دورية أكاديمية
Neurophysiological explorations across the spectrum of psychosis, autism, and depression, during wakefulness and sleep: protocol of a prospective case–control transdiagnostic multimodal study (DEMETER)
| العنوان: | Neurophysiological explorations across the spectrum of psychosis, autism, and depression, during wakefulness and sleep: protocol of a prospective case–control transdiagnostic multimodal study (DEMETER) |
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| المؤلفون: | Lucarini, Valeria, Alouit, Anaëlle, Yeh, Delphine, Le Coq, Jeanne, Savatte, Romane, Charre, Mylène, Louveau, Cécile, Houamri, Meryem Benlaifa, Penaud, Sylvain, Gaston-Bellegarde, Alexandre, Rio, Stéphane, Drouet, Laurent, Elbaz, Maxime, Becchio, Jean, Pourchet, Sylvain, Pruvost-Robieux, Estelle, Marchi, Angela, Moyal, Mylène, Lefebvre, Aline, Chaumette, Boris, Grice, Martine, Lindberg, Påvel, G, Dupin, Lucile, Piolino, Pascale, Lemogne, Cédric, Léger, Damien, Gavaret, Martine, Krebs, Marie-Odile, Iftimovici, Anton |
| المساهمون: | Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), GHU Paris Psychiatrie et Neurosciences, Laboratoire Mémoire, Cerveau et Cognition (LMC2 (URP_7536)), Université Paris Cité (UPCité), Centre du Sommeil et de la Vigilance Paris, Hôpital Hôtel-Dieu Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Epileptologie et de Rythmologie Cérébrale Hôpital de la Timone, AP-HM, Aix Marseille Université (AMU)-Hôpital de la Timone CHU - APHM (TIMONE), Unité de recherche en NeuroImagerie Applicative Clinique et Translationnelle (UNIACT), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre Neurosciences intégratives et Cognition / Integrative Neuroscience and Cognition Center (INCC - UMR 8002), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Sommeil-Vigilance-Fatigue et Santé Publique (VIFASOM (URP_7330)), Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA)-Université Paris Cité (UPCité) |
| المصدر: | ISSN: 1471-244X ; BMC Psychiatry ; https://hal.science/hal-04314404Test ; BMC Psychiatry, 2023, 23 (1), pp.860. ⟨10.1186/s12888-023-05347-x⟩. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Neurophysiology, EEG microstates, Sleep, Sensorimotor integration, Speech, Virtual reality, Psychosis, Autism, Depression, Sense of self, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | International audience ; Background: Quantitative electroencephalography (EEG) analysis offers the opportunity to study high-level cognitive processes across psychiatric disorders. In particular, EEG microstates translate the temporal dynamics of neuronal networks throughout the brain. Their alteration may reflect transdiagnostic anomalies in neurophysiological functions that are impaired in mood, psychosis, and autism spectrum disorders, such as sensorimotor integration, speech, sleep, and sense of self. The main questions this study aims to answer are as follows: 1) Are EEG microstate anomalies associated with clinical and functional prognosis, both in resting conditions and during sleep, across psychiatric disorders? 2) Are EEG microstate anomalies associated with differences in sensorimotor integration, speech, sense of self, and sleep? 3) Can the dynamic of EEG microstates be modulated by a non-drug intervention such as light hypnosis?Methods: This prospective cohort will include a population of adolescents and young adults, aged 15 to 30 years old, with ultra-high-risk of psychosis (UHR), first-episode psychosis (FEP), schizophrenia (SCZ), autism spectrum disorder (ASD), and major depressive disorder (MDD), as well as healthy controls (CTRL) (N = 21 × 6), who will be assessed at baseline and after one year of follow-up. Participants will undergo deep phenotyping based on psychopathology, neuropsychological assessments, 64-channel EEG recordings, and biological sampling at the two timepoints. At baseline, the EEG recording will also be coupled to a sensorimotor task and a recording of the characteristics of their speech (prosody and turn-taking), a one-night polysomnography, a self-reference effect task in virtual reality (only in UHR, FEP, and CTRL). An interventional ancillary study will involve only healthy controls, in order to assess whether light hypnosis can modify the EEG microstate architecture in a direction opposite to what is seen in disease.Discussion: This transdiagnostic longitudinal ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04314404; https://hal.science/hal-04314404Test; https://hal.science/hal-04314404/documentTest; https://hal.science/hal-04314404/file/Lucarini%20et%20al.%20-%202023%20-%20Neurophysiological%20Explorations%20Across%20the%20Spectru.pdfTest |
| DOI: | 10.1186/s12888-023-05347-x |
| الإتاحة: | https://doi.org/10.1186/s12888-023-05347-xTest https://hal.science/hal-04314404Test https://hal.science/hal-04314404/documentTest https://hal.science/hal-04314404/file/Lucarini%20et%20al.%20-%202023%20-%20Neurophysiological%20Explorations%20Across%20the%20Spectru.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.AF9F47FE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12888-023-05347-x |
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