التفاصيل البيبلوغرافية
| العنوان: |
Structural brain correlates of dementia in Huntington's disease |
| المؤلفون: |
Martínez Horta, Saul, Sampedro, Frederic, Horta, Andrea, Pérez-Pérez, Jesús, Pagonabarraga Mora, Javier, Gómez-Ansón, Beatriz, Kulisevsky, Jaime, Universitat Autònoma de Barcelona |
| سنة النشر: |
2020 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
Huntington's disease, Dementia, Neuropsychology, Mild cognitive impairment, Movement disorders |
| الوصف: |
Altres ajuts: The present study was partially funded by the "Human Biology Project Grant" of the Huntington's Disease Society of America (USA). ; Huntington's disease (HD) is a fatal genetic neurodegenerative disorder with no effective treatment currently available. Progressive basal ganglia and whole-brain atrophy and concurrent cognitive deterioration are prototypical aspects of HD. However, the specific patterns of brain atrophy underlying cognitive impairment of different severity in HD are poorly understood. The aim of this study was to investigate the specific structural brain correlates of major cognitive deficits in HD and to explore its association with neuropsychological indicators. Thirty-five symptomatic early-to-mild HD patients and 15 healthy controls (HC) with available T1-MRI imaging were included in this study. In this cross-sectional study, HD patients were classified as patients with (HD-Dem) and without (HD-ND) major cognitive impairment in the range of dementia. This classification was based on previously validated PD-CRS cutoff scores for HD. Differences in brain atrophy across groups were studied by means of grey-matter volume voxel-based morphometry (GMV-VBM) and cortical thickness (Cth). Voxelwise and vertexwise general linear models were used to assess the group comparisons, controlling for the effects of age, sex, education, CAG repeat length and severity of motor symptoms. Clusters surviving p < 0.05 and family-wise error (FWE) correction were considered statistically significant. In order to characterize the impact on cognitive performance of the observed brain differences across groups, GMV and Cth values in the set of significant regions were computed and correlated with specific neuropsychological tests. All groups had similar sociodemographic profiles, and the HD groups did not significantly differ in terms of CAG repeat length. Compared to HC, both HD groups exhibited significant atrophy in multiple subcortical and parietal brain regions. However, compared to HC and HD-ND ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Instituto de Salud Carlos III PI17-001885; NeuroImage; Vol. 28 (september 2020); https://ddd.uab.cat/record/232728Test; urn:10.1016/j.nicl.2020.102415; urn:oai:ddd.uab.cat:232728; urn:pmcid:PMC7519361; urn:pmc-uid:7519361; urn:pmid:32979842; urn:oai:pubmedcentral.nih.gov:7519361; urn:oai:egreta.uab.cat:publications/2bd58a2e-029c-4a94-b06f-c74d45d3691a |
| الإتاحة: |
https://ddd.uab.cat/record/232728Test |
| حقوق: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.14BF9797 |
| قاعدة البيانات: |
BASE |
