS. Of the patients, 711 were evaluated 1 year later for SI. Multivariate logistic regression models were used to calculate individual and interactive associations after adjusting for the covariates.Results: Higher (vs. lower) sTNFα levels and the −850 C/T or T/T (vs. C/C) polymorphism were significantly associated with SI 2 weeks after ACS, while only higher sTNFα levels were significantly associated with SI after 1 year. Significant interactive effects were detected between sTNFα (higher) levels and the −850 C/T (C/C or C/T) polymorphism on SI 2 weeks after ACS and between the two (−850 CC or CT and −308 G/A or AA) polymorphisms on SI 1 year after ACS.Conclusions: The sTNFα level and two polymorphisms (−850C/T and −308 G/A), separately or in combination, could be time-specific biomarkers for SI in ACS. Focused interventions for ACS patients at risk of SI might reduce the suicidal burden in patients with ACS.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2021.739823/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/bb0d1952cf104a80b66ef8da5d866099Test

المؤلفون: Ju-Wan Kim, Hee-Ju Kang, Min Jhon, Seunghyong Ryu, Ju-Yeon Lee, Seung-Ji Kang, Sook-In Jung, Il-Seon Shin, Sung-Wan Kim, Robert Stewart, Jae-Min Kim

المصدر: Frontiers in Psychiatry, Vol 12 (2021)

مصطلحات موضوعية: depression, anxiety, COVID-19 inpatients, insomnia, suicide idea, Psychiatry, RC435-571

الوصف: Background: Hospital isolation for COVID-19 may cause significant psychological stress. The association between COVID-19 symptoms and psychological symptoms has not been systematically studied. We investigated the effects of telephonic intervention on the relationship between psychological symptoms and COVID-19 symptoms at the time of hospitalization and 1 week later.Method: We screened 461 patients with COVID-19 for psychiatric symptoms from February 29, 2020, to January 3, 2021. In total, 461 patients were evaluated 2 days after admission, and 322 (69.8%) were followed 1 week later. To assess anxiety and depressive symptoms, the Hospital Anxiety and Depression Scale (HADS) was administered to patients once per week. The Insomnia Severity Index (ISI) and item 9 of the Beck Depression Inventory (BDI-9) were used weekly to assess insomnia and suicidal ideation.Results: Of 461 enrolled patients, we observed clinically meaningful psychological anxiety symptoms (in 75/16.3% of patients), depression (122/26.5%), insomnia (154/33.4%), and suicidal ideation (54/11.7%). Commonly reported COVID-19 symptoms are cough/sputum/sneezing (244, 52.9%), headache/dizziness (98, 21.3%), myalgia (113, 24.5%), and sore throat (89, 19.3%). Compared to baseline, significant improvements were found in anxiety, depression, and suicidal ideation at 1 week. No significant group differences in ISI score were observed.Conclusions: COVID-19 symptoms at baseline had a significant and persistent negative impact on anxiety and depression at admission and at 1 week after hospitalization. Early intervention is essential to improve the outcomes of patients with mental illness.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2021.721532/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/d70fa5db09d4454381ad3bd9d4a1e466Test

المؤلفون: Young-Hyuk Kim, Seunghyong Ryu, Hee-Jung Nam, Mina Kim, Min Jhon, Ju-Yeon Lee, Jae-Min Kim, Min Ho Shin, Young-Chul Chung, Sung-Wan Kim

المصدر: Frontiers in Psychiatry, Vol 11 (2020)

مصطلحات موضوعية: weight gain, food craving, schizophrenia, First-Episode Psychosis (FEP), stress, depression, Psychiatry, RC435-571

الوصف: Objectives: Food cravings may cause weight gain in patients with schizophrenia. This study investigated psychological characteristics associated with food cravings in patients with first-episode psychosis.Methods: This study analyzed data from a clinical cohort of first-episode psychosis patients taking antipsychotics for 3 months or less. The strength of food cravings was measured using the General Food Cravings Questionnaire-Trait (G-FCQ-T). Psychological characteristics and psychiatric symptoms were investigated with the Positive and Negative Symptom Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Social and Occupational Functioning Assessment Scale, Rosenberg Self-Esteem Scale (RSES), and Perceived Stress Scale (PSS). Clinical characteristics were compared according to significant weight gain (≥10% increase in body weight compared to baseline) over 3 months. Associations between the G-FCQ-T and other psychiatric scales were investigated. We conducted sex-stratified analyses.Results: In total, 182 patients (78 males and 104 females) with first-episode psychosis were enrolled in this study. In females, the G-FCQ-T total score at baseline was associated with baseline body weight and significant weight gain over 3 months. The PSS scales were significantly associated the G-FCQ-T total and all subscale scores in female participants. Scores on the RSES and CDSS were significantly associated with the G-FCQ-T total score and with the preoccupation and loss of control subscale scores. The PANSS negative and general subscales were significantly associated with the positive outcome expectancy and loss of control subscales of the G-FCQ-T, respectively. In males, the only significant association was between the loss of control subscale and RSES scores. Linear regression analysis showed significant associations of PSS scores with the total and all subscale scores of the G-FCQ-T despite the loss of significance for other variables.Conclusion: These results indicate that the food cravings in patients with first-episode psychosis, which were associated with weight gain, were influenced by perceived stress in females. To reduce food cravings in female patients with schizophrenia, interventions aimed at perceived stress should be considered.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2020.587486/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/72568412e4284aa1899cc752ab9a5022Test

المؤلفون: João Vian, Círia Pereira, Victor Chavarria, Cristiano Köhler, Brendon Stubbs, João Quevedo, Sung-Wan Kim, André F. Carvalho, Michael Berk, Brisa S. Fernandes

المصدر: BMC Medicine, Vol 15, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: Depression, Psychiatry, Inflammation, Renin–angiotensin system, Angiotensin, ATR1, Medicine

الوصف: Abstract Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin–angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensin-converting enzyme inhibitors or angiotensin receptor blockers had positive effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin–angiotensin system act on inflammatory pathways implicated in depression. Both preclinical and clinical data suggest that these drugs possess antidepressant properties. In light of these results, angiotensin system-blocking agents offer new horizons in mood disorder treatment.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12916-017-0916-3Test; https://doaj.org/toc/1741-7015Test

الوصول الحر: https://doaj.org/article/f5aac610153743d4a1641a4e354f0807Test