Diffusion-Weighted Magnetic Resonance Imaging in Peritoneal Carcinomatosis from Ovarian Cancer: Diagnostic performance in correlation with surgical findings
| العنوان: | Diffusion-Weighted Magnetic Resonance Imaging in Peritoneal Carcinomatosis from Ovarian Cancer: Diagnostic performance in correlation with surgical findings |
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| المؤلفون: | Priya Bhosale, Concepción González Hernando, Raquel Saiz Martínez, Javier Garcia Prado, Luis Chiva, David Varillas Delgado, Javier Blazquez Sanchez |
| المصدر: | DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria Universidad Francisco de Vitoria |
| بيانات النشر: | European Journal of Radiology, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Neoplasm, Residual, Sensitivity and Specificity, Cytoreduction Surgical Procedures, Ovarian cancer, Positron Emission Tomography Computed Tomography, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Prospective cohort study, Peritoneal Neoplasms, Ovarian Neoplasms, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Diffusion weighted imaging, General Medicine, Middle Aged, Debulking, medicine.disease, Prognosis, Diffusion Magnetic Resonance Imaging, Conventional PCI, Peritoneal Cancer Index, Female, Whole-body magnetic resonance imaging, Peritoneum, business, Nuclear medicine, Tomography, X-Ray Computed, Peritoneal carcinomatosis, Diffusion MRI, MR imaging |
| الوصف: | Purpose Ovarian cancer (OC) is the commonest cause of death by gynaecological cancer in developed countries. Peritoneal carcinomatosis (PC) complete debulking without residual disease of >1 cm is the best prognostic predictor in advanced OC. PC is assessed with Computed tomography (CT). CT accuracy and cytoreduction success predictive ability are limited. PET/CT is not an imaging standard for PC. PC shows high signal foci in Diffusion-weighted magnetic resonance imaging (DWI MRI). We assessed the diagnostic performance (DP) and tumour burden correlation of Whole body DWI with background suppression MRI (WB-DWIBS/MRI) in PC of suspected OC using the Peritoneal Cancer Index (PCI), referring to cytoreduction surgery as the standard reference. Method Fifty patients with suspicion of disseminated OC underwent cytoreduction and WB-DWIBS/MRI. The PCI scores tumour burden (0–3) in 13 anatomical regions (global range of 0–39). Two radiologists (Rad1/Rad2) assessed the PCI preoperatively and with surgical findings. We evaluated regional and global DP, the interobserver agreement (Cohen´s kappa coefficient), statistical differences (McNemar test) and tumour burden (Pearson’s test). Results 72% (36/50) were epithelial OC and 78% (39/50) achieved complete cytoreduction. Global-PCI correlation was 0.762 (Rad1) with DP: Sensitivity 0.84, specificity 0.89, accuracy 0.89, and kappa 0.41. Average global-PCI was 7. The pelvis and right hypochondrium showed the highest positive rate and DP, while the intestinal regions presented the lowest. Previous studies reported higher sensitivity than CT or PET/CT, although only a few used the PCI. Conclusions WB-DWIBS/MRI is reliable to depict, quantify and to predict complete cytoreductive surgery in OC PC. pre-print 2737 KB |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bdc580a0615006b9338fc325619f90Test http://hdl.handle.net/10641/2241Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....79bdc580a0615006b9338fc325619f90 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |