دورية أكاديمية
Comparison between centralised and decentralised supply chain of autologous CAR-T therapies: a UK case study based on discrete event simulation
| العنوان: | Comparison between centralised and decentralised supply chain of autologous CAR-T therapies: a UK case study based on discrete event simulation |
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| المؤلفون: | Lam, C, Meinert, Edward, Yang, A, Zhanfeng, C |
| بيانات النشر: | Elsevier England |
| سنة النشر: | 2021 |
| المجموعة: | PEARL (Plymouth Electronic Archiv & ResearchLibrary, Plymouth University) |
| مصطلحات موضوعية: | CAR T, centralization, decentralization, discrete event simulation, manufacturing, supply chain |
| الوصف: | Decentralised (or distributed) manufacturing that takes place close to the point of care has been a manufacturing paradigm of heightened interest within the cell therapy domain due to the product being living cell material and the need for highly monitored and temperature-controlled supply chain, which has the potential to benefit from the close proximity between manufacturing and application. To compare the operational feasibility and cost implications of manufacturing autologous CAR-T products between centralised and decentralised schemes, a discrete event simulation model was built using ExtendSIM 9 for simulating the patient-to-patient supply chain from the collection of patient cells to the final administration of the CAR-T therapy in hospitals. Simulations were carried out for hypothetical systems in the United Kingdom with three demand levels, low (100 patients per annum), anticipated (200 patients per annum) and high (500 patients per annum), in order to assess resource allocation, cost per treatment and system resilience to demand changes and to quantify the risks of mix-ups within the supply chain for the delivery of CAR-T treatments. The simulation results show that, whilst centralised manufacturing offers better economies of scale, individual facilities in a decentralised system can spread facility costs across a greater number of treatments and better utilise resources at high demand levels (annual demand of 500 patients), allowing an overall more comparable cost per treatment. In general, raw material and consumable costs have shown to be one of the greatest cost drivers, of which genetic modification associated costs have shown to account for over one-third of the raw material and consumable costs. Turnaround time per treatment for the decentralised scheme is shown to be consistently lower than its centralised counterpart, as there is no need for product freeze-thaw, packaging and transportation, although time savings is shown to be insignificant in the UK case study due to its rather compact ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 433-451; Print-Electronic; application/pdf |
| اللغة: | English |
| تدمد: | 1465-3249 1477-2566 |
| العلاقة: | E-ISSN:1477-2566; http://hdl.handle.net/10026.1/16229Test |
| DOI: | 10.1016/j.jcyt.2020.08.007 |
| الإتاحة: | https://doi.org/10.1016/j.jcyt.2020.08.007Test http://hdl.handle.net/10026.1/16229Test |
| رقم الانضمام: | edsbas.C697F9EB |
| قاعدة البيانات: | BASE |
| تدمد: | 14653249 14772566 |
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| DOI: | 10.1016/j.jcyt.2020.08.007 |