Orphan receptor GPR158 controls stress-induced depression
| العنوان: | Orphan receptor GPR158 controls stress-induced depression |
|---|---|
| المؤلفون: | Brian S. Muntean, Hyung Bae Kwon, Won Chan Oh, Xiangyang Xie, Keqiang Xie, Rachel Satterfield, Samuel M. Young, Chenghui Song, Baoji Xu, Kenneth J. Renner, Kirill A. Martemyanov, Jazmine D. W. Yaeger, Cesare Orlandi, Laurie P. Sutton, Alice Filippini |
| المصدر: | eLife, Vol 7 (2018) eLife |
| بيانات النشر: | eLife Sciences Publications Ltd, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Mouse, QH301-705.5, Science, Regulator, Prefrontal Cortex, orphan receptors, General Biochemistry, Genetics and Molecular Biology, Receptors, G-Protein-Coupled, Mice, 03 medical and health sciences, stress, 0302 clinical medicine, Downregulation and upregulation, GPCR signaling, medicine, Animals, Humans, Chronic stress, Biology (General), Prefrontal cortex, Orphan receptor, General Immunology and Microbiology, business.industry, General Neuroscience, General Medicine, medicine.disease, 3. Good health, 030104 developmental biology, Mood, Gene Expression Regulation, Mood disorders, depression, Major depressive disorder, Medicine, business, Neuroscience, Stress, Psychological, 030217 neurology & neurosurgery, Research Article, Human |
| الوصف: | Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure to chronic stress contributes to the development of depression and anxiety. However, the molecular mechanisms underlying stress-responsive behaviors are not fully understood. Here, we identified the orphan receptor GPR158 as a novel regulator operating in the prefrontal cortex (PFC) that links chronic stress to depression. GPR158 is highly upregulated in the PFC of human subjects with major depressive disorder. Exposure of mice to chronic stress also increased GPR158 protein levels in the PFC in a glucocorticoid-dependent manner. Viral overexpression of GPR158 in the PFC induced depressive-like behaviors. In contrast GPR158 ablation, led to a prominent antidepressant-like phenotype and stress resiliency. We found that GPR158 exerts its effects via modulating synaptic strength altering AMPA receptor activity. Taken together, our findings identify a new player in mood regulation and introduce a pharmacological target for managing depression. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953c382784a5d06b7410646a1faf2cdfTest https://elifesciences.org/articles/33273Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....953c382784a5d06b7410646a1faf2cdf |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |