دورية أكاديمية
GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
| العنوان: | GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders |
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| المؤلفون: | Italia M., Ferrari E., Di Luca M., Gardoni F. |
| المساهمون: | M. Italia, E. Ferrari, M. Di Luca, F. Gardoni |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | AMPA receptor, Autoimmunity, Dendritic spine, Glutamate, Neurodegeneration, Synaptic plasticity, Synaptic transmission, Settore BIO/14 - Farmacologia |
| الوصف: | In the mammalian brain, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) play a fundamental role in the activation of excitatory synaptic transmission and the induction of different forms of synaptic plasticity. The modulation of the AMPAR tetramer subunit composition at synapses defines the functional properties of the receptor. During the last twenty years, several studies have evaluated the roles played by each subunit, from GluA1 to GluA4, in both physiological and pathological conditions. Here, we have focused our attention on GluA3-containing AMPARs, addressing their functional role in synaptic transmission and synaptic plasticity and their involvement in a variety of brain disorders. Although several aspects remain to be fully understood, GluA3 is a widely expressed and functionally relevant subunit in AMPARs involved in several brain circuits, and its pharmacological modulation could represent a novel approach for the rescue of altered glutamatergic synapses associated with neurodegenerative and neurodevelopmental disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34743951; info:eu-repo/semantics/altIdentifier/wos/WOS:000717634000001; volume:161; firstpage:1; lastpage:10; numberofpages:10; journal:NEUROBIOLOGY OF DISEASE; https://hdl.handle.net/2434/918474Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118594426 |
| DOI: | 10.1016/j.nbd.2021.105539 |
| الإتاحة: | https://doi.org/10.1016/j.nbd.2021.105539Test https://hdl.handle.net/2434/918474Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.854C0FE9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.nbd.2021.105539 |
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