دورية أكاديمية
Repeated local delivery of hyaluronic acid gel as adjunctive treatment of residual pockets in periodontitis patients undergoing supportive periodontal care. A randomized controlled clinical trial
| العنوان: | Repeated local delivery of hyaluronic acid gel as adjunctive treatment of residual pockets in periodontitis patients undergoing supportive periodontal care. A randomized controlled clinical trial |
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| المؤلفون: | Bertl, Kristina, Vlachou, Stefania, Pandis, Nikolaos, Zampelis, Antonios, Stavropoulos, Andreas |
| بيانات النشر: | Malmö universitet, Odontologiska fakulteten (OD) Sigmund Freud Univ Vienna, Fac Med, Dept Periodontol, Dent Clin, Freudpl 3, A-1020 Vienna, Austria.;Blekinge Hosp, Dept Periodontol, HalsovagenByggnad 13, S-37141 Karlskrona, Sweden. Univ Geneva, Div Regenerat Dent Med & Periodontol, CUMD, Rue Michel Servet 1, CH-1211 Geneva 4, Switzerland. Univ Bern, Sch Dent Med, Dept Orthodont & Dentofacial Orthoped, Freiburgstr 7, CH-3010 Bern, Switzerland. Drottninggatan 27, S-65225 Gotene, Sweden.;Publ Dent Hlth Serv, Specialist Clin Endodont & Periodontol, Hagagatan 6, S-65220 Karlstad, Varmland, Sweden. Blekinge Hosp, Dept Periodontol, HalsovagenByggnad 13, S-37141 Karlskrona, Sweden.; Med Univ Vienna, Univ Clin Dent, Div Conservat Dent & Periodontol, Sensengasse 2a, A-1090 Vienna, Austria.;Univ Bern, Sch Dent Med, Dept Periodontol, Freiburgstr 7, CH-3010 Bern, Switzerland. |
| سنة النشر: | 2024 |
| المجموعة: | Malmö University Electronic Publishing (MUEP) |
| مصطلحات موضوعية: | Adjunct treatment, Hyaluronic acid, Periodontitis, Pocket closure, Randomized controlled clinical trial, Supportive periodontal care, Dentistry, Odontologi |
| الوصف: | Objectives To assess the effect of hyaluronic acid (HyA) application as adjunct to re-instrumentation of residual pockets in patients undergoing regular supportive periodontal care (SPC). Methods Chronic periodontitis patients (stage III and IV, grade B and C) with 4 interproximal residual pockets were randomly assigned to the test (HyA gel) or control (saline) group. After subgingival instrumentation, test or control substance was applied subgingivally, then daily supragingivally for 3 months, and if required a second time after subgingival re-instrumentation after 3 months. Clinical and patient reported outcome parameters were recorded every 3 months for 12 months. Pocket closure [probing pocket depth (PPD) <= 4mm with absence of bleeding on probing (BoP) at PPD = 4mm] was the main outcome parameter. Results Fifty-six patients (221 experimental sites) were analysed. Pocket closure was achieved in 56.8 and 46.6% of the experimental sites in the test and control group, respectively (p > 0.05), while median PPD and PPD distribution (< 5mm/5mm/ > 5mm) differed significantly between groups in favour of the test group, at 12 months. Further, significantly fewer sites in the HyA group required re-instrumentation at 3 months, and sites in the HyA group showed a tendency for lower odds to remain diseased compared to the control group (OR 0.48, 95%CI 0.22-1.06). The odds for a site to remain diseased after 12 months increased significantly in the presence of plaque (OR 7.94, 95%CI 4.12-15.28), but in general, decreased significantly over time (OR 0.48, 95%CI 0.28-0.81). Conclusion Re-instrumentation of residual pockets in SPC patients, per se, leads to a significant increase in pocket closure over time; this was impeded by poor plaque control. Repeated local application of HyA results in fewer sites requiring re-instrumentation and might slightly improve the rate of pocket closure. (clinicaltrials.gov registration nr. NCT04792541). Clinical relevance HyA gel is easy to apply, well accepted by patients, and ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-01-171496-7 0-01-171496-4 |
| العلاقة: | Clinical Oral Investigations, 1432-6981, 2024, 28:2; orcid:0000-0001-8161-3754; http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-66541Test; PMID 38376596; ISI:001171496400001; Scopus 2-s2.0-85185492305 |
| DOI: | 10.1007/s00784-024-05505-9 |
| الإتاحة: | https://doi.org/10.1007/s00784-024-05505-9Test http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-66541Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.24BF0F5E |
| قاعدة البيانات: | BASE |
| ردمك: | 9780011714967 0011714964 |
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| DOI: | 10.1007/s00784-024-05505-9 |