دورية أكاديمية
Significance of hyperprolactinemia for cytomorphologic features of breast secretions
| العنوان: | Significance of hyperprolactinemia for cytomorphologic features of breast secretions |
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| المؤلفون: | Radojković Danijela, Antić Slobodan, Pešić Milica, Radojković Milan, Bašić Dijana, Rađenović-Petković Tatjana, Radenković Saša, Ilić Ivan |
| المصدر: | Vojnosanitetski Pregled, Vol 67, Iss 1, Pp 42-47 (2010) |
| بيانات النشر: | Military Health Department, Ministry of Defance, Serbia |
| سنة النشر: | 2010 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | hyperprolactinemia, breast, cytology, exudates and transudates, nipples, Medicine (General), R5-920 |
| الوصف: | Background/Aim. Nipple discharge syndrome is a clinical entity capable of presenting various disorders such is mammary infection (nonpuerperal and puerperal mastitis), intraductal papillomas, fibrodenoma, breast cancer and hyperprolactinemia syndrome. The aim of the study was to determine differencies in cytological features of mammary secretion in patients with hyperprolactinemia and those with normal serum prolactin levels and to define the role of growth hormone, follicle-stimulating hormone, luteinizing hormone and thyroid-stimulating hormone in creating cellular profile of breast secretion. Methods. The study included 50 patients with nipple discharge syndrome. The patients were devided into the clinical group (27 patients with hyperprolactinemia and nipple discharge) and the control group I (23 patients with normal serum prolactin and nipple discharge). The control group II included the patients of the clinical group achiving normalised serum prolactin levels after the treatment of hyperprolactinemia. Serum prolactin, follicle-stimulating hormone and luteinizing hormone levels were assessed by RIA using commercial kits IRMA hPRL, hLH and hFSH, (INEP, Zemun, Serbia) while serum growth hormone and thyroid-stimulating hormone levels were assessed by RIA using commercial kits LKB-wallac. Cytologic evaluation of samples, taken from all the patients with mammary secretion, was done using standard techniques of staining Haemathoxilin-eozine and May- Grünwald/Giemsa. Results. Our results showed a significantly higher presence of lipid and protein material in clinical group, in comparison with the control group I (p < 0.01). Also, our data demonstrated significantly higher number of ductal epithelial cells (p < 0.05) and ductal histiocities (p < 0.001) in the clinical group, compared with the control group I. Macrophagies frequency was proportionally higher in clinical group (44.44%) compared the control group I (17.39%). Erythrocites were significantly lower in the clinical group (p < 0.001) than in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English Serbian |
| تدمد: | 0042-8450 |
| العلاقة: | https://doaj.org/toc/0042-8450Test; https://doaj.org/article/bba045e6b4b849aab3e7008f4921f0bdTest |
| DOI: | 10.2298/VSP1001042R |
| الإتاحة: | https://doi.org/10.2298/VSP1001042RTest https://doaj.org/article/bba045e6b4b849aab3e7008f4921f0bdTest |
| رقم الانضمام: | edsbas.28133C6B |
| قاعدة البيانات: | BASE |
| تدمد: | 00428450 |
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| DOI: | 10.2298/VSP1001042R |