دورية أكاديمية
Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes: Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers
| العنوان: | Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes: Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers |
|---|---|
| المؤلفون: | Shaw, Bronwen E., Logan, Brent R., Kiefer, Deidre M., Chitphakdithai, Pintip, Pedersen, Tanya L., Abdel-Azim, Hisham, Abidi, Muneer H., Akpek, Gorgun, Diaz, Miguel A., Artz, Andrew S., Dandoy, Christopher, Gajewski, James L., Hematti, Peiman, Kamble, Rammurti T., Kasow, Kimberley A., Lazarus, Hillard M., Liesveld, Jane L., Majhail, Navneet S., O'Donnell, Paul V., Olsson, Richard F., Savani, Bipin N., Schears, Raquel M., Stroncek, David F., Switzer, Galen E., Williams, Eric P., Wingard, John R., Wirk, Baldeep M., Confer, Dennis L., Pulsipher, Michael A. |
| المصدر: | Biology of Blood and Marrow Transplantation, 21(10) |
| سنة النشر: | 2015 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Filgrastim, Hospitals, Low-Volume, Adolescent, PBSC, Bone marrow, Unrelated donor, Socioeconomic status, Race, Cytomegalovirus Infections, Humans, Female, High-Volume, Body Mass Index, Blood Cell Count, Continental Population Groups, Adult, Donor toxicities, Donor center, Anesthesia, Bone Marrow Transplantation |
| الوصف: | Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index (BMI), and age in unrelated donors undergoing collection at National Marrow Donor Program (NMDP) centers. We hypothesized that other important factors (race, socioeconomic status (SES), and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2,726 bone marrow (BM) and 6,768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week post donation (p=0.017). For BM donors, black males reported significantly higher levels of pain (OR=1.90, CI=1.14-3.19, p=0.015). No differences were noted by SES groups. BM donors from low volume centers reported more toxicity (OR=2.09, CI=1.26-3.46, p=0.006). In conclusion, race and SES have a minimal effect on donation associated symptoms. However, donors from centers performing ≤1 BM collection every 2 months have more symptoms following BM donation. Approaches should be developed by registries and low volume centers to address this issue. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/p39d-3z18Test; https://cdr.lib.unc.edu/downloads/ff365c22n?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/ff365c22nTest |
| DOI: | 10.17615/p39d-3z18 |
| الإتاحة: | https://doi.org/10.17615/p39d-3z18Test https://cdr.lib.unc.edu/downloads/ff365c22n?file=thumbnailTest https://cdr.lib.unc.edu/downloads/ff365c22nTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.741B711 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/p39d-3z18 |
|---|