التفاصيل البيبلوغرافية
| العنوان: |
Short-term respiratory outcomes in late preterm infants. |
| المؤلفون: |
Natile, Miria1 mirianatile@gmail.com, Ventura, Maria Luisa1 l.ventura@hsgerardo.com, Colombo, Marco1 dott.marco.colombo@gmail.com, Bernasconi, Davide2 davide_bernasconi@libero.it, Locatelli, Anna3 anna.locatelli@campus.unimib.it, Plevani, Cristina3 criple@libero.it, Valsecchi, Maria Grazia2 grazia.valsecchi@unimib.it, Tagliabue, Paolo1 p.taglaibue@hsgerardo.com |
| المصدر: |
Italian Journal of Pediatrics. 2014, Vol. 40 Issue 1, p1-18. 18p. |
| مصطلحات موضوعية: |
*LUNG diseases, *PULMONARY surfactant, *CHI-squared test, *CONFIDENCE intervals, *FISHER exact test, *PREMATURE infants, *MORTALITY, *T-test (Statistics), *U-statistics, *RETROSPECTIVE studies, *DATA analysis software, *DESCRIPTIVE statistics, *ODDS ratio, *THERAPEUTICS, *DISEASE risk factors |
| مصطلحات جغرافية: |
ITALY |
| مستخلص: |
Objective: To evaluate short-term respiratory outcomes in late preterm infants (LPI) compared with those of term infants (TI). Methods: A retrospective study conducted in a single third level Italian centre (2005-2009) to analyse the incidence and risk factors of composite respiratory morbidity (CRM), the need for adjunctive therapies (surfactant therapy, inhaled nitric oxide, pleural drainage), the highest level of respiratory support (mechanical ventilation - MV, nasal continuous positive airway pressure - N-CPAP, nasal oxygen) and the duration of pressure support (hours in N-CPAP and/or MV). Results: During the study period 14,515 infants were delivered. There were 856 (5.9%) LPI and 12,948 (89.2%) TI. CRM affected 105 LPI (12.4%), and 121 TI (0.9%), with an overall rate of 1.6%. Eighty-four LPI (9.8%) and 73 TI (0.56%) received respiratory support, of which 13 LPI (1.5%) and 16 TI (0.12%) were ventilated. The adjusted OR for developing CRM significantly increased from 3.3 (95%CI 2.0-5.5) at 37 weeks to 40.8 (95%CI 19.7-84.9%) at 34 weeks. The adjusted OR for the need of MV significantly increased from 3.4 (95%CI 1.2- 10) at 37 weeks to 34.4 (95%CI 6.7-180.6%) at 34 weeks. Median duration of pressure support was significantly higher at 37 weeks (66,6 h vs 40,5 h). Twin pregnancies were related to a higher risk of CRM (OR 4.3, 95%CI 2.6-7.3), but not independent of gestational age (GA). Cesarean section (CS) was associated with higher risk of CRM independently of GA, but the OR was lower in CS with labour (2.2, 95%CI 1.4-3.4 vs 3.0, 95%CI 2.1-4.2). Conclusions: In this single third level care study late preterm births, pulmonary diseases and supportive respiratory interventions were lower than previously documented. LPI are at a higher risk of developing pulmonary disease than TI. Infants born from elective cesarean sections, late preterm twins in particular and 37 weekers too might benefit from preventive intervention. [ABSTRACT FROM AUTHOR] |
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