Infiltration of effector regulatory T cells predicts poor prognosis of diffuse large B-cell lymphoma, not otherwise specified
| العنوان: | Infiltration of effector regulatory T cells predicts poor prognosis of diffuse large B-cell lymphoma, not otherwise specified |
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| المؤلفون: | Kazuki Iwaki, Uta Nishiwaki, Mayumi Fujimoto, Shoko Nakayama, Taiji Yokote, Ayami Takayama, Yasuichiro Nishimura, Toshikazu Akioka, Motomu Tsuji, Takuji Miyoshi, Jun Hatooka, Nobuya Hiraoka, Yuki Masuda |
| المصدر: | Blood Advances. 1:486-493 |
| بيانات النشر: | American Society of Hematology, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | education.field_of_study, Lymphoid Neoplasia, Population, FOXP3, hemic and immune systems, chemical and pharmacologic phenomena, Hematology, Biology, medicine.disease, Lymphoma, 03 medical and health sciences, 0302 clinical medicine, International Prognostic Index, Antigen, Tumor progression, 030220 oncology & carcinogenesis, mental disorders, Immunology, medicine, Cytotoxic T cell, education, Diffuse large B-cell lymphoma, psychological phenomena and processes, 030215 immunology |
| الوصف: | Regulatory T cells (Tregs) specifically express the transcription factor forkhead box P3 (FOXP3) and contribute to tumor progression. FOXP3-positive cells have been recently proven to be heterogeneous in phenotype and function, including effector Tregs (eTregs), naive Tregs, and non-Tregs, which harbor no suppressive function. Therefore, it is crucial to investigate the “true Treg (eTreg)” population, rather than the entire FOXP3 population, with regards to their effect on tumor immunity. In particular, in diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), FOXP3-positive cells correlated with a better prognosis. The present study sought to evaluate the relationship between the prognosis of DLBCL, NOS patients and the infiltration of true Tregs by employing dual immunostaining with FOXP3 and cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4). CTLA-4 is a negative immunomodulatory known to be expressed by eTregs, but not by non-Tregs. Lymph nodes from 82 nodal DLBCL, NOS patients were stained with anti-FOXP3 and anti–CTLA-4 antibodies. A high infiltration of FOXP3-positive cells was associated with a significantly better prognosis than patients with low levels of FOXP3-positive cells for overall survival (OS) ( P = .0233). In sharp contrast, a high infiltration of FOXP3/CTLA-4 double-positive cells was significantly associated with a poor prognosis than patients with low levels of FOXP3/CTLA-4 double-positive cells for OS ( P = .0121) and progression-free survival ( P = .0171), independent of the international prognostic index. FOXP3/CTLA-4 double-positive cells, eTregs, play an important role in DLBCL, NOS progression. |
| تدمد: | 2473-9537 2473-9529 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4467f8383348ede3a7076602e750e7ecTest https://doi.org/10.1182/bloodadvances.2016000885Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4467f8383348ede3a7076602e750e7ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24739537 24739529 |
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